Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092007298> ?p ?o ?g. }
- W3092007298 abstract "Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients." @default.
- W3092007298 created "2020-10-15" @default.
- W3092007298 creator A5001752307 @default.
- W3092007298 creator A5048523154 @default.
- W3092007298 creator A5082381499 @default.
- W3092007298 creator A5091065467 @default.
- W3092007298 date "2020-10-09" @default.
- W3092007298 modified "2023-10-10" @default.
- W3092007298 title "Concepts of extracellular matrix remodelling in tumour progression and metastasis" @default.
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