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- W3092019292 abstract "High lipoprotein(a) [Lp(a)] levels are associated with the development of atherosclerotic cardiovascular disease (ASCVD) and with calcific aortic valve stenosis (CAVS) both observationally and causally from human genetic studies. The mechanisms are not well characterized but likely involve its role as a carrier of oxidized phospholipids (OxPLs), which are known to be increased in pro-inflammatory states, to induce pro-inflammatory changes in monocytes leading to plaque instability, and to impair vascular endothelial cell function, a driver of acute and recurrent ischemic events. In addition, Lp(a) itself has prothrombotic activity. Current lipid-lowering strategies do not sufficiently lower Lp(a) serum levels. Lp(a)-specific-lowering drugs, targeting apolipoprotein(a) synthesis, lower Lp(a) by up to 90% and are being evaluated in ongoing clinical outcome trials. This review summarizes the current knowledge on the associations of Lp(a) with ASCVD and CAVS, the current role of Lp(a) assessment in the clinical setting, and emerging Lp(a)-specific-lowering therapies." @default.
- W3092019292 created "2020-10-15" @default.
- W3092019292 creator A5042651954 @default.
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- W3092019292 date "2020-11-01" @default.
- W3092019292 modified "2023-10-01" @default.
- W3092019292 title "The role of Lipoprotein(a) in cardiovascular disease: Current concepts and future perspectives" @default.
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- W3092019292 doi "https://doi.org/10.1016/j.hjc.2020.09.016" @default.
- W3092019292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33039574" @default.
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