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- W3092214519 endingPage "4084" @default.
- W3092214519 startingPage "4076" @default.
- W3092214519 abstract "The levels of amyloid peptides in the brain are regulated by a clearance pathway from neurons to the blood-brain barrier. The first step is thought to involve diffusion from the plasma membrane to the interstitium. However, amyloid peptides are hydrophobic and avidly intercalate within membranes. The ABC transporter P-glycoprotein is implicated in the clearance of amyloid peptides across the blood-brain, but its role at neurons is undetermined. We here propose that P-glycoprotein mediates 'exit' of amyloid peptides from neurons. Indeed, amyloid peptides have physicochemical similarities to substrates of P-glycoprotein, but their larger size represents a conundrum. This review probes the plausibility of a mechanism for amyloid peptide transport by P-glycoprotein exploiting evolving biochemical and structural models." @default.
- W3092214519 created "2020-10-15" @default.
- W3092214519 creator A5048584813 @default.
- W3092214519 creator A5051148247 @default.
- W3092214519 creator A5053463680 @default.
- W3092214519 creator A5079062452 @default.
- W3092214519 date "2020-10-20" @default.
- W3092214519 modified "2023-10-16" @default.
- W3092214519 title "Mamma Mia, P‐glycoprotein binds again" @default.
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- W3092214519 doi "https://doi.org/10.1002/1873-3468.13951" @default.
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