Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092214825> ?p ?o ?g. }
- W3092214825 endingPage "1200" @default.
- W3092214825 startingPage "1188" @default.
- W3092214825 abstract "Abstract Men and women can exhibit different pain sensitivities, and many chronic pain conditions are more prevalent in one sex. Although there is evidence of sex differences in the brain, it is not known whether there are sex differences in the organization of large-scale functional brain networks in chronic pain. Here, we used graph theory with modular analysis and machine-learning of resting-state-functional magnetic resonance imaging data from 220 participants: 155 healthy controls and 65 individuals with chronic low back pain due to ankylosing spondylitis, a form of arthritis. We found an extensive overlap in the graph partitions with the major brain intrinsic systems (ie, default mode, central, visual, and sensorimotor modules), but also sex-specific network topological characteristics in healthy people and those with chronic pain. People with chronic pain exhibited higher cross-network connectivity, and sex-specific nodal graph properties changes (ie, hub disruption), some of which were associated with the severity of the chronic pain condition. Females exhibited atypically higher functional segregation in the mid cingulate cortex and subgenual anterior cingulate cortex and lower connectivity in the network with the default mode and frontoparietal modules, whereas males exhibited stronger connectivity with the sensorimotor module. Classification models on nodal graph metrics could classify an individual's sex and whether they have chronic pain with high accuracies (77%-92%). These findings highlight the organizational abnormalities of resting-state-brain networks in people with chronic pain and provide a framework to consider sex-specific pain therapeutics." @default.
- W3092214825 created "2020-10-15" @default.
- W3092214825 creator A5010116515 @default.
- W3092214825 creator A5014102522 @default.
- W3092214825 creator A5019362953 @default.
- W3092214825 creator A5019469277 @default.
- W3092214825 creator A5038121079 @default.
- W3092214825 creator A5057618642 @default.
- W3092214825 creator A5061668822 @default.
- W3092214825 creator A5063131307 @default.
- W3092214825 creator A5069477835 @default.
- W3092214825 creator A5077392038 @default.
- W3092214825 creator A5086280642 @default.
- W3092214825 date "2020-10-08" @default.
- W3092214825 modified "2023-10-08" @default.
- W3092214825 title "Sex differences in brain modular organization in chronic pain" @default.
- W3092214825 cites W1574010683 @default.
- W3092214825 cites W1966756689 @default.
- W3092214825 cites W1968439746 @default.
- W3092214825 cites W1969278445 @default.
- W3092214825 cites W1973490552 @default.
- W3092214825 cites W1978588653 @default.
- W3092214825 cites W1979233603 @default.
- W3092214825 cites W1994801733 @default.
- W3092214825 cites W1997501248 @default.
- W3092214825 cites W1999653836 @default.
- W3092214825 cites W2008607322 @default.
- W3092214825 cites W2016111612 @default.
- W3092214825 cites W2016596542 @default.
- W3092214825 cites W2021947606 @default.
- W3092214825 cites W2027545174 @default.
- W3092214825 cites W2027642651 @default.
- W3092214825 cites W2028850601 @default.
- W3092214825 cites W2038752970 @default.
- W3092214825 cites W2040956707 @default.
- W3092214825 cites W2045895137 @default.
- W3092214825 cites W2047678556 @default.
- W3092214825 cites W2054357557 @default.
- W3092214825 cites W2060360760 @default.
- W3092214825 cites W2064946902 @default.
- W3092214825 cites W2066396738 @default.
- W3092214825 cites W2072579585 @default.
- W3092214825 cites W2077584781 @default.
- W3092214825 cites W2082714165 @default.
- W3092214825 cites W2083570561 @default.
- W3092214825 cites W2084479203 @default.
- W3092214825 cites W2084518320 @default.
- W3092214825 cites W2085502426 @default.
- W3092214825 cites W2085641953 @default.
- W3092214825 cites W2085955270 @default.
- W3092214825 cites W2089572795 @default.
- W3092214825 cites W2089718440 @default.
- W3092214825 cites W2091337721 @default.
- W3092214825 cites W2093972428 @default.
- W3092214825 cites W2095293504 @default.
- W3092214825 cites W2110401381 @default.
- W3092214825 cites W2112090702 @default.
- W3092214825 cites W2113619522 @default.
- W3092214825 cites W2114005480 @default.
- W3092214825 cites W2114050444 @default.
- W3092214825 cites W2120043163 @default.
- W3092214825 cites W2121962606 @default.
- W3092214825 cites W2124449947 @default.
- W3092214825 cites W2124510508 @default.
- W3092214825 cites W2127048411 @default.
- W3092214825 cites W2132957436 @default.
- W3092214825 cites W2142829723 @default.
- W3092214825 cites W2151936673 @default.
- W3092214825 cites W2161515775 @default.
- W3092214825 cites W2164262344 @default.
- W3092214825 cites W2168132586 @default.
- W3092214825 cites W2185640743 @default.
- W3092214825 cites W2209739872 @default.
- W3092214825 cites W2262017781 @default.
- W3092214825 cites W2317708507 @default.
- W3092214825 cites W2470374211 @default.
- W3092214825 cites W2510306587 @default.
- W3092214825 cites W2530925272 @default.
- W3092214825 cites W2544026523 @default.
- W3092214825 cites W2554163959 @default.
- W3092214825 cites W2620702520 @default.
- W3092214825 cites W2767487646 @default.
- W3092214825 cites W2779156588 @default.
- W3092214825 cites W2780203776 @default.
- W3092214825 cites W2784262759 @default.
- W3092214825 cites W2801822511 @default.
- W3092214825 cites W2802448421 @default.
- W3092214825 cites W2808166862 @default.
- W3092214825 cites W2883206457 @default.
- W3092214825 cites W2884518658 @default.
- W3092214825 cites W2891696658 @default.
- W3092214825 cites W2892115143 @default.
- W3092214825 cites W2909142128 @default.
- W3092214825 cites W2914619606 @default.
- W3092214825 cites W2921134818 @default.
- W3092214825 cites W2952574438 @default.
- W3092214825 cites W2952837230 @default.
- W3092214825 cites W2954019805 @default.