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- W3092117505 endingPage "579" @default.
- W3092117505 startingPage "569" @default.
- W3092117505 abstract "Tibial dyschondroplasia (TD) is an intractable avian bone disease that causes severe poultry economic losses. The pathogenicity of TD is unknown. Therefore, TD disease has not been evacuated yet. Based on continuous research findings, we have gone through the molecular and cellular insight into the TD and proposed possible pathogenicity for future studies. Immunity and angiogenesis-related genes expressed in the erythrocytes of chicken, influenced the apoptosis of chicken chondrocytes to cause TD. TD could be defined as the irregular, unmineralized and un-vascularized mass of cartilage, which is caused by apoptosis, degeneration and insufficient blood supply at the site of the chicken growth plate. The failure of angiogenesis attributed improper nutrients supply to the chondrocytes; ultimately, bone development stopped, poor calcification of cartilage matrix , and apoptosis of chondrocytes occurred. Recent studies explore potential signaling pathways that regulated TD in broiler chickens , including parathyroid hormone-related peptide (PTHrP), transforming growth factor β (TGF- β)/bone morphogenic proteins (BMPs), and hypoxia-inducible factor (HIF). Several studies have reported many medicines to treat TD. However, recently, rGSTA3 protein (50 μg·kg −1 ) is considered the most proper TD treatment. The present review has summarized the molecular and cellular insight into the TD, which will help researchers in medicine development to evacuate TD completely. • TD is an important undetected avian growth plate disease and the exact reason of pathogenesis has not yet been found. • TD cause huge economic losses to the poultry industry and endangering the health of poultry. • Screened transcriptome analysis related to the broiler growth plates has been addressed for future research. • This review has provided a comprehensive overview of TD in accordance to the cellular and molecular mechanism. • rGSTA3 protein in thiram induced TD chickens may prevent the chondrocytes' death." @default.
- W3092117505 created "2020-10-15" @default.
- W3092117505 creator A5004634878 @default.
- W3092117505 creator A5022801365 @default.
- W3092117505 date "2021-03-01" @default.
- W3092117505 modified "2023-10-17" @default.
- W3092117505 title "Cellular, molecular and genetical overview of avian tibial dyschondroplasia" @default.
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