Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092187082> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3092187082 endingPage "329" @default.
- W3092187082 startingPage "325" @default.
- W3092187082 abstract "The patient non-compliance and emergence of multidrug resistance (MDR) have great influence on the increased incidence of tuberculosis (TB). Nanotechnology-based chemotherapy improves pharmacokinetic behaviour, antimycobacterial efficacy reduces dosing frequency and cost of therapy. The present study, a modified microemulsion technique was utilized for the preparation of first-line antitubercular drugs (ATDs). i.e. rifampicin (RIF), isoniazid (INH) and pyrazinamide (PYZ) loaded solid lipid nanoparticles (SLNs). The morphology, particle size, zeta potential was characterized and antimycobacterial activity was evaluated against Mycobacterium smegmatis mc2 155 (M. smegmatis). The resulting ATDs loaded SLNs were spherical with average particle size 195.1±11.11 nm with negative zeta potential –41.9mV and 0.229 PDI. The percentage encapsulation efficiency of RIF, INH and PYZ were 84.6±2.11, 83.3±3.75 and 76.4±3.83, and loading capacity was found to be 43.8%, 35.4% and 39.7%, respectively. The practical yield was found to be 92.6%. The ATDs loaded SLNs formulation also showed sustained drug release for 24 h. The antimycobacterial activity was greatly enhanced against M. smegmatis, and the minimum inhibitory concentration (MIC) of ATDs loaded SLNs was approximately ten-times more effective as compared to standard drugs and two-times efficacy improvement as compared to a physical mixture of ATDs solution. Drug-free SLNs showed no antimycobacterial effect. It can be concluded that the SLNs are promising vehicles for the antimycobacterial activity of ATDs." @default.
- W3092187082 created "2020-10-15" @default.
- W3092187082 creator A5008260763 @default.
- W3092187082 creator A5019466375 @default.
- W3092187082 creator A5020460683 @default.
- W3092187082 creator A5033755439 @default.
- W3092187082 date "2018-01-01" @default.
- W3092187082 modified "2023-09-23" @default.
- W3092187082 title "Investigation of Antimycobacterial potential of solid lipid nanoparticles against M. smegmatis" @default.
- W3092187082 hasPublicationYear "2018" @default.
- W3092187082 type Work @default.
- W3092187082 sameAs 3092187082 @default.
- W3092187082 citedByCount "0" @default.
- W3092187082 crossrefType "journal-article" @default.
- W3092187082 hasAuthorship W3092187082A5008260763 @default.
- W3092187082 hasAuthorship W3092187082A5019466375 @default.
- W3092187082 hasAuthorship W3092187082A5020460683 @default.
- W3092187082 hasAuthorship W3092187082A5033755439 @default.
- W3092187082 hasConcept C142724271 @default.
- W3092187082 hasConcept C155672457 @default.
- W3092187082 hasConcept C171250308 @default.
- W3092187082 hasConcept C176947019 @default.
- W3092187082 hasConcept C178790620 @default.
- W3092187082 hasConcept C185592680 @default.
- W3092187082 hasConcept C192562407 @default.
- W3092187082 hasConcept C199529486 @default.
- W3092187082 hasConcept C2776228421 @default.
- W3092187082 hasConcept C2776967927 @default.
- W3092187082 hasConcept C2777204207 @default.
- W3092187082 hasConcept C2777975735 @default.
- W3092187082 hasConcept C2778607973 @default.
- W3092187082 hasConcept C2779685592 @default.
- W3092187082 hasConcept C2780035454 @default.
- W3092187082 hasConcept C2780459521 @default.
- W3092187082 hasConcept C2781069245 @default.
- W3092187082 hasConcept C4937899 @default.
- W3092187082 hasConcept C501593827 @default.
- W3092187082 hasConcept C55493867 @default.
- W3092187082 hasConcept C71924100 @default.
- W3092187082 hasConcept C86181022 @default.
- W3092187082 hasConcept C98274493 @default.
- W3092187082 hasConceptScore W3092187082C142724271 @default.
- W3092187082 hasConceptScore W3092187082C155672457 @default.
- W3092187082 hasConceptScore W3092187082C171250308 @default.
- W3092187082 hasConceptScore W3092187082C176947019 @default.
- W3092187082 hasConceptScore W3092187082C178790620 @default.
- W3092187082 hasConceptScore W3092187082C185592680 @default.
- W3092187082 hasConceptScore W3092187082C192562407 @default.
- W3092187082 hasConceptScore W3092187082C199529486 @default.
- W3092187082 hasConceptScore W3092187082C2776228421 @default.
- W3092187082 hasConceptScore W3092187082C2776967927 @default.
- W3092187082 hasConceptScore W3092187082C2777204207 @default.
- W3092187082 hasConceptScore W3092187082C2777975735 @default.
- W3092187082 hasConceptScore W3092187082C2778607973 @default.
- W3092187082 hasConceptScore W3092187082C2779685592 @default.
- W3092187082 hasConceptScore W3092187082C2780035454 @default.
- W3092187082 hasConceptScore W3092187082C2780459521 @default.
- W3092187082 hasConceptScore W3092187082C2781069245 @default.
- W3092187082 hasConceptScore W3092187082C4937899 @default.
- W3092187082 hasConceptScore W3092187082C501593827 @default.
- W3092187082 hasConceptScore W3092187082C55493867 @default.
- W3092187082 hasConceptScore W3092187082C71924100 @default.
- W3092187082 hasConceptScore W3092187082C86181022 @default.
- W3092187082 hasConceptScore W3092187082C98274493 @default.
- W3092187082 hasIssue "9" @default.
- W3092187082 hasLocation W30921870821 @default.
- W3092187082 hasOpenAccess W3092187082 @default.
- W3092187082 hasPrimaryLocation W30921870821 @default.
- W3092187082 hasRelatedWork W1972062500 @default.
- W3092187082 hasRelatedWork W1972265773 @default.
- W3092187082 hasRelatedWork W1988578493 @default.
- W3092187082 hasRelatedWork W2031190569 @default.
- W3092187082 hasRelatedWork W2050818239 @default.
- W3092187082 hasRelatedWork W2114205744 @default.
- W3092187082 hasRelatedWork W2302252076 @default.
- W3092187082 hasRelatedWork W2469608520 @default.
- W3092187082 hasRelatedWork W2884946551 @default.
- W3092187082 hasRelatedWork W2898274387 @default.
- W3092187082 hasRelatedWork W2907468608 @default.
- W3092187082 hasRelatedWork W2942804183 @default.
- W3092187082 hasRelatedWork W2951404073 @default.
- W3092187082 hasRelatedWork W3007192912 @default.
- W3092187082 hasRelatedWork W3037152456 @default.
- W3092187082 hasRelatedWork W3056563211 @default.
- W3092187082 hasRelatedWork W3087733506 @default.
- W3092187082 hasRelatedWork W3124894219 @default.
- W3092187082 hasRelatedWork W3129678428 @default.
- W3092187082 hasRelatedWork W3096439460 @default.
- W3092187082 hasVolume "7" @default.
- W3092187082 isParatext "false" @default.
- W3092187082 isRetracted "false" @default.
- W3092187082 magId "3092187082" @default.
- W3092187082 workType "article" @default.