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- W3092177084 endingPage "530" @default.
- W3092177084 startingPage "501" @default.
- W3092177084 abstract "Cytochrome P450 enzymes (P450 enzymes) are the most common and important phase I metabolic enzymes and are responsible for the majority of the metabolism of clinical drugs and other xenobiotics. Drug-drug interactions (DDIs) can occur when the activities of P450 enzymes are inhibited. In particular, irreversible inhibition of P450 enzymes may lead to severe adverse interactions, compared to reversible inhibition. Many natural products have been shown to be irreversible inhibitors of P450 enzymes. The risks for intake of naturally occurring irreversible P450 enzyme inhibitors have been rising due to the rapid growth of the global consumption of natural products. Irreversible inhibition is usually called mechanism-based inactivation, which is time-, concentration- and NADPH- dependent. Generally, the formation of electrophilic intermediates is fundamental for the inactivation of P450 enzymes. This review comprehensively classifies natural P450 enzyme inactivators, including terpenoids, phenylpropanoids, flavonoids, alkaloids, and quinones obtained from herbs or foods. Moreover, the structure − activity correlations according to the IC50 (or Ki) values reported in the literature as well as the underlying mechanisms based on metabolic activation are highlighted in depth." @default.
- W3092177084 created "2020-10-15" @default.
- W3092177084 creator A5005972846 @default.
- W3092177084 creator A5012986583 @default.
- W3092177084 creator A5022959471 @default.
- W3092177084 creator A5034614965 @default.
- W3092177084 creator A5065076323 @default.
- W3092177084 date "2020-10-01" @default.
- W3092177084 modified "2023-10-14" @default.
- W3092177084 title "Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation" @default.
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