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• W3092217994 abstract "Open-top light-sheet (OTLS) microscopes have been developed for user-friendly and versatile high-throughput 3D microscopy of thick specimens. As with all imaging modalities, spatial resolution trades off with imaging and analysis times. A hierarchical multi-scale imaging workflow would therefore be of value for many volumetric microscopy applications. We describe a compact multi-resolution OTLS microscope, enabled by a novel solid immersion meniscus lens (SIMlens), which allows users to rapidly transition between air-based objectives for low- and high-resolution 3D imaging. We demonstrate the utility of this system by showcasing an efficient 3D analysis workflow for a diagnostic pathology application." @default.
• W3092217994 created "2020-10-15" @default.
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• W3092217994 date "2020-10-22" @default.
• W3092217994 modified "2023-10-05" @default.
• W3092217994 title "Multi-resolution open-top light-sheet microscopy to enable efficient 3D pathology workflows" @default.
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• W3092217994 doi "https://doi.org/10.1364/boe.408684" @default.
• W3092217994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7687944" @default.
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