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- W3092180854 abstract "Tuberculosis (TB) is one of the most important infectious diseases worldwide. Understanding the transmission of MTB is essential to analyze and propose control strategies, and to monitor drug resistance spread. Ecuador is a middle burden country for tuberculosis with 7,200 new cases per year and 490 deaths associated with TB per year. In this research, MTB isolates circulating in the province of El Oro, on the border of Ecuador and Peru were studied to address its potential transnational transmission. Seventy-one strains collected between the 2012 and 2016 years were genotyped by the 24-loci mycobacterial interspersed repetitive units (MIRU-VNTR) and compared to strains from Ecuador and Peru, respectively. Besides, this research included a study of the prevalence of drug resistance of MTB strains in the province of El Oro. The analysis of the results of the genotyping method (24-loci MIRU-VNTR) allows establishing the presence of genotypically related MTB strains. These strains will form clonal complexes and clusters. The comparative analysis with Ecuador showed twenty clonal complexes (CC) comprising four CC between strains of El Oro and Ecuador, two CC with strains of El Oro, and fourteen CC with strains of Ecuador. While the analysis with Peru showed twenty-two clonal complexes that comprise three CC with strains of El Oro and nineteen CC with strains of Peru, without finding any clustering between El Oro and Peru. Genotyping by MIRU-VNTR (24-loci) revealed one (1.41%) lineage 2 - Beijing family, twenty (28.17%) lineages 4 - LAM family, eight (11.27%) lineages 4 - X family, one (1.41%) lineage 4 - S family, nine (12.68%) lineages 4 - Haarlem family and thirteen (18.31%) lineages 4 - T family. Drug resistance was detected in 42 (59.15%) isolates, and all were found to have primary resistance; among these, twelve (16.90%) were resistant to isoniazid, nine (12.68%) to rifampin, eight (11.27%) to streptomycin, two (2.82%) to ethambutol, two (2.82 %) to pyrazinamide, and nine (12.68%) multiple drug resistant (isoniazid and rifampin). In summary, the results showed that there are no clusters between the strains of the border region (El Oro) and Peru, indicating that there is no recent active transmission with Peru compared to Ecuador." @default.
- W3092180854 created "2020-10-15" @default.
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- W3092180854 date "2020-07-01" @default.
- W3092180854 modified "2023-10-18" @default.
- W3092180854 title "Genomic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in El Oro province (Ecuador)" @default.
- W3092180854 hasPublicationYear "2020" @default.
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