Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092075836> ?p ?o ?g. }
- W3092075836 abstract "Background: Currently, a study on the relationship between candidiasis and cancer has been conducted. Until recent years, the opportunistic fungus C. albicans is mainly associated with cancer processes and is able to stimulate carcinogenesis and metastasis. Methods: A number of ionic liquids as potential anticancer and anti-Candida agents have been investigated based on modern theoretical and experimental data about the relationship between oncopathology and candida infection. Results: The analysis of the received experimental results demonstrates that ionic liquid with alkyl chain length of 6 carbon atoms (C6) has not shown anti-Candida activity. The indicators of its cytotoxicity ІС50 (28,617μМ) and MTC (9,050 μМ) against HEP-2 tumor cell line were also very low. Compounds with alkyl chain length C12 have shown high potential of anti-Candida activity and anticancer properties. Conclusion: Based on the obtained results, сompound 4 (C12C1IM-Cl) is proposed for further study as a potential double-acting agent with high anticancer and anti-Candida activities. N-myristoyltransferase is presented and used for docking as a potential molecular target responsible for the dual anti-Сandidа and anticancer activities of studied ionic liquids." @default.
- W3092075836 created "2020-10-15" @default.
- W3092075836 creator A5014769949 @default.
- W3092075836 creator A5017651727 @default.
- W3092075836 creator A5037386566 @default.
- W3092075836 creator A5038778165 @default.
- W3092075836 creator A5061750091 @default.
- W3092075836 creator A5068107626 @default.
- W3092075836 creator A5089571276 @default.
- W3092075836 creator A5090132409 @default.
- W3092075836 date "2020-10-28" @default.
- W3092075836 modified "2023-09-26" @default.
- W3092075836 title "Ionic Liquids with Anti-Candida and Anticancer Dual Activity as Potential N-Myristoyltransferase Inhibitors" @default.
- W3092075836 cites W1978356078 @default.
- W3092075836 cites W1984812705 @default.
- W3092075836 cites W2007227915 @default.
- W3092075836 cites W2020970388 @default.
- W3092075836 cites W2054284233 @default.
- W3092075836 cites W2062710883 @default.
- W3092075836 cites W2073924079 @default.
- W3092075836 cites W2105668062 @default.
- W3092075836 cites W2119452594 @default.
- W3092075836 cites W2136931384 @default.
- W3092075836 cites W2150995105 @default.
- W3092075836 cites W2335205305 @default.
- W3092075836 cites W2338180516 @default.
- W3092075836 cites W2341153623 @default.
- W3092075836 cites W2357343314 @default.
- W3092075836 cites W2409876956 @default.
- W3092075836 cites W2523518651 @default.
- W3092075836 cites W2585056247 @default.
- W3092075836 cites W2589817551 @default.
- W3092075836 cites W2761978082 @default.
- W3092075836 cites W2775845427 @default.
- W3092075836 cites W2786605727 @default.
- W3092075836 cites W2894405761 @default.
- W3092075836 cites W2915056921 @default.
- W3092075836 doi "https://doi.org/10.2174/1573407215666191007120402" @default.
- W3092075836 hasPublicationYear "2020" @default.
- W3092075836 type Work @default.
- W3092075836 sameAs 3092075836 @default.
- W3092075836 citedByCount "0" @default.
- W3092075836 crossrefType "journal-article" @default.
- W3092075836 hasAuthorship W3092075836A5014769949 @default.
- W3092075836 hasAuthorship W3092075836A5017651727 @default.
- W3092075836 hasAuthorship W3092075836A5037386566 @default.
- W3092075836 hasAuthorship W3092075836A5038778165 @default.
- W3092075836 hasAuthorship W3092075836A5061750091 @default.
- W3092075836 hasAuthorship W3092075836A5068107626 @default.
- W3092075836 hasAuthorship W3092075836A5089571276 @default.
- W3092075836 hasAuthorship W3092075836A5090132409 @default.
- W3092075836 hasConcept C109316439 @default.
- W3092075836 hasConcept C145148216 @default.
- W3092075836 hasConcept C154881586 @default.
- W3092075836 hasConcept C159110408 @default.
- W3092075836 hasConcept C161790260 @default.
- W3092075836 hasConcept C178790620 @default.
- W3092075836 hasConcept C185592680 @default.
- W3092075836 hasConcept C202751555 @default.
- W3092075836 hasConcept C2182769 @default.
- W3092075836 hasConcept C21951064 @default.
- W3092075836 hasConcept C2779678110 @default.
- W3092075836 hasConcept C2780263894 @default.
- W3092075836 hasConcept C2780917455 @default.
- W3092075836 hasConcept C41685203 @default.
- W3092075836 hasConcept C55493867 @default.
- W3092075836 hasConcept C59822182 @default.
- W3092075836 hasConcept C71240020 @default.
- W3092075836 hasConcept C71924100 @default.
- W3092075836 hasConcept C86803240 @default.
- W3092075836 hasConcept C89423630 @default.
- W3092075836 hasConceptScore W3092075836C109316439 @default.
- W3092075836 hasConceptScore W3092075836C145148216 @default.
- W3092075836 hasConceptScore W3092075836C154881586 @default.
- W3092075836 hasConceptScore W3092075836C159110408 @default.
- W3092075836 hasConceptScore W3092075836C161790260 @default.
- W3092075836 hasConceptScore W3092075836C178790620 @default.
- W3092075836 hasConceptScore W3092075836C185592680 @default.
- W3092075836 hasConceptScore W3092075836C202751555 @default.
- W3092075836 hasConceptScore W3092075836C2182769 @default.
- W3092075836 hasConceptScore W3092075836C21951064 @default.
- W3092075836 hasConceptScore W3092075836C2779678110 @default.
- W3092075836 hasConceptScore W3092075836C2780263894 @default.
- W3092075836 hasConceptScore W3092075836C2780917455 @default.
- W3092075836 hasConceptScore W3092075836C41685203 @default.
- W3092075836 hasConceptScore W3092075836C55493867 @default.
- W3092075836 hasConceptScore W3092075836C59822182 @default.
- W3092075836 hasConceptScore W3092075836C71240020 @default.
- W3092075836 hasConceptScore W3092075836C71924100 @default.
- W3092075836 hasConceptScore W3092075836C86803240 @default.
- W3092075836 hasConceptScore W3092075836C89423630 @default.
- W3092075836 hasLocation W30920758361 @default.
- W3092075836 hasOpenAccess W3092075836 @default.
- W3092075836 hasPrimaryLocation W30920758361 @default.
- W3092075836 hasRelatedWork W10445348 @default.
- W3092075836 hasRelatedWork W13094661 @default.
- W3092075836 hasRelatedWork W14312536 @default.
- W3092075836 hasRelatedWork W16069148 @default.
- W3092075836 hasRelatedWork W22214763 @default.
- W3092075836 hasRelatedWork W26404334 @default.