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- W3091994528 endingPage "100730" @default.
- W3091994528 startingPage "100730" @default.
- W3091994528 abstract "New treatment options of acute myeloid leukemia (AML) are rapidly emerging. Pre-clinical models such as ex vivo cultures are extensively used towards the development of novel drugs and to study synergistic drug combinations, as well as to discover biomarkers for both drug response and anti-cancer drug resistance. Although these approaches empower efficient investigation of multiple drugs in a multitude of primary AML samples, their translational value and reproducibility are hampered by the lack of standardized methodologies and by culture system-specific behavior of AML cells and chemotherapeutic drugs. Moreover, distinct research questions require specific methods which rely on specific technical knowledge and skills. To address these aspects, we herein review commonly used culture techniques in light of diverse research questions. In addition, culture-dependent effects on drug resistance towards commonly used drugs in the treatment of AML are summarized including several pitfalls that may arise because of culture technique artifacts. The primary aim of the current review is to provide practical guidelines for ex vivo primary AML culture experimental design." @default.
- W3091994528 created "2020-10-15" @default.
- W3091994528 creator A5004736861 @default.
- W3091994528 creator A5020528788 @default.
- W3091994528 creator A5023902781 @default.
- W3091994528 creator A5070729528 @default.
- W3091994528 date "2020-12-01" @default.
- W3091994528 modified "2023-10-04" @default.
- W3091994528 title "Ex vivo cultures and drug testing of primary acute myeloid leukemia samples: Current techniques and implications for experimental design and outcome" @default.
- W3091994528 cites W1507261415 @default.
- W3091994528 cites W1520176984 @default.
- W3091994528 cites W1851763797 @default.
- W3091994528 cites W1857797520 @default.
- W3091994528 cites W1928092987 @default.
- W3091994528 cites W1965237065 @default.
- W3091994528 cites W1966101727 @default.
- W3091994528 cites W1968611056 @default.
- W3091994528 cites W1968779484 @default.
- W3091994528 cites W1975798779 @default.
- W3091994528 cites W1976003274 @default.
- W3091994528 cites W1976675965 @default.
- W3091994528 cites W1979129905 @default.
- W3091994528 cites W1981811959 @default.
- W3091994528 cites W1983420428 @default.
- W3091994528 cites W1983636872 @default.
- W3091994528 cites W1987777080 @default.
- W3091994528 cites W1988843247 @default.
- W3091994528 cites W2002783575 @default.
- W3091994528 cites W2006161214 @default.
- W3091994528 cites W2009993055 @default.
- W3091994528 cites W2013679409 @default.
- W3091994528 cites W2018794251 @default.
- W3091994528 cites W2020671440 @default.
- W3091994528 cites W2021031299 @default.
- W3091994528 cites W2021486585 @default.
- W3091994528 cites W2021550972 @default.
- W3091994528 cites W2021949600 @default.
- W3091994528 cites W2022894865 @default.
- W3091994528 cites W2024855986 @default.
- W3091994528 cites W2024863226 @default.
- W3091994528 cites W2030579061 @default.
- W3091994528 cites W2030873172 @default.
- W3091994528 cites W2032622818 @default.
- W3091994528 cites W2035614371 @default.
- W3091994528 cites W2039937583 @default.
- W3091994528 cites W2040568539 @default.
- W3091994528 cites W2041745779 @default.
- W3091994528 cites W2041997066 @default.
- W3091994528 cites W2042728323 @default.
- W3091994528 cites W2043113279 @default.
- W3091994528 cites W2043402587 @default.
- W3091994528 cites W2053094576 @default.
- W3091994528 cites W2053737668 @default.
- W3091994528 cites W2065831993 @default.
- W3091994528 cites W2065954286 @default.
- W3091994528 cites W2074156234 @default.
- W3091994528 cites W2078616374 @default.
- W3091994528 cites W2081409454 @default.
- W3091994528 cites W2081840535 @default.
- W3091994528 cites W2086402500 @default.
- W3091994528 cites W2087734794 @default.
- W3091994528 cites W2089144005 @default.
- W3091994528 cites W2089617043 @default.
- W3091994528 cites W2090190145 @default.
- W3091994528 cites W2091552147 @default.
- W3091994528 cites W2092436347 @default.
- W3091994528 cites W2102461774 @default.
- W3091994528 cites W2105434446 @default.
- W3091994528 cites W2107994994 @default.
- W3091994528 cites W2113011422 @default.
- W3091994528 cites W2116386021 @default.
- W3091994528 cites W2128828794 @default.
- W3091994528 cites W2134898498 @default.
- W3091994528 cites W2141906186 @default.
- W3091994528 cites W2143000352 @default.
- W3091994528 cites W2147139497 @default.
- W3091994528 cites W2161226422 @default.
- W3091994528 cites W2162830250 @default.
- W3091994528 cites W2163219293 @default.
- W3091994528 cites W2164310993 @default.
- W3091994528 cites W2167303139 @default.
- W3091994528 cites W2168142681 @default.
- W3091994528 cites W2168172745 @default.
- W3091994528 cites W2173261030 @default.
- W3091994528 cites W2174894224 @default.
- W3091994528 cites W2274550965 @default.
- W3091994528 cites W2321953223 @default.
- W3091994528 cites W2331628193 @default.
- W3091994528 cites W2334818382 @default.
- W3091994528 cites W2336267737 @default.
- W3091994528 cites W2339581795 @default.
- W3091994528 cites W2341769195 @default.
- W3091994528 cites W2342311422 @default.
- W3091994528 cites W2343982821 @default.
- W3091994528 cites W2470668351 @default.
- W3091994528 cites W2472104278 @default.
- W3091994528 cites W2486348902 @default.
- W3091994528 cites W2502718344 @default.