FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092107065> ?p ?o ?g. }

• W3092107065 endingPage "737" @default.
• W3092107065 startingPage "732" @default.
• W3092107065 abstract "Quantitative imaging biomarkers are widely used in PET for both research and clinical applications, yet bias in the underlying image data has not been well characterized. In the absence of a readily available reference standard for in vivo quantification, bias in PET images has been inferred using physical phantoms, even though arrangements of this sort provide only a poor approximation of the imaging environment in real patient examinations. In this study, we used data acquired from patient volunteers to assess PET quantitative bias in vivo. Image-derived radioactivity concentrations in the descending aorta were compared with blood samples counted on a calibrated γ-counter. <b>Methods:</b> Ten patients with prostate cancer were studied using 2-(3-(1-carboxy-5-[(6-¹⁸F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid PET/CT. For each patient, 3 whole-body PET/CT image series were acquired after a single administration of the radiotracer: shortly after injection as well as approximately 1 and 4 h later. Venous blood samples were obtained at 8 time points over an 8-h period, and whole blood was counted on a NaI γ-counter. A 10-mm-diameter, 20-mm-long cylindric volume of interest was positioned in the descending thoracic aorta to estimate the PET-derived radioactivity concentration in blood. A triexponential function was fit to the γ-counter blood data and used to estimate the radioactivity concentration at the time of each PET acquisition. <b>Results:</b> The PET-derived and γ-counter–derived radioactivity concentrations were linearly related, with an <i>R</i>² of 0.985, over a range of relevant radioactivity concentrations. The mean difference between the PET and γ-counter data was 4.8% ± 8.6%, with the PET measurements tending to be greater. <b>Conclusion:</b> Human image data acquired on a conventional whole-body PET/CT system with a typical clinical protocol differed by an average of around 5% from blood samples counted on a calibrated γ-counter. This bias may be partly attributable to residual uncorrected scatter or attenuation correction error. These data offer an opportunity for the assessment of PET bias in vivo and provide additional support for the use of quantitative imaging biomarkers." @default.
• W3092107065 created "2020-10-15" @default.
• W3092107065 creator A5000474863 @default.
• W3092107065 creator A5049568817 @default.
• W3092107065 creator A5067187971 @default.
• W3092107065 creator A5069386815 @default.
• W3092107065 creator A5071268553 @default.
• W3092107065 creator A5087520734 @default.
• W3092107065 date "2020-10-09" @default.
• W3092107065 modified "2023-09-25" @default.
• W3092107065 title "Measurement of PET Quantitative Bias In Vivo" @default.
• W3092107065 cites W1602882708 @default.
• W3092107065 cites W161293699 @default.
• W3092107065 cites W1871263388 @default.
• W3092107065 cites W1920105114 @default.
• W3092107065 cites W1966751875 @default.
• W3092107065 cites W1978925250 @default.
• W3092107065 cites W1994463565 @default.
• W3092107065 cites W2002129123 @default.
• W3092107065 cites W2047284752 @default.
• W3092107065 cites W2066514753 @default.
• W3092107065 cites W2079571164 @default.
• W3092107065 cites W2094847554 @default.
• W3092107065 cites W2097567141 @default.
• W3092107065 cites W2103796724 @default.
• W3092107065 cites W2121272153 @default.
• W3092107065 cites W2132038995 @default.
• W3092107065 cites W2141618298 @default.
• W3092107065 cites W2143232354 @default.
• W3092107065 cites W2154852444 @default.
• W3092107065 cites W2159759971 @default.
• W3092107065 cites W2181620286 @default.
• W3092107065 cites W2188489309 @default.
• W3092107065 cites W2194867551 @default.
• W3092107065 cites W2590848133 @default.
• W3092107065 cites W2616489368 @default.
• W3092107065 cites W2782215450 @default.
• W3092107065 cites W2807971451 @default.
• W3092107065 cites W2937075711 @default.
• W3092107065 cites W3000118848 @default.
• W3092107065 cites W98549894 @default.
• W3092107065 doi "https://doi.org/10.2967/jnumed.120.251397" @default.
• W3092107065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33037089" @default.
• W3092107065 hasPublicationYear "2020" @default.
• W3092107065 type Work @default.
• W3092107065 sameAs 3092107065 @default.
• W3092107065 citedByCount "3" @default.
• W3092107065 countsByYear W30921070652021 @default.
• W3092107065 countsByYear W30921070652022 @default.
• W3092107065 countsByYear W30921070652023 @default.
• W3092107065 crossrefType "journal-article" @default.
• W3092107065 hasAuthorship W3092107065A5000474863 @default.
• W3092107065 hasAuthorship W3092107065A5049568817 @default.
• W3092107065 hasAuthorship W3092107065A5067187971 @default.
• W3092107065 hasAuthorship W3092107065A5069386815 @default.
• W3092107065 hasAuthorship W3092107065A5071268553 @default.
• W3092107065 hasAuthorship W3092107065A5087520734 @default.
• W3092107065 hasBestOaLocation W30921070651 @default.
• W3092107065 hasConcept C123688308 @default.
• W3092107065 hasConcept C126322002 @default.
• W3092107065 hasConcept C127077266 @default.
• W3092107065 hasConcept C150903083 @default.
• W3092107065 hasConcept C185592680 @default.
• W3092107065 hasConcept C199374082 @default.
• W3092107065 hasConcept C207001950 @default.
• W3092107065 hasConcept C2775842073 @default.
• W3092107065 hasConcept C2779980429 @default.
• W3092107065 hasConcept C2780663194 @default.
• W3092107065 hasConcept C2989005 @default.
• W3092107065 hasConcept C3017724952 @default.
• W3092107065 hasConcept C37557685 @default.
• W3092107065 hasConcept C71924100 @default.
• W3092107065 hasConcept C82233179 @default.
• W3092107065 hasConcept C86803240 @default.
• W3092107065 hasConceptScore W3092107065C123688308 @default.
• W3092107065 hasConceptScore W3092107065C126322002 @default.
• W3092107065 hasConceptScore W3092107065C127077266 @default.
• W3092107065 hasConceptScore W3092107065C150903083 @default.
• W3092107065 hasConceptScore W3092107065C185592680 @default.
• W3092107065 hasConceptScore W3092107065C199374082 @default.
• W3092107065 hasConceptScore W3092107065C207001950 @default.
• W3092107065 hasConceptScore W3092107065C2775842073 @default.
• W3092107065 hasConceptScore W3092107065C2779980429 @default.
• W3092107065 hasConceptScore W3092107065C2780663194 @default.
• W3092107065 hasConceptScore W3092107065C2989005 @default.
• W3092107065 hasConceptScore W3092107065C3017724952 @default.
• W3092107065 hasConceptScore W3092107065C37557685 @default.
• W3092107065 hasConceptScore W3092107065C71924100 @default.
• W3092107065 hasConceptScore W3092107065C82233179 @default.
• W3092107065 hasConceptScore W3092107065C86803240 @default.
• W3092107065 hasIssue "5" @default.
• W3092107065 hasLocation W30921070651 @default.
• W3092107065 hasLocation W30921070652 @default.
• W3092107065 hasLocation W30921070653 @default.
• W3092107065 hasOpenAccess W3092107065 @default.
• W3092107065 hasPrimaryLocation W30921070651 @default.
• W3092107065 hasRelatedWork W1965865508 @default.
• W3092107065 hasRelatedWork W1991553034 @default.

• next