Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092160979> ?p ?o ?g. }
- W3092160979 endingPage "118582" @default.
- W3092160979 startingPage "118582" @default.
- W3092160979 abstract "Depression is a common aspect of the modern lifestyle, and most patients are recalcitrant to the current antidepressants. Fingolimod (FTY720), a sphingosine analogue approved for the treatment of multiple sclerosis, has a significant neuroprotective effect on the central nervous system. The aim of this study was to determine the potential therapeutic effect of FTY720 on the behavior and cognitive function of rats exposed daily to chronic unpredictable mild stress (CUMS), and elucidate the underlying mechanisms. The 42-day CUMS modeling induced depression-like behavior as indicated by the scores of sugar water preference, forced swimming, open field and Morris water maze tests. Mechanistically, CUMS caused significant damage to the hippocampal neurons, increased inflammation and oxidative stress, activated the NF-κB/NLRP3 axis, and skewed microglial polarization to the M1 phenotype. FTY720 not only alleviated neuronal damage and oxidative stress, but also improved the depression-like behavior and cognitive function of the rats. It also inhibited NF-κB activation and blocked NLRP3 inflammasome assembly by down-regulating NLRP3, ACS and caspase-1. Furthermore, FTY720 inhibited the microglial M1 polarization markers iNOS and CD16, and promoted the M2 markers Arg-1 and CD206. This in turn reduced the levels of TNF-α, IL-6 and IL-1β, and increased that of IL-10 in the hippocampus. In conclusion, FTY720 protects hippocampal neurons from stress-induced damage and alleviates depressive symptoms by inhibiting neuroinflammation. Our study provides a theoretical basis for S1P receptor modulation in treating depression." @default.
- W3092160979 created "2020-10-15" @default.
- W3092160979 creator A5006380388 @default.
- W3092160979 creator A5008608315 @default.
- W3092160979 creator A5012188875 @default.
- W3092160979 creator A5019288953 @default.
- W3092160979 creator A5033953382 @default.
- W3092160979 creator A5041908785 @default.
- W3092160979 creator A5051843270 @default.
- W3092160979 creator A5059115393 @default.
- W3092160979 creator A5071075405 @default.
- W3092160979 date "2020-12-01" @default.
- W3092160979 modified "2023-10-18" @default.
- W3092160979 title "Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation" @default.
- W3092160979 cites W1543741818 @default.
- W3092160979 cites W1929282196 @default.
- W3092160979 cites W1964744961 @default.
- W3092160979 cites W1969412681 @default.
- W3092160979 cites W1981164474 @default.
- W3092160979 cites W1984615306 @default.
- W3092160979 cites W1986678411 @default.
- W3092160979 cites W1991863806 @default.
- W3092160979 cites W2003438800 @default.
- W3092160979 cites W2005886168 @default.
- W3092160979 cites W2013555370 @default.
- W3092160979 cites W2024215619 @default.
- W3092160979 cites W2024448645 @default.
- W3092160979 cites W2030400690 @default.
- W3092160979 cites W2039056175 @default.
- W3092160979 cites W2042637953 @default.
- W3092160979 cites W2045757893 @default.
- W3092160979 cites W2046363166 @default.
- W3092160979 cites W2058267476 @default.
- W3092160979 cites W2061295164 @default.
- W3092160979 cites W2064965507 @default.
- W3092160979 cites W2072115374 @default.
- W3092160979 cites W2092146811 @default.
- W3092160979 cites W2104205224 @default.
- W3092160979 cites W2115563225 @default.
- W3092160979 cites W2142808413 @default.
- W3092160979 cites W2145910522 @default.
- W3092160979 cites W2155173051 @default.
- W3092160979 cites W2157072257 @default.
- W3092160979 cites W2201607793 @default.
- W3092160979 cites W2312559864 @default.
- W3092160979 cites W2314113836 @default.
- W3092160979 cites W2332193566 @default.
- W3092160979 cites W2418813771 @default.
- W3092160979 cites W2511946169 @default.
- W3092160979 cites W2527763513 @default.
- W3092160979 cites W2578653340 @default.
- W3092160979 cites W2594211197 @default.
- W3092160979 cites W2595165076 @default.
- W3092160979 cites W2601060207 @default.
- W3092160979 cites W2741935991 @default.
- W3092160979 cites W2755118786 @default.
- W3092160979 cites W2757148163 @default.
- W3092160979 cites W2767816611 @default.
- W3092160979 cites W2787368117 @default.
- W3092160979 cites W2788337440 @default.
- W3092160979 cites W2789609881 @default.
- W3092160979 cites W2794169913 @default.
- W3092160979 cites W2794843585 @default.
- W3092160979 cites W2802032956 @default.
- W3092160979 cites W2805805579 @default.
- W3092160979 cites W2883404846 @default.
- W3092160979 cites W2884416729 @default.
- W3092160979 cites W2887660912 @default.
- W3092160979 cites W2890102036 @default.
- W3092160979 cites W2900937351 @default.
- W3092160979 cites W2908045260 @default.
- W3092160979 cites W2912070790 @default.
- W3092160979 cites W2941640355 @default.
- W3092160979 cites W2944076834 @default.
- W3092160979 cites W2948346504 @default.
- W3092160979 cites W2949260900 @default.
- W3092160979 cites W2949818647 @default.
- W3092160979 cites W2969287153 @default.
- W3092160979 cites W2969302992 @default.
- W3092160979 cites W2980655754 @default.
- W3092160979 cites W2991192199 @default.
- W3092160979 cites W2999674087 @default.
- W3092160979 cites W3009757213 @default.
- W3092160979 doi "https://doi.org/10.1016/j.lfs.2020.118582" @default.
- W3092160979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33058911" @default.
- W3092160979 hasPublicationYear "2020" @default.
- W3092160979 type Work @default.
- W3092160979 sameAs 3092160979 @default.
- W3092160979 citedByCount "26" @default.
- W3092160979 countsByYear W30921609792021 @default.
- W3092160979 countsByYear W30921609792022 @default.
- W3092160979 countsByYear W30921609792023 @default.
- W3092160979 crossrefType "journal-article" @default.
- W3092160979 hasAuthorship W3092160979A5006380388 @default.
- W3092160979 hasAuthorship W3092160979A5008608315 @default.
- W3092160979 hasAuthorship W3092160979A5012188875 @default.
- W3092160979 hasAuthorship W3092160979A5019288953 @default.
- W3092160979 hasAuthorship W3092160979A5033953382 @default.