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• W3092079205 endingPage "1890" @default.
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• W3092079205 abstract "Measurable residual disease (MRD) refers to neoplastic cells that cannot be detected by standard cytomorphologic analysis. In patients with acute myeloid leukemia (AML), determining the association of MRD with survival may improve prognostication and inform selection of efficient clinical trial end points.To examine the association between MRD status and disease-free survival (DFS) and overall survival (OS) in patients with AML using scientific literature.Clinical studies on AML published between January 1, 2000, and October 1, 2018, were identified via searches of PubMed, Embase, and MEDLINE.Literature search and study screening were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies that assessed DFS or OS by MRD status in patients with AML were included. Reviews, non-English-language articles, and studies reporting only outcomes after hematopoietic cell transplantation or those with insufficient description of MRD information were excluded.Study sample size, median patient age, median follow-up time, MRD detection method, MRD assessment time points, AML subtype, specimen source, and survival outcomes were extracted. Meta-analyses were performed separately for DFS and OS using bayesian hierarchical modeling.Meta-analyses of survival probabilities and hazard ratios (HRs) were conducted for OS and DFS according to MRD status.Eighty-one publications reporting on 11 151 patients were included. The average HR for achieving MRD negativity was 0.36 (95% bayesian credible interval [CrI], 0.33-0.39) for OS and 0.37 (95% CrI, 0.34-0.40) for DFS. The estimated 5-year DFS was 64% for patients without MRD and 25% for those with MRD, and the estimated OS was 68% for patients without MRD and 34% for those with MRD. The association of MRD negativity with DFS and OS was significant for all subgroups, with the exception of MRD assessed by cytogenetics or fluorescent in situ hybridization.The findings of this meta-analysis suggest that achievement of MRD negativity is associated with superior DFS and OS in patients with AML. The value of MRD negativity appears to be consistent across age groups, AML subtypes, time of MRD assessment, specimen source, and MRD detection methods. These results support MRD status as an end point that may allow for accelerated evaluation of novel therapies in AML." @default.
• W3092079205 created "2020-10-15" @default.
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• W3092079205 date "2020-12-01" @default.
• W3092079205 modified "2023-10-11" @default.
• W3092079205 title "Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia" @default.
• W3092079205 cites W1531055081 @default.
• W3092079205 cites W1880892126 @default.
• W3092079205 cites W1910312434 @default.
• W3092079205 cites W1920829940 @default.
• W3092079205 cites W1963777403 @default.
• W3092079205 cites W1969017771 @default.
• W3092079205 cites W1971455987 @default.
• W3092079205 cites W1981462221 @default.
• W3092079205 cites W1982967337 @default.
• W3092079205 cites W1984658294 @default.
• W3092079205 cites W1984938965 @default.
• W3092079205 cites W1986025994 @default.
• W3092079205 cites W1992453745 @default.
• W3092079205 cites W1992656466 @default.
• W3092079205 cites W2005410572 @default.
• W3092079205 cites W2007302457 @default.
• W3092079205 cites W2008172359 @default.
• W3092079205 cites W2011284201 @default.
• W3092079205 cites W2015642279 @default.
• W3092079205 cites W2015695061 @default.
• W3092079205 cites W2021378114 @default.
• W3092079205 cites W2026826794 @default.
• W3092079205 cites W2038362765 @default.
• W3092079205 cites W2043038685 @default.
• W3092079205 cites W2049861380 @default.
• W3092079205 cites W2050152294 @default.
• W3092079205 cites W2065322000 @default.
• W3092079205 cites W2072013249 @default.
• W3092079205 cites W2073196300 @default.
• W3092079205 cites W2074192996 @default.
• W3092079205 cites W2078041280 @default.
• W3092079205 cites W2078446553 @default.
• W3092079205 cites W2081000721 @default.
• W3092079205 cites W2082229999 @default.
• W3092079205 cites W2082484676 @default.
• W3092079205 cites W2082897056 @default.
• W3092079205 cites W2094615848 @default.
• W3092079205 cites W2098457311 @default.
• W3092079205 cites W2099783520 @default.
• W3092079205 cites W2100372406 @default.
• W3092079205 cites W2104127840 @default.
• W3092079205 cites W2109388187 @default.
• W3092079205 cites W2112092248 @default.
• W3092079205 cites W2113027268 @default.
• W3092079205 cites W2118057929 @default.
• W3092079205 cites W2124159210 @default.
• W3092079205 cites W2126212760 @default.
• W3092079205 cites W2128541003 @default.
• W3092079205 cites W2133262115 @default.
• W3092079205 cites W2135346203 @default.
• W3092079205 cites W2138265677 @default.
• W3092079205 cites W2138394378 @default.
• W3092079205 cites W2144395887 @default.
• W3092079205 cites W2147852317 @default.
• W3092079205 cites W2153994826 @default.
• W3092079205 cites W2158154670 @default.
• W3092079205 cites W2161938647 @default.
• W3092079205 cites W2162411731 @default.
• W3092079205 cites W2163358530 @default.
• W3092079205 cites W2163926478 @default.
• W3092079205 cites W2167301808 @default.
• W3092079205 cites W2168480534 @default.
• W3092079205 cites W2169269721 @default.
• W3092079205 cites W2169385982 @default.
• W3092079205 cites W2184458350 @default.
• W3092079205 cites W2193395909 @default.
• W3092079205 cites W2206101718 @default.
• W3092079205 cites W2217732740 @default.
• W3092079205 cites W2275034928 @default.
• W3092079205 cites W2276580523 @default.
• W3092079205 cites W2289669711 @default.
• W3092079205 cites W2336690489 @default.
• W3092079205 cites W2343254659 @default.
• W3092079205 cites W2419140434 @default.
• W3092079205 cites W2464644019 @default.
• W3092079205 cites W2518162073 @default.
• W3092079205 cites W2523202594 @default.
• W3092079205 cites W2527290204 @default.
• W3092079205 cites W2558761368 @default.
• W3092079205 cites W2559537906 @default.

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