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- W3092192015 abstract "Background: ISGPS classification of Post-Operative Pancreatic Fistula (POPF) was recently revised, introducing the concept of Biochemical Leakage (BL), which replaced the grade A POPF. More recently, an additional distinction on three different subclasses for grade B (B1-B3) POPF was proposed. The aim of this study was to evaluate the impact of these modifications in clinical practice. Materials and Methods: All Pancreatico-Duodenectomies (PD) and Distal Pancreatectomies (DP) performed between 2010-2016 were retrospectively evaluated. Incidence and grade of POPF using the old and new ISGPS classification were evaluated. Three grade B subclasses (B1: maintenance of abdominal drain > 3 weeks; B2: adoption of specific medical treatments for POPF; B3: use of radiological procedures) were evaluated for clinical severity. Results: 716 patients (502 PD, 214 DP) were evaluated. New ISGPS classification reduced the reported rate of POPF (30.7% vs 35.2% for PD, p > 0.05; 28% vs 44.9% for DP, p < 0.05), due to the abolition of grade A POPF. Grade B1, B2 and B3 rate were 3.1%, 73.8% and 23.1% in PD and 12.3%, 47.4% and 40.3% in DP, respectively. Passing from B1 to B3, a significant increase of wound infection (from 0% to 40.0%) and mean length of stay (from 14.7 to 22.5 days) (p < 0.05) in PD and of readmission rate (from 0% to 39.1%) in DP was observed. Conclusions: New ISGPS classification significantly reduces the reported rate of POPF, particularly after DP. The three different grade B subclasses (B1-B3) better discriminate the severity of post-operative course, particularly after PD." @default.
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- W3092192015 date "2020-01-01" @default.
- W3092192015 modified "2023-09-26" @default.
- W3092192015 title "The evolution of Post-Operative Pancreatic Fistula (POPF) classification: a single-center experience." @default.
- W3092192015 doi "https://doi.org/10.1016/j.hpb.2020.04.166" @default.
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