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- W3092017180 startingPage "107041" @default.
- W3092017180 abstract "• The number of MDSCs is higher in both blood and tumor of CRC cases. • Germline mutations are reported to be the major cause of CRC development. • Among various treatment modalities, ICIs therapy have shown best response. • Epigenetic plays a role in the etiology of sporadic CRC. • In the majority of CRC patients, combination therapy is necessary. • The idea of combining epigenetic therapy such as histone methyl transferase inhibitors and immunotherapy is a promising approach. Colorectal cancer (CRC) is considered as the second most common cancer worldwide. For the past few years, the role of immunotherapy has been extensively studied and it has been demonstrated that its related approaches, such as programmed death-1 (PD-1) inhibitors, are promising. In addition to identifying molecular characteristics of tumor cells, recent studies are mainly focused on the profiling of tumor microenvironment. Dissecting immune status of a tumor is interesting, since development of a tumor is associated with deficiencies relate to immune defense, immune surveillance and immune hemostasis. In this review, we discuss main obstacles of immunotherapy including immunosuppressive niche and low immunogenicity of CRC as well as reviewing current achievements in immunotherapy." @default.
- W3092017180 created "2020-10-15" @default.
- W3092017180 creator A5009093556 @default.
- W3092017180 creator A5034690828 @default.
- W3092017180 creator A5037880358 @default.
- W3092017180 creator A5065058975 @default.
- W3092017180 creator A5069590869 @default.
- W3092017180 date "2020-12-01" @default.
- W3092017180 modified "2023-10-18" @default.
- W3092017180 title "An update on colorectal cancer microenvironment, epigenetic and immunotherapy" @default.
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