FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092207907> ?p ?o ?g. }

• W3092207907 endingPage "3225" @default.
• W3092207907 startingPage "3209" @default.
• W3092207907 abstract "COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS and widespread coagulopathy. We propose that COVID-19 pathophysiology is initiated by SARS-CoV-2 gene products, the NSP1 and ORF6 proteins, leading to a catastrophic cascade of failures. These viral components induce signal transducer and activator of transcription 1 (STAT1) dysfunction and compensatory hyperactivation of STAT3. In SARS-CoV-2-infected cells, a positive feedback loop established between STAT3 and plasminogen activator inhibitor-1 (PAI-1) may lead to an escalating cycle of activation in common with the interdependent signaling networks affected in COVID-19. Specifically, PAI-1 upregulation leads to coagulopathy characterized by intravascular thrombi. Overproduced PAI-1 binds to TLR4 on macrophages, inducing the secretion of proinflammatory cytokines and chemokines. The recruitment and subsequent activation of innate immune cells within an infected lung drives the destruction of lung architecture, which leads to the infection of regional endothelial cells and produces a hypoxic environment that further stimulates PAI-1 production. Acute lung injury also activates EGFR and leads to the phosphorylation of STAT3. COVID-19 patients' autopsies frequently exhibit diffuse alveolar damage (DAD) and increased hyaluronan (HA) production which also leads to higher levels of PAI-1. COVID-19 risk factors are consistent with this scenario, as PAI-1 levels are increased in hypertension, obesity, diabetes, cardiovascular diseases, and old age. We discuss the possibility of using various approved drugs, or drugs currently in clinical development, to treat COVID-19. This perspective suggests to enhance STAT1 activity and/or inhibit STAT3 functions for COVID-19 treatment. This might derail the escalating STAT3/PAI-1 cycle central to COVID-19." @default.
• W3092207907 created "2020-10-15" @default.
• W3092207907 creator A5000800493 @default.
• W3092207907 creator A5029115834 @default.
• W3092207907 creator A5051418140 @default.
• W3092207907 creator A5054251357 @default.
• W3092207907 creator A5064165363 @default.
• W3092207907 date "2020-10-09" @default.
• W3092207907 modified "2023-10-06" @default.
• W3092207907 title "An aberrant STAT pathway is central to COVID-19" @default.
• W3092207907 cites W1502093553 @default.
• W3092207907 cites W1518931530 @default.
• W3092207907 cites W1560860164 @default.
• W3092207907 cites W1562354816 @default.
• W3092207907 cites W1578030232 @default.
• W3092207907 cites W1608726413 @default.
• W3092207907 cites W1654674166 @default.
• W3092207907 cites W181093158 @default.
• W3092207907 cites W1820978057 @default.
• W3092207907 cites W1902168152 @default.
• W3092207907 cites W1952271883 @default.
• W3092207907 cites W1966282784 @default.
• W3092207907 cites W1967101451 @default.
• W3092207907 cites W1968828198 @default.
• W3092207907 cites W1981635318 @default.
• W3092207907 cites W1991828048 @default.
• W3092207907 cites W1993145638 @default.
• W3092207907 cites W1993520606 @default.
• W3092207907 cites W1994141757 @default.
• W3092207907 cites W2001326610 @default.
• W3092207907 cites W2002776738 @default.
• W3092207907 cites W2003907005 @default.
• W3092207907 cites W2007841824 @default.
• W3092207907 cites W2008226171 @default.
• W3092207907 cites W2016983859 @default.
• W3092207907 cites W2019514608 @default.
• W3092207907 cites W2019942676 @default.
• W3092207907 cites W202019503 @default.
• W3092207907 cites W2021238456 @default.
• W3092207907 cites W2026435290 @default.
• W3092207907 cites W2028305499 @default.
• W3092207907 cites W2034413738 @default.
• W3092207907 cites W2041788615 @default.
• W3092207907 cites W2044308879 @default.
• W3092207907 cites W2046117118 @default.
• W3092207907 cites W2053583874 @default.
• W3092207907 cites W2060197609 @default.
• W3092207907 cites W2068070201 @default.
• W3092207907 cites W2070851077 @default.
• W3092207907 cites W2072532644 @default.
• W3092207907 cites W2073251313 @default.
• W3092207907 cites W2074346555 @default.
• W3092207907 cites W2085510519 @default.
• W3092207907 cites W2088561726 @default.
• W3092207907 cites W2089587147 @default.
• W3092207907 cites W2090066471 @default.
• W3092207907 cites W2096180943 @default.
• W3092207907 cites W2103667952 @default.
• W3092207907 cites W2104268053 @default.
• W3092207907 cites W2116659218 @default.
• W3092207907 cites W2118316826 @default.
• W3092207907 cites W2120966529 @default.
• W3092207907 cites W2123248911 @default.
• W3092207907 cites W2124508024 @default.
• W3092207907 cites W2129071472 @default.
• W3092207907 cites W2129482492 @default.
• W3092207907 cites W2132226460 @default.
• W3092207907 cites W2132992001 @default.
• W3092207907 cites W2133912767 @default.
• W3092207907 cites W2137035430 @default.
• W3092207907 cites W2140786721 @default.
• W3092207907 cites W2141235890 @default.
• W3092207907 cites W2141277692 @default.
• W3092207907 cites W2145188367 @default.
• W3092207907 cites W2146919918 @default.
• W3092207907 cites W2151489897 @default.
• W3092207907 cites W2153593258 @default.
• W3092207907 cites W2155464214 @default.
• W3092207907 cites W2156333187 @default.
• W3092207907 cites W2157600239 @default.
• W3092207907 cites W2161614179 @default.
• W3092207907 cites W2162790692 @default.
• W3092207907 cites W2165999593 @default.
• W3092207907 cites W2170928419 @default.
• W3092207907 cites W2204739685 @default.
• W3092207907 cites W2212463484 @default.
• W3092207907 cites W2254577386 @default.
• W3092207907 cites W2282036468 @default.
• W3092207907 cites W2308794712 @default.
• W3092207907 cites W2316699811 @default.
• W3092207907 cites W2426965800 @default.
• W3092207907 cites W2440056715 @default.
• W3092207907 cites W2441093478 @default.
• W3092207907 cites W2467020097 @default.
• W3092207907 cites W2468978895 @default.
• W3092207907 cites W2513437066 @default.
• W3092207907 cites W2520466490 @default.
• W3092207907 cites W2548759197 @default.

• next