Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091949062> ?p ?o ?g. }
- W3091949062 abstract "We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymicrobial sepsis and reduces hyperimmune stimulation (cytokine storm) induced by an overwhelming bacterial infection. Protection is due in part to enhanced bacterial phagocytosis in vivo, changes in lipid metabolism and decreased activation of NF-κB and the NLRP3 inflammasome. The inactivation of BTK leads to reduced innate immune cell recruitment and a phenotypic switch from M1 to M2 macrophages, aiding in the resolution of sepsis. We have also found that BTK expression in humans is increased in the blood of septic non-survivors, while lower expression is associated with survival from sepsis. Importantly no further reduction in organ damage, cytokine production, or changes in plasma metabolites is seen in Xid mice treated with the BTK inhibitor ibrutinib, demonstrating that the protective effects of BTK inhibitors in polymicrobial sepsis are mediated solely by inhibition of BTK and not by off-target effects of this class of drugs." @default.
- W3091949062 created "2020-10-15" @default.
- W3091949062 creator A5005920096 @default.
- W3091949062 creator A5011220231 @default.
- W3091949062 creator A5013883470 @default.
- W3091949062 creator A5023560846 @default.
- W3091949062 creator A5042545371 @default.
- W3091949062 creator A5043853359 @default.
- W3091949062 creator A5053617285 @default.
- W3091949062 creator A5055427369 @default.
- W3091949062 creator A5064842155 @default.
- W3091949062 creator A5067731460 @default.
- W3091949062 creator A5077841299 @default.
- W3091949062 creator A5080589972 @default.
- W3091949062 creator A5085621137 @default.
- W3091949062 date "2020-10-07" @default.
- W3091949062 modified "2023-10-13" @default.
- W3091949062 title "X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure" @default.
- W3091949062 cites W1518095394 @default.
- W3091949062 cites W1858395774 @default.
- W3091949062 cites W1881600351 @default.
- W3091949062 cites W1951228116 @default.
- W3091949062 cites W1966408108 @default.
- W3091949062 cites W1974337260 @default.
- W3091949062 cites W1980424395 @default.
- W3091949062 cites W1982185661 @default.
- W3091949062 cites W1986979099 @default.
- W3091949062 cites W1991209345 @default.
- W3091949062 cites W1992617022 @default.
- W3091949062 cites W199740677 @default.
- W3091949062 cites W2017350973 @default.
- W3091949062 cites W2019294202 @default.
- W3091949062 cites W2025579396 @default.
- W3091949062 cites W2040478956 @default.
- W3091949062 cites W2049017883 @default.
- W3091949062 cites W2054526083 @default.
- W3091949062 cites W2091410303 @default.
- W3091949062 cites W2095027014 @default.
- W3091949062 cites W2100034730 @default.
- W3091949062 cites W2100128950 @default.
- W3091949062 cites W2110065044 @default.
- W3091949062 cites W2116965731 @default.
- W3091949062 cites W2126635383 @default.
- W3091949062 cites W2149654934 @default.
- W3091949062 cites W2155712529 @default.
- W3091949062 cites W2163167085 @default.
- W3091949062 cites W2165297972 @default.
- W3091949062 cites W2169702024 @default.
- W3091949062 cites W2257342069 @default.
- W3091949062 cites W2280404143 @default.
- W3091949062 cites W2346914972 @default.
- W3091949062 cites W2398028989 @default.
- W3091949062 cites W2419595939 @default.
- W3091949062 cites W2546694530 @default.
- W3091949062 cites W2588583898 @default.
- W3091949062 cites W2593676156 @default.
- W3091949062 cites W2747882116 @default.
- W3091949062 cites W2757336747 @default.
- W3091949062 cites W2766697888 @default.
- W3091949062 cites W2774438734 @default.
- W3091949062 cites W2790484425 @default.
- W3091949062 cites W2791299132 @default.
- W3091949062 cites W2793620881 @default.
- W3091949062 cites W2794403789 @default.
- W3091949062 cites W2807906301 @default.
- W3091949062 cites W2823725159 @default.
- W3091949062 cites W2884966596 @default.
- W3091949062 cites W2889367571 @default.
- W3091949062 cites W2889597388 @default.
- W3091949062 cites W2895086405 @default.
- W3091949062 cites W2896299871 @default.
- W3091949062 cites W2904886130 @default.
- W3091949062 cites W2912634793 @default.
- W3091949062 cites W2920712688 @default.
- W3091949062 cites W2921729329 @default.
- W3091949062 cites W2942444134 @default.
- W3091949062 cites W2969789732 @default.
- W3091949062 cites W2988152617 @default.
- W3091949062 cites W2994957013 @default.
- W3091949062 cites W2997708552 @default.
- W3091949062 cites W2998853022 @default.
- W3091949062 cites W3007633606 @default.
- W3091949062 cites W3010843852 @default.
- W3091949062 cites W3011117765 @default.
- W3091949062 cites W3012116029 @default.
- W3091949062 cites W3013864124 @default.
- W3091949062 cites W3016555942 @default.
- W3091949062 cites W3034129242 @default.
- W3091949062 cites W3039185763 @default.
- W3091949062 cites W602304908 @default.
- W3091949062 doi "https://doi.org/10.3389/fimmu.2020.581758" @default.
- W3091949062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7580254" @default.
- W3091949062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33162995" @default.
- W3091949062 hasPublicationYear "2020" @default.
- W3091949062 type Work @default.
- W3091949062 sameAs 3091949062 @default.
- W3091949062 citedByCount "16" @default.
- W3091949062 countsByYear W30919490622021 @default.
- W3091949062 countsByYear W30919490622022 @default.
- W3091949062 countsByYear W30919490622023 @default.