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- W3092067959 endingPage "106485" @default.
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- W3092067959 abstract "This study was conducted to explore the influence of genetic variations on responsiveness to valproic acid (VPA) monotherapy among Chinese children with epilepsy. One hundred and forty epileptic children taking VPA as monotherapy were enrolled, and at least one-year follow-up was obtained to assess the therapeutic outcome. Twenty-seven single nucleotide polymorphisms (SNPs) within twelve candidate genes correlated with the metabolic enzymes, transporters and targets of VPA were genotyped. The effects of selected polymorphisms on VPA efficacy were identified by binary logistic regression analysis adjusting for potential confounders. SCN2A rs2304016 (A > G) AG genotype was more common among the VPA-resistant patients in comparison with the VPA-responsive patients (OR = 3.18, 95 % CI = 1.10−9.14, P = 0.032), and in subgroup of focal seizure, lower frequency of VPA resistance was found in epileptic children with SCN1A rs2298771 AG genotype than those with AA genotype (OR = 0.11, 95 % CI = 0.01−0.91, P = 0.040). Our study indicated that SCN2A rs2304016 and SCN1A rs2298771 polymorphisms might be associated with the response to VPA monotherapy in Chinese epileptic children. Further and larger researches are required to validate these results." @default.
- W3092067959 created "2020-10-15" @default.
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- W3092067959 date "2020-12-01" @default.
- W3092067959 modified "2023-10-12" @default.
- W3092067959 title "Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children" @default.
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- W3092067959 doi "https://doi.org/10.1016/j.eplepsyres.2020.106485" @default.
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