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- W3092206475 abstract "Tumor-associated macrophages (TAMs) can exist in pro- and anti-inflammatory states. Anti-inflammatory TAMs (also referred to as M2-polarized) generally suppress antitumor immune responses and enhance the metastatic progression of cancer. To explore the mechanisms behind this phenomenon, we isolated macrophages from mice and humans, polarized them ex vivo, and examined their functional interaction with breast cancer cells in culture and in mice. We found that anti-inflammatory TAMs promoted a metabolic state in breast cancer cells that supported various protumorigenic phenotypes. Anti-inflammatory TAMs secreted the cytokine TGF-β that, upon engagement of its receptors in breast cancer cells, suppressed the abundance of the transcription factor STAT1 and, consequently, decreased that of the metabolic enzyme succinate dehydrogenase (SDH) in the tumor cells. The decrease in SDH levels in tumor cells resulted in an accumulation of succinate, which enhanced the stability of the transcription factor HIF1α and reprogrammed cell metabolism to a glycolytic state. TAM depletion-repletion experiments in a 4T1 mouse model additionally revealed that anti-inflammatory macrophages promoted HIF-associated vascularization and expression of the immunosuppressive protein PD-L1 in tumors. The findings suggest that anti-inflammatory TAMs promote tumor-associated angiogenesis and immunosuppression by altering metabolism in breast cancer cells." @default.
- W3092206475 created "2020-10-15" @default.
- W3092206475 creator A5002177625 @default.
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- W3092206475 date "2020-10-06" @default.
- W3092206475 modified "2023-10-09" @default.
- W3092206475 title "Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells" @default.
- W3092206475 cites W1457625536 @default.
- W3092206475 cites W1480357432 @default.
- W3092206475 cites W1483430612 @default.
- W3092206475 cites W1583764915 @default.
- W3092206475 cites W1643432417 @default.
- W3092206475 cites W1656799253 @default.
- W3092206475 cites W1971620413 @default.
- W3092206475 cites W1980485314 @default.
- W3092206475 cites W1984413324 @default.
- W3092206475 cites W1991808539 @default.
- W3092206475 cites W1997719110 @default.
- W3092206475 cites W2000217512 @default.
- W3092206475 cites W2001717792 @default.
- W3092206475 cites W2003842905 @default.
- W3092206475 cites W2004183689 @default.
- W3092206475 cites W2011810742 @default.
- W3092206475 cites W2018008610 @default.
- W3092206475 cites W2037489902 @default.
- W3092206475 cites W2038781914 @default.
- W3092206475 cites W2057199368 @default.
- W3092206475 cites W2057262009 @default.
- W3092206475 cites W2057445229 @default.
- W3092206475 cites W2058648826 @default.
- W3092206475 cites W2058837304 @default.
- W3092206475 cites W2063464619 @default.
- W3092206475 cites W2063632665 @default.
- W3092206475 cites W2065219295 @default.
- W3092206475 cites W2066671159 @default.
- W3092206475 cites W2068819405 @default.
- W3092206475 cites W2070855360 @default.
- W3092206475 cites W2072451938 @default.
- W3092206475 cites W2077731584 @default.
- W3092206475 cites W2080032941 @default.
- W3092206475 cites W2080860848 @default.
- W3092206475 cites W2083814145 @default.
- W3092206475 cites W2097259163 @default.
- W3092206475 cites W2100413206 @default.
- W3092206475 cites W2104852749 @default.
- W3092206475 cites W2105156168 @default.
- W3092206475 cites W2106991692 @default.
- W3092206475 cites W2108036428 @default.
- W3092206475 cites W2116622745 @default.
- W3092206475 cites W2117692326 @default.
- W3092206475 cites W2120944127 @default.
- W3092206475 cites W2125782175 @default.
- W3092206475 cites W2129311237 @default.
- W3092206475 cites W2130522035 @default.
- W3092206475 cites W2136749294 @default.
- W3092206475 cites W2136964874 @default.
- W3092206475 cites W2165734811 @default.
- W3092206475 cites W2167279371 @default.
- W3092206475 cites W2175190582 @default.
- W3092206475 cites W2231680293 @default.
- W3092206475 cites W2234115940 @default.
- W3092206475 cites W2267049176 @default.
- W3092206475 cites W2309280425 @default.
- W3092206475 cites W2337267398 @default.
- W3092206475 cites W2377936835 @default.
- W3092206475 cites W2398235143 @default.
- W3092206475 cites W2519942994 @default.
- W3092206475 cites W2549692453 @default.
- W3092206475 cites W2569614793 @default.
- W3092206475 cites W2583768665 @default.
- W3092206475 cites W2584847307 @default.
- W3092206475 cites W2586320694 @default.
- W3092206475 cites W2610213543 @default.
- W3092206475 cites W2626531388 @default.
- W3092206475 cites W2734148025 @default.
- W3092206475 cites W2743361508 @default.
- W3092206475 cites W2747888169 @default.
- W3092206475 cites W2748217844 @default.
- W3092206475 cites W2754242001 @default.
- W3092206475 cites W2758067903 @default.
- W3092206475 cites W2769890142 @default.
- W3092206475 cites W2770247709 @default.
- W3092206475 cites W2779586130 @default.
- W3092206475 cites W2785041354 @default.
- W3092206475 cites W2799349852 @default.
- W3092206475 cites W2804845336 @default.
- W3092206475 cites W2806165623 @default.
- W3092206475 cites W2895951941 @default.