Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091991300> ?p ?o ?g. }
- W3091991300 endingPage "155321" @default.
- W3091991300 startingPage "155321" @default.
- W3091991300 abstract "Infection with the same species of Leishmania (L)donovani causes different manifestations including visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL), indicating that the host-related immunological parameters perform a decisive role in the pathogenesis of diseases. As PKDL is a reservoir of the parasite, a better understanding of the host immune responses is necessary to restrict the L. donovani transmission. The proper local production of Th1 cell-related cytokines (including IFN-γ, TNF-α and IL-12), Th17 cell-derived cytokines (such as IL-17A, IL-17F and IL-22), and CD8+ cytotoxic T lymphocyte (CTL)-derived IFN-γ are protective against PKDL. However, dominant production of regulatory CD4+ T cell-derived cytokines (such as IL-10 and TGF-β), Th2 cell-derived cytokines (such as IL-4/IL-13), M2 macrophage-derived cytokines (such as IL-4 and IL-10), keratinocyte-derived IL-10, regulatory CD8+ T cell-derived IL-10, and dendritic cell-derived IL-10, IL-27 and IL-21 can contribute to the parasite persistence and PKDL development. Understanding of the T cell-related cytokine network within PKDL lesions gives rise to novel insights concerning the role of each cytokine in the protection or susceptibility to disease. Manipulation of the cytokine network can be considered as an interesting immunotherapeutic strategy for the treatment of L. donovani-mediated PKDL." @default.
- W3091991300 created "2020-10-15" @default.
- W3091991300 creator A5009380259 @default.
- W3091991300 creator A5011869628 @default.
- W3091991300 creator A5039968589 @default.
- W3091991300 creator A5071007863 @default.
- W3091991300 creator A5085113824 @default.
- W3091991300 creator A5090865617 @default.
- W3091991300 date "2021-11-01" @default.
- W3091991300 modified "2023-10-02" @default.
- W3091991300 title "The importance of T cell-derived cytokines in post-kala-azar dermal leishmaniasis" @default.
- W3091991300 cites W1514702282 @default.
- W3091991300 cites W1551954193 @default.
- W3091991300 cites W1572040302 @default.
- W3091991300 cites W1697150691 @default.
- W3091991300 cites W1825050981 @default.
- W3091991300 cites W1909009992 @default.
- W3091991300 cites W1939188567 @default.
- W3091991300 cites W1944631314 @default.
- W3091991300 cites W1964133657 @default.
- W3091991300 cites W1967327441 @default.
- W3091991300 cites W1967758891 @default.
- W3091991300 cites W1967828232 @default.
- W3091991300 cites W1975159342 @default.
- W3091991300 cites W1976469493 @default.
- W3091991300 cites W1992432991 @default.
- W3091991300 cites W2002204067 @default.
- W3091991300 cites W2003948064 @default.
- W3091991300 cites W2004426423 @default.
- W3091991300 cites W2006954455 @default.
- W3091991300 cites W2010516618 @default.
- W3091991300 cites W2017368813 @default.
- W3091991300 cites W2018141885 @default.
- W3091991300 cites W2029057112 @default.
- W3091991300 cites W2030844202 @default.
- W3091991300 cites W2038204393 @default.
- W3091991300 cites W2040479272 @default.
- W3091991300 cites W2043078175 @default.
- W3091991300 cites W2043796257 @default.
- W3091991300 cites W2044585217 @default.
- W3091991300 cites W2047634773 @default.
- W3091991300 cites W2054472394 @default.
- W3091991300 cites W2054943138 @default.
- W3091991300 cites W2056956379 @default.
- W3091991300 cites W2057282948 @default.
- W3091991300 cites W2061933750 @default.
- W3091991300 cites W2064765218 @default.
- W3091991300 cites W2066732010 @default.
- W3091991300 cites W2067091770 @default.
- W3091991300 cites W2070721887 @default.
- W3091991300 cites W2073537502 @default.
- W3091991300 cites W2074759202 @default.
- W3091991300 cites W2074895355 @default.
- W3091991300 cites W2078555782 @default.
- W3091991300 cites W2086258935 @default.
- W3091991300 cites W2094091054 @default.
- W3091991300 cites W2103398514 @default.
- W3091991300 cites W2103873848 @default.
- W3091991300 cites W2109849519 @default.
- W3091991300 cites W2111819389 @default.
- W3091991300 cites W2119398725 @default.
- W3091991300 cites W2121932349 @default.
- W3091991300 cites W2123497591 @default.
- W3091991300 cites W2124369626 @default.
- W3091991300 cites W2125274566 @default.
- W3091991300 cites W2133675087 @default.
- W3091991300 cites W2134264211 @default.
- W3091991300 cites W2141841595 @default.
- W3091991300 cites W2142821081 @default.
- W3091991300 cites W2144756920 @default.
- W3091991300 cites W2145152098 @default.
- W3091991300 cites W2155792295 @default.
- W3091991300 cites W2161367264 @default.
- W3091991300 cites W2171620267 @default.
- W3091991300 cites W2216402574 @default.
- W3091991300 cites W2252704427 @default.
- W3091991300 cites W2296730015 @default.
- W3091991300 cites W2339970694 @default.
- W3091991300 cites W2343281078 @default.
- W3091991300 cites W2428092023 @default.
- W3091991300 cites W2464427427 @default.
- W3091991300 cites W2465974855 @default.
- W3091991300 cites W2504516532 @default.
- W3091991300 cites W2514075597 @default.
- W3091991300 cites W2560758606 @default.
- W3091991300 cites W2569512551 @default.
- W3091991300 cites W2626102211 @default.
- W3091991300 cites W2741412374 @default.
- W3091991300 cites W2777873599 @default.
- W3091991300 cites W2782685575 @default.
- W3091991300 cites W2785920261 @default.
- W3091991300 cites W2793360611 @default.
- W3091991300 cites W2793763304 @default.
- W3091991300 cites W2803378635 @default.
- W3091991300 cites W2909283197 @default.
- W3091991300 cites W2913468892 @default.
- W3091991300 cites W2914652563 @default.
- W3091991300 cites W2925572925 @default.