Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092157691> ?p ?o ?g. }
- W3092157691 endingPage "e814" @default.
- W3092157691 startingPage "e806" @default.
- W3092157691 abstract "Abstract Background Prolonged enteropathogen shedding after diarrhea complicates the identification of etiology in subsequent episodes and is an important driver of pathogen transmission. A standardized approach has not been applied to estimate the duration of shedding for a wide range of pathogens. Methods We used a multisite birth cohort of children 0–24 months of age from whom diarrheal and monthly nondiarrheal stools were previously tested by quantitative polymerase chain reaction for 29 enteropathogens. We modeled the probability of detection of the etiologic pathogen before and after diarrhea using a log-normal accelerated failure time survival model and estimated the median duration of pathogen carriage as well as differences in subclinical pathogen carriage 60 days after diarrhea onset in comparison to a prediarrhea baseline. Results We analyzed 3247 etiologic episodes of diarrhea for the 9 pathogens with the highest attributable burdens of diarrhea. The median duration of postdiarrheal carriage varied widely by pathogen, from about 1 week for rotavirus (median, 8.1 days [95% confidence interval {CI}, 6.2–9.6]) to >1 month for Cryptosporidium (39.5 days [95% CI, 30.6–49.0]). The largest increases in subclinical pathogen carriage before and after diarrhea were seen for Cryptosporidium (prevalence difference between 30 days prior and 60 days after diarrhea onset, 0.30 [95% CI, .23–.39]) and Shigella (prevalence difference, 0.21 [95% CI, .16–.27]). Conclusions Postdiarrheal shedding was widely variable between pathogens, with strikingly prolonged shedding seen for Cryptosporidium and Shigella. Targeted antimicrobial therapy and vaccination for these pathogens may have a relatively large impact on transmission." @default.
- W3092157691 created "2020-10-15" @default.
- W3092157691 creator A5000337740 @default.
- W3092157691 creator A5007061685 @default.
- W3092157691 creator A5008790762 @default.
- W3092157691 creator A5011452638 @default.
- W3092157691 creator A5027604397 @default.
- W3092157691 creator A5029192747 @default.
- W3092157691 creator A5039433364 @default.
- W3092157691 creator A5040110563 @default.
- W3092157691 creator A5043938728 @default.
- W3092157691 creator A5051239535 @default.
- W3092157691 creator A5051818098 @default.
- W3092157691 creator A5055187184 @default.
- W3092157691 creator A5068198671 @default.
- W3092157691 creator A5071421003 @default.
- W3092157691 creator A5083478362 @default.
- W3092157691 creator A5084152395 @default.
- W3092157691 creator A5084419236 @default.
- W3092157691 creator A5085352453 @default.
- W3092157691 creator A5087299636 @default.
- W3092157691 date "2020-10-09" @default.
- W3092157691 modified "2023-10-15" @default.
- W3092157691 title "Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings" @default.
- W3092157691 cites W1731548184 @default.
- W3092157691 cites W1821981622 @default.
- W3092157691 cites W1989508672 @default.
- W3092157691 cites W2009108954 @default.
- W3092157691 cites W2044661406 @default.
- W3092157691 cites W2052452124 @default.
- W3092157691 cites W2058348183 @default.
- W3092157691 cites W2078497184 @default.
- W3092157691 cites W2104599301 @default.
- W3092157691 cites W2106742846 @default.
- W3092157691 cites W2108768412 @default.
- W3092157691 cites W2115182954 @default.
- W3092157691 cites W2125283487 @default.
- W3092157691 cites W2127264824 @default.
- W3092157691 cites W2135298445 @default.
- W3092157691 cites W2136334335 @default.
- W3092157691 cites W2150169200 @default.
- W3092157691 cites W2153522309 @default.
- W3092157691 cites W2172111132 @default.
- W3092157691 cites W2239735144 @default.
- W3092157691 cites W2340017293 @default.
- W3092157691 cites W2460389469 @default.
- W3092157691 cites W2521607002 @default.
- W3092157691 cites W2527735051 @default.
- W3092157691 cites W2564207700 @default.
- W3092157691 cites W2748865290 @default.
- W3092157691 cites W2795318775 @default.
- W3092157691 cites W2803243461 @default.
- W3092157691 cites W2807639495 @default.
- W3092157691 cites W2883107330 @default.
- W3092157691 cites W2883180562 @default.
- W3092157691 cites W2892815535 @default.
- W3092157691 cites W2893167551 @default.
- W3092157691 cites W4244563692 @default.
- W3092157691 doi "https://doi.org/10.1093/cid/ciaa1528" @default.
- W3092157691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8315229" @default.
- W3092157691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33033835" @default.
- W3092157691 hasPublicationYear "2020" @default.
- W3092157691 type Work @default.
- W3092157691 sameAs 3092157691 @default.
- W3092157691 citedByCount "22" @default.
- W3092157691 countsByYear W30921576912021 @default.
- W3092157691 countsByYear W30921576912022 @default.
- W3092157691 countsByYear W30921576912023 @default.
- W3092157691 crossrefType "journal-article" @default.
- W3092157691 hasAuthorship W3092157691A5000337740 @default.
- W3092157691 hasAuthorship W3092157691A5007061685 @default.
- W3092157691 hasAuthorship W3092157691A5008790762 @default.
- W3092157691 hasAuthorship W3092157691A5011452638 @default.
- W3092157691 hasAuthorship W3092157691A5027604397 @default.
- W3092157691 hasAuthorship W3092157691A5029192747 @default.
- W3092157691 hasAuthorship W3092157691A5039433364 @default.
- W3092157691 hasAuthorship W3092157691A5040110563 @default.
- W3092157691 hasAuthorship W3092157691A5043938728 @default.
- W3092157691 hasAuthorship W3092157691A5051239535 @default.
- W3092157691 hasAuthorship W3092157691A5051818098 @default.
- W3092157691 hasAuthorship W3092157691A5055187184 @default.
- W3092157691 hasAuthorship W3092157691A5068198671 @default.
- W3092157691 hasAuthorship W3092157691A5071421003 @default.
- W3092157691 hasAuthorship W3092157691A5083478362 @default.
- W3092157691 hasAuthorship W3092157691A5084152395 @default.
- W3092157691 hasAuthorship W3092157691A5084419236 @default.
- W3092157691 hasAuthorship W3092157691A5085352453 @default.
- W3092157691 hasAuthorship W3092157691A5087299636 @default.
- W3092157691 hasBestOaLocation W30921576911 @default.
- W3092157691 hasConcept C113280763 @default.
- W3092157691 hasConcept C126322002 @default.
- W3092157691 hasConcept C137627325 @default.
- W3092157691 hasConcept C142724271 @default.
- W3092157691 hasConcept C203014093 @default.
- W3092157691 hasConcept C2776460866 @default.
- W3092157691 hasConcept C2776986154 @default.
- W3092157691 hasConcept C2778877831 @default.
- W3092157691 hasConcept C2779802037 @default.