Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092052361> ?p ?o ?g. }
- W3092052361 endingPage "2718" @default.
- W3092052361 startingPage "2710" @default.
- W3092052361 abstract "Sepsis is associated with ascorbic acid (AA) depletion and critical illness-related corticosteroid insufficiency (CIRCI) in humans.Intravenous infusion of lipopolysaccharide (LPS) would (a) decrease endogneous AA concentrations, (b) induce CIRCI and (c) administration of a combination of AA and hydrocortisone (HC) would have decreased indices of inflammation compared to either drug alone.Thirty-two healthy horses.Randomized placebo-controlled experimental trial. Horses were assigned to 1 of 4 groups (saline, AA and HC, AA only, or HC only). Treatments were administered 1 hour after completion of LPS infusion. Clinical signs, clinicopathological variables, pro-inflammatory cytokine gene expression and production, and plasma AA concentrations were assessed at various time points. Serum cortisol concentrations and ACTH stimulation tests were used to detect CIRCI.There was no effect of drug on clinical signs or pro-inflammatory cytokine gene expression or production compared to controls at any time point. Administration of AA was associated with higher blood neutrophil counts 6 hours after LPS infusion (11.01 ± 1.02 K/μl) compared to other groups (8.99 ± 0.94 K/μL; P < .009). Adminstration of HC was associated with higher blood neutrophil counts 12 hours after LPS infusion (10.40 ± 0.75 K/μl) compared to other groups (6.88 ± 0.68 K/μl; P < .001). Serum cortisol increased from 5.11 ± 1.48 μg/dL before LPS administration to 9.59 ± 1.83 μg/dL 1 h after completion of LPS infusion (T1) without an effect of treatment (P = 0.59).Ascorbic acid and HC appeared to protect against LPS-induced neutrophil depletion and could be considered as adjunctive therapy in horses with endotoxemia." @default.
- W3092052361 created "2020-10-15" @default.
- W3092052361 creator A5024885577 @default.
- W3092052361 creator A5041028053 @default.
- W3092052361 creator A5059490228 @default.
- W3092052361 creator A5068438813 @default.
- W3092052361 creator A5072597579 @default.
- W3092052361 creator A5090675946 @default.
- W3092052361 date "2020-10-07" @default.
- W3092052361 modified "2023-09-24" @default.
- W3092052361 title "Effects of administration of ascorbic acid and low‐dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses" @default.
- W3092052361 cites W120513920 @default.
- W3092052361 cites W162086469 @default.
- W3092052361 cites W1753683453 @default.
- W3092052361 cites W1896508015 @default.
- W3092052361 cites W1897702161 @default.
- W3092052361 cites W1902060129 @default.
- W3092052361 cites W19204887 @default.
- W3092052361 cites W1945898151 @default.
- W3092052361 cites W1967897225 @default.
- W3092052361 cites W1972038765 @default.
- W3092052361 cites W1978510581 @default.
- W3092052361 cites W1979059006 @default.
- W3092052361 cites W1979145667 @default.
- W3092052361 cites W1979414063 @default.
- W3092052361 cites W1983730775 @default.
- W3092052361 cites W1984372443 @default.
- W3092052361 cites W1985245293 @default.
- W3092052361 cites W1988663001 @default.
- W3092052361 cites W1988873331 @default.
- W3092052361 cites W1990129585 @default.
- W3092052361 cites W1990487788 @default.
- W3092052361 cites W2003238231 @default.
- W3092052361 cites W2004072697 @default.
- W3092052361 cites W2004213488 @default.
- W3092052361 cites W2004971894 @default.
- W3092052361 cites W2005968970 @default.
- W3092052361 cites W2008519945 @default.
- W3092052361 cites W2015542500 @default.
- W3092052361 cites W2024566453 @default.
- W3092052361 cites W2030896227 @default.
- W3092052361 cites W2050080161 @default.
- W3092052361 cites W2058867257 @default.
- W3092052361 cites W2061427774 @default.
- W3092052361 cites W2062841259 @default.
- W3092052361 cites W2065166683 @default.
- W3092052361 cites W2065691453 @default.
- W3092052361 cites W2066186453 @default.
- W3092052361 cites W2067931090 @default.
- W3092052361 cites W2068361753 @default.
- W3092052361 cites W2073134798 @default.
- W3092052361 cites W2073274524 @default.
- W3092052361 cites W2074028698 @default.
- W3092052361 cites W2076579607 @default.
- W3092052361 cites W2077089354 @default.
- W3092052361 cites W2078592237 @default.
- W3092052361 cites W2082399462 @default.
- W3092052361 cites W2082698454 @default.
- W3092052361 cites W2086215320 @default.
- W3092052361 cites W2087301662 @default.
- W3092052361 cites W2087586869 @default.
- W3092052361 cites W2093371231 @default.
- W3092052361 cites W2093546444 @default.
- W3092052361 cites W2094924596 @default.
- W3092052361 cites W2107277218 @default.
- W3092052361 cites W2112516644 @default.
- W3092052361 cites W2112818206 @default.
- W3092052361 cites W2120222399 @default.
- W3092052361 cites W2142538185 @default.
- W3092052361 cites W2151987671 @default.
- W3092052361 cites W2156576576 @default.
- W3092052361 cites W2159099334 @default.
- W3092052361 cites W2173612202 @default.
- W3092052361 cites W2185548361 @default.
- W3092052361 cites W2278136046 @default.
- W3092052361 cites W2281482658 @default.
- W3092052361 cites W2314267398 @default.
- W3092052361 cites W2346427195 @default.
- W3092052361 cites W2409379357 @default.
- W3092052361 cites W2416906832 @default.
- W3092052361 cites W2425782129 @default.
- W3092052361 cites W2466495198 @default.
- W3092052361 cites W2528956578 @default.
- W3092052361 cites W2551841028 @default.
- W3092052361 cites W2560240742 @default.
- W3092052361 cites W2563595710 @default.
- W3092052361 cites W2593772778 @default.
- W3092052361 cites W2695091324 @default.
- W3092052361 cites W2745962991 @default.
- W3092052361 cites W2746717617 @default.
- W3092052361 cites W2757757226 @default.
- W3092052361 cites W2768146862 @default.
- W3092052361 cites W2773432284 @default.
- W3092052361 cites W2790046020 @default.
- W3092052361 cites W2922616773 @default.
- W3092052361 cites W2922896425 @default.
- W3092052361 cites W2973154059 @default.
- W3092052361 cites W2984422529 @default.