FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092115529> ?p ?o ?g. }

• W3092115529 endingPage "151" @default.
• W3092115529 startingPage "142" @default.
• W3092115529 abstract "The endocrine pancreas comprises the islets of Langerhans, primarily consisting of beta cells, alpha cells and delta cells responsible for secretion of insulin, glucagon and somatostatin, respectively. A certain level of intra-islet communication is thought to exist, where the individual hormones may reach the other islet cells and regulate their secretion. Glucagon has been demonstrated to importantly regulate insulin secretion, while somatostatin powerfully inhibits both insulin and glucagon secretion. In this study we investigated how secretion of somatostatin is regulated by paracrine signalling from glucagon and insulin.Somatostatin secretion was measured from perfused mouse pancreases isolated from wild-type as well as diphtheria toxin-induced alpha cell knockdown, and global glucagon receptor knockout (Gcgr-/-) mice. We studied the effects of varying glucose concentrations together with infusions of arginine, glucagon, insulin and somatostatin, as well as infusions of antagonists of insulin, somatostatin and glucagon-like peptide 1 (GLP-1) receptors.A tonic inhibitory role of somatostatin was demonstrated with infusion of somatostatin receptor antagonists, which significantly increased glucagon secretion at low and high glucose, whereas insulin secretion was only increased at high glucose levels. Infusion of glucagon dose-dependently increased somatostatin secretion approximately twofold in control mice. Exogenous glucagon had no effect on somatostatin secretion in Gcgr-/- mice, and a reduced effect when combined with the GLP-1 receptor antagonist exendin 9-39. Diphtheria toxin-induced knockdown of glucagon producing cells led to reduced somatostatin secretion in response to 12 mmol/l glucose and arginine infusions. In Gcgr-/- mice (where glucagon levels are dramatically increased) overall somatostatin secretion was increased. However, infusion of exendin 9-39 in Gcgr-/- mice completely abolished somatostatin secretion in response to glucose and arginine. Neither insulin nor an insulin receptor antagonist (S961) had any effect on somatostatin secretion.Our findings demonstrate that somatostatin and glucagon secretion are linked in a reciprocal feedback cycle with somatostatin inhibiting glucagon secretion at low and high glucose levels, and glucagon stimulating somatostatin secretion via the glucagon and GLP-1 receptors. Graphical abstract." @default.
• W3092115529 created "2020-10-15" @default.
• W3092115529 creator A5016262814 @default.
• W3092115529 creator A5085434984 @default.
• W3092115529 date "2020-10-12" @default.
• W3092115529 modified "2023-09-30" @default.
• W3092115529 title "Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets" @default.
• W3092115529 cites W1964872621 @default.
• W3092115529 cites W1968987200 @default.
• W3092115529 cites W1971242316 @default.
• W3092115529 cites W1984541901 @default.
• W3092115529 cites W1992753036 @default.
• W3092115529 cites W1994867775 @default.
• W3092115529 cites W2003946536 @default.
• W3092115529 cites W2013314407 @default.
• W3092115529 cites W2014243511 @default.
• W3092115529 cites W2025948279 @default.
• W3092115529 cites W2026421902 @default.
• W3092115529 cites W2033204276 @default.
• W3092115529 cites W2033228124 @default.
• W3092115529 cites W2039655206 @default.
• W3092115529 cites W2048903649 @default.
• W3092115529 cites W2059905516 @default.
• W3092115529 cites W2070930548 @default.
• W3092115529 cites W2074528335 @default.
• W3092115529 cites W2075594039 @default.
• W3092115529 cites W2078245629 @default.
• W3092115529 cites W2098353128 @default.
• W3092115529 cites W2110468437 @default.
• W3092115529 cites W2127167047 @default.
• W3092115529 cites W2146956768 @default.
• W3092115529 cites W2148438875 @default.
• W3092115529 cites W2150567837 @default.
• W3092115529 cites W2155450095 @default.
• W3092115529 cites W2157610243 @default.
• W3092115529 cites W2164739927 @default.
• W3092115529 cites W2169718622 @default.
• W3092115529 cites W2332355444 @default.
• W3092115529 cites W2336448570 @default.
• W3092115529 cites W2346764160 @default.
• W3092115529 cites W2416327809 @default.
• W3092115529 cites W2460804009 @default.
• W3092115529 cites W2886098455 @default.
• W3092115529 cites W2888657962 @default.
• W3092115529 cites W2899339394 @default.
• W3092115529 cites W2910978360 @default.
• W3092115529 cites W2914141586 @default.
• W3092115529 doi "https://doi.org/10.1007/s00125-020-05288-0" @default.
• W3092115529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33043402" @default.
• W3092115529 hasPublicationYear "2020" @default.
• W3092115529 type Work @default.
• W3092115529 sameAs 3092115529 @default.
• W3092115529 citedByCount "24" @default.
• W3092115529 countsByYear W30921155292021 @default.
• W3092115529 countsByYear W30921155292022 @default.
• W3092115529 countsByYear W30921155292023 @default.
• W3092115529 crossrefType "journal-article" @default.
• W3092115529 hasAuthorship W3092115529A5016262814 @default.
• W3092115529 hasAuthorship W3092115529A5085434984 @default.
• W3092115529 hasBestOaLocation W30921155291 @default.
• W3092115529 hasConcept C126322002 @default.
• W3092115529 hasConcept C134018914 @default.
• W3092115529 hasConcept C152091265 @default.
• W3092115529 hasConcept C165220095 @default.
• W3092115529 hasConcept C185592680 @default.
• W3092115529 hasConcept C2776297358 @default.
• W3092115529 hasConcept C2776828364 @default.
• W3092115529 hasConcept C2777300450 @default.
• W3092115529 hasConcept C2778542361 @default.
• W3092115529 hasConcept C2778563252 @default.
• W3092115529 hasConcept C2779306644 @default.
• W3092115529 hasConcept C71924100 @default.
• W3092115529 hasConcept C86803240 @default.
• W3092115529 hasConceptScore W3092115529C126322002 @default.
• W3092115529 hasConceptScore W3092115529C134018914 @default.
• W3092115529 hasConceptScore W3092115529C152091265 @default.
• W3092115529 hasConceptScore W3092115529C165220095 @default.
• W3092115529 hasConceptScore W3092115529C185592680 @default.
• W3092115529 hasConceptScore W3092115529C2776297358 @default.
• W3092115529 hasConceptScore W3092115529C2776828364 @default.
• W3092115529 hasConceptScore W3092115529C2777300450 @default.
• W3092115529 hasConceptScore W3092115529C2778542361 @default.
• W3092115529 hasConceptScore W3092115529C2778563252 @default.
• W3092115529 hasConceptScore W3092115529C2779306644 @default.
• W3092115529 hasConceptScore W3092115529C71924100 @default.
• W3092115529 hasConceptScore W3092115529C86803240 @default.
• W3092115529 hasFunder F4320320870 @default.
• W3092115529 hasFunder F4320321999 @default.
• W3092115529 hasFunder F4320322928 @default.
• W3092115529 hasFunder F4320325957 @default.
• W3092115529 hasIssue "1" @default.
• W3092115529 hasLocation W30921155291 @default.
• W3092115529 hasLocation W30921155292 @default.
• W3092115529 hasOpenAccess W3092115529 @default.
• W3092115529 hasPrimaryLocation W30921155291 @default.
• W3092115529 hasRelatedWork W1979462991 @default.
• W3092115529 hasRelatedWork W1995945960 @default.
• W3092115529 hasRelatedWork W2017797235 @default.

• next