Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092040529> ?p ?o ?g. }
- W3092040529 abstract "Abstract Adenosine Deaminases that act on RNA (ADARs) are enzymes that catalyze adenosine to inosine conversion in dsRNA, a common form of RNA editing. Mutations in the human ADAR1 gene are known to cause disease and recent studies have identified ADAR1 as a potential therapeutic target for a subset of cancers. However, efforts to define the mechanistic effects for disease associated ADAR1 mutations and the rational design of ADAR1 inhibitors are limited by a lack of structural information. Here, we describe the combination of high throughput mutagenesis screening studies, biochemical characterization and Rosetta-based structure modeling to identify unique features of ADAR1. Importantly, these studies reveal a previously unknown zinc-binding site on the surface of the ADAR1 deaminase domain which is important for ADAR1 editing activity. Furthermore, we present structural models that explain known properties of this enzyme and make predictions about the role of specific residues in a surface loop unique to ADAR1." @default.
- W3092040529 created "2020-10-15" @default.
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- W3092040529 date "2020-10-12" @default.
- W3092040529 modified "2023-10-17" @default.
- W3092040529 title "High-throughput mutagenesis reveals unique structural features of human ADAR1" @default.
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- W3092040529 cites W1966405432 @default.
- W3092040529 cites W1968686367 @default.
- W3092040529 cites W1969219020 @default.
- W3092040529 cites W1977170693 @default.
- W3092040529 cites W1978974023 @default.
- W3092040529 cites W1979100273 @default.
- W3092040529 cites W1991344879 @default.
- W3092040529 cites W1996063915 @default.
- W3092040529 cites W2007558709 @default.
- W3092040529 cites W2014118067 @default.
- W3092040529 cites W2017848780 @default.
- W3092040529 cites W2021867336 @default.
- W3092040529 cites W2033901156 @default.
- W3092040529 cites W2038591876 @default.
- W3092040529 cites W2044145005 @default.
- W3092040529 cites W2044183281 @default.
- W3092040529 cites W2050585922 @default.
- W3092040529 cites W2051992432 @default.
- W3092040529 cites W2052498582 @default.
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- W3092040529 doi "https://doi.org/10.1038/s41467-020-18862-2" @default.
- W3092040529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7550611" @default.
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- W3092040529 hasPublicationYear "2020" @default.
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