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- W3092222443 abstract "The functional role of calcium signaling in astrocytic remains actively debated. One of the main reasons for such a debate is that the astrocytic calcium dynamics are characterized by high spatiotemporal complexity, which was confirmed by new high resolution imaging techniques. Another reason was the evidence of bi-directional astrocytic regulation of neuronal activity referred as gliotransmission. The biophysical mechanisms of spatiotemporal calcium dynamics in astrocytic are still incompletely clear. In this work we propose detailed multi-compartmental model of calcium signaling in astrocytic process. The model of each compartment describes the spontaneous dynamics of intracellular calcium concentration induced by the calcium entry to the cytosol through plasma membrane from the extracellular space. Compartments are coupled through the diffusion of Ca2+ and IP3. Model represents basic principles of generation and propagation of calcium patterns in spatially distributed structure of astrocytic process. We have investigated the effect of the steady state level of intracellular IP3 concentration on the Ca2+ dynamics in the process. It was shown that the sizes, durations and frequencies of these local calcium waves are directly proportional to the IP 5 concentration." @default.
- W3092222443 created "2020-10-15" @default.
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- W3092222443 date "2020-09-01" @default.
- W3092222443 modified "2023-09-23" @default.
- W3092222443 title "Impact of the steady state IP3 level on the intracellular Ca2+ signaling in spatially distributed model of astrocyte" @default.
- W3092222443 doi "https://doi.org/10.1109/dcnair50402.2020.9216749" @default.
- W3092222443 hasPublicationYear "2020" @default.
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