FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091911524> ?p ?o ?g. }

• W3091911524 abstract "Abstract The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria. We report a strong signature of miRNA expression differentiation associated with P. falciparum infection (127 out of 320 miRNAs, B-H FDR 5%) and parasitemia (72 miRNAs, B-H FDR 5%). Integrative miRNA-mRNA analysis implicates several infection-responsive miRNAs (e.g., miR-16-5p, miR-15a-5p and miR-181c-5p) promoting lymphocyte cell death. miRNA cis -eQTL analysis using whole-genome sequencing data identified 1,376 genetic variants associated with the expression of 34 miRNAs (B-H FDR 5%). We report a protective effect of rs114136945 minor allele on parasitemia mediated through miR-598-3p expression. These results highlight the impact of post-transcriptional regulation, immune cell death processes and host genetic regulatory control in malaria." @default.
• W3091911524 created "2020-10-15" @default.
• W3091911524 creator A5010229562 @default.
• W3091911524 creator A5013139296 @default.
• W3091911524 creator A5015600464 @default.
• W3091911524 creator A5018442841 @default.
• W3091911524 creator A5040533373 @default.
• W3091911524 creator A5049881877 @default.
• W3091911524 creator A5051790261 @default.
• W3091911524 creator A5051899125 @default.
• W3091911524 creator A5057254767 @default.
• W3091911524 creator A5059437494 @default.
• W3091911524 creator A5062462284 @default.
• W3091911524 creator A5077242565 @default.
• W3091911524 creator A5077466521 @default.
• W3091911524 creator A5087161283 @default.
• W3091911524 creator A5090418029 @default.
• W3091911524 creator A5016019425 @default.
• W3091911524 date "2020-10-09" @default.
• W3091911524 modified "2023-10-16" @default.
• W3091911524 title "Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria" @default.
• W3091911524 cites W1018606383 @default.
• W3091911524 cites W1856196215 @default.
• W3091911524 cites W1908991493 @default.
• W3091911524 cites W1936515813 @default.
• W3091911524 cites W1960200814 @default.
• W3091911524 cites W1965152588 @default.
• W3091911524 cites W1967206395 @default.
• W3091911524 cites W1973200069 @default.
• W3091911524 cites W1979382630 @default.
• W3091911524 cites W1985563073 @default.
• W3091911524 cites W2007220581 @default.
• W3091911524 cites W2013106911 @default.
• W3091911524 cites W2013556987 @default.
• W3091911524 cites W2026014108 @default.
• W3091911524 cites W2028994878 @default.
• W3091911524 cites W2029021004 @default.
• W3091911524 cites W2033370790 @default.
• W3091911524 cites W2042004955 @default.
• W3091911524 cites W2053733754 @default.
• W3091911524 cites W2054672240 @default.
• W3091911524 cites W2070407983 @default.
• W3091911524 cites W2073737981 @default.
• W3091911524 cites W2109543073 @default.
• W3091911524 cites W2134541285 @default.
• W3091911524 cites W2136369890 @default.
• W3091911524 cites W2139212041 @default.
• W3091911524 cites W2139564620 @default.
• W3091911524 cites W2144662025 @default.
• W3091911524 cites W2147997830 @default.
• W3091911524 cites W2151754909 @default.
• W3091911524 cites W2158040122 @default.
• W3091911524 cites W2164675862 @default.
• W3091911524 cites W2164734679 @default.
• W3091911524 cites W2343186061 @default.
• W3091911524 cites W2530854665 @default.
• W3091911524 cites W2600132724 @default.
• W3091911524 cites W2740697623 @default.
• W3091911524 cites W2743511563 @default.
• W3091911524 cites W2761537341 @default.
• W3091911524 cites W2805356391 @default.
• W3091911524 cites W2808421411 @default.
• W3091911524 cites W2809352278 @default.
• W3091911524 cites W2884531914 @default.
• W3091911524 cites W2913499306 @default.
• W3091911524 cites W2952421891 @default.
• W3091911524 cites W2962751012 @default.
• W3091911524 cites W2969979149 @default.
• W3091911524 cites W2980845278 @default.
• W3091911524 cites W2991922292 @default.
• W3091911524 cites W3006366423 @default.
• W3091911524 cites W4211090760 @default.
• W3091911524 doi "https://doi.org/10.1038/s41467-020-18915-6" @default.
• W3091911524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7547729" @default.
• W3091911524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33037226" @default.
• W3091911524 hasPublicationYear "2020" @default.
• W3091911524 type Work @default.
• W3091911524 sameAs 3091911524 @default.
• W3091911524 citedByCount "8" @default.
• W3091911524 countsByYear W30919115242021 @default.
• W3091911524 countsByYear W30919115242023 @default.
• W3091911524 crossrefType "journal-article" @default.
• W3091911524 hasAuthorship W3091911524A5010229562 @default.
• W3091911524 hasAuthorship W3091911524A5013139296 @default.
• W3091911524 hasAuthorship W3091911524A5015600464 @default.
• W3091911524 hasAuthorship W3091911524A5016019425 @default.
• W3091911524 hasAuthorship W3091911524A5018442841 @default.
• W3091911524 hasAuthorship W3091911524A5040533373 @default.
• W3091911524 hasAuthorship W3091911524A5049881877 @default.
• W3091911524 hasAuthorship W3091911524A5051790261 @default.
• W3091911524 hasAuthorship W3091911524A5051899125 @default.
• W3091911524 hasAuthorship W3091911524A5057254767 @default.
• W3091911524 hasAuthorship W3091911524A5059437494 @default.
• W3091911524 hasAuthorship W3091911524A5062462284 @default.
• W3091911524 hasAuthorship W3091911524A5077242565 @default.
• W3091911524 hasAuthorship W3091911524A5077466521 @default.
• W3091911524 hasAuthorship W3091911524A5087161283 @default.
• W3091911524 hasAuthorship W3091911524A5090418029 @default.
• W3091911524 hasBestOaLocation W30919115241 @default.
• W3091911524 hasConcept C104317684 @default.

• next