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• W3091961227 abstract "Pathological coagulation, a disorder of blood clotting regulation, induces a number of cardiovascular diseases. A safe and efficient system for the delivery of anticoagulants to mimic the physiological negative feedback mechanism by responding to the coagulation signal changes holds the promise and potential for anticoagulant therapy. Here, we exploit a closed-loop controlled release strategy for the delivery of recombinant hirudin, an anticoagulant agent that uses a self-regulated nanoscale polymeric gel. The cross-linked nanogel network increases the stability and bioavailability of hirudin and reduces its clearance in vivo. Equipped with the clot-targeted ligand, the engineered nanogels promote the accumulation of hirudin in the fibrous clots and adaptively release the encapsulated hirudin upon the thrombin variation during the pathological proceeding of thrombus for potentiating anticoagulant activity and alleviating adverse effects. We show that this formulation efficiently prevents and inhibits the clot formation on the mouse models of pulmonary embolism and thrombosis." @default.
• W3091961227 created "2020-10-15" @default.
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• W3091961227 date "2020-10-09" @default.
• W3091961227 modified "2023-10-13" @default.
• W3091961227 title "Self-regulated hirudin delivery for anticoagulant therapy" @default.
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• W3091961227 doi "https://doi.org/10.1126/sciadv.abc0382" @default.
• W3091961227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7546707" @default.
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• W3091961227 hasPublicationYear "2020" @default.
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