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• W3092229411 abstract "SARS-CoV-2 pandemic had a huge impact on transfusion services, mostly due to the shortage of blood donors during periods of intense social isolation and the implementation of plasma convalescent protocol, requiring the fast and efficient recruitment of immunized donors for apheresis donation. Due to the fact that the SARS-CoV-2 transfusion transmission risks have never been mitigated, mostly due to the lack of studies specifically designed to address this question, blood centers had to deal with the risks of asymptomatic contaminated donors without knowing the disease risk for the recipients. To date, transfusion transmission of any respiratory virus, including SARS-CoV and the Middle East Respiratory Syndrome (MERS)-CoV, has never been confirmed. Two recent studies evaluated the risks of transmission via blood transfusion of SARS-CoV-2. One has determined that there is no risk of RNA-emia in asymptomatic blood donors, but the sample size was very low [[1]Corman V.M. Rabenau H.F. Adams O. Oberle D. Funk M.B. Keller-Stanislawski B. et al.SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission.Transfusion. 2020; https://doi.org/10.1111/trf.15841Crossref PubMed Scopus (69) Google Scholar]. The other study followed-up recipients of blood products of seven donors who tested positive for SARS-CoV-2 infection 6–15 days following the donation and documented that none developed SARS-CoV-2-related symptoms [[2]Kwon S.Y. Kim E.J. Jung Y.S. Jang J.S. Cho N.S. Post-donation COVID-19 identification in blood donors.Vox Sang. 2020; https://doi.org/10.1111/vox.12925Crossref PubMed Scopus (67) Google Scholar]. Similarly, one study has reported the case of an adult donor of hematopoietic stem cells who was in the incubation period of SARS-CoV-2 infection at the moment of the collection and the recipient had no laboratorial or clinical evidences of infection [[3]Lázaro del Campo P. de Paz Arias R. Ramírez López A. de la Cruz Benito B. Humala Barbier K. et al.No transmission of SARS-CoV-2 in a patient undergoing allogeneic hematopoietic cell transplantation from a matched-related donor with unknown COVID-19.Transfus Apher Sci. 2020; https://doi.org/10.1016/j.transci.2020.102921Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar]. In our service, we had 5 donors who experienced COVID-19 symptoms after donation whose blood products have already been transfused to patients. The time between the donation and the COVID-19-related symptoms varied from 1 to 8 days. Two donors had the COVID-19 diagnosis confirmed by PCR, while 2 confirmed the infection through anti-SARS-CoV-2 immunoassays and 2 had presumptive diagnosis. There were 9 blood products derived from the donations: 6 platelet units, 1 red blood cell unit and 2 granulocyte concentrates. All but one of the 9 recipients were immunosuppressed and none presented COVID-19 related symptoms after the transfusions. Interestingly, one recipient with acute lymphoblastic leukemia was transfused with two granulocytes concentrates stemming from two donors with COVID-19 in the incubation period. This patient was critically ill, but the clinical symptoms have not worsened after the transfusion and COVID-19 RT-PCR was negative in the follow-up. Table1 displays a summary of the donors and patients evaluated in this study.Table 1Summary of the evaluation of the donors exhibiting COVID-19 symptoms and the follow-up of the involved transfused patients.Donor IDRecipient IDTime between donation and transfusionTime between donation and donor COVID-related symptomsTime between donation and donor positive RT-PCRTransfused blood productCharacteristics of the transfusion recipientPost-transfusion follow-up115 days5 days5 daysPlatelets8 years-oldNo fever or other COVID19-related symptomsAcute lymphoblastic leukemia (All)Improvement of clinical symptomsD+7post allogeneic hematopoietic stem cell transplantation [HSCT)Vaso-occlusive disease (VOD)24 days5 days5 daysPlatelets1 year-oldNo fever or other COVID 19-related symptomsNeurologic and Pulmonary tuberculosisImprovement of clinical symptomsCitomegalovirus infection34 days5 days5 daysPlatelets68 years-oldNo fever or other COVID 19-related symptomsMantle lymphoma on chemotherapy242days1 daysPresumptive. diagnosisPlatelets13 years-oldNo fever or other COVID 19-related symptomsAcute lymphoblastic leukemiaDeath I Month laterChronic Intestinal Graft versus Host Diseases52days1 daysPresumptive. DiagnosisPlatelets8 years-oldNo fever or other COVID 19-related symptomsAplastic AnemiaImprovement of clinical symptomsChronic Intestinal Graft versus Host Diseases364 days1 days1 daysWhole Blood2 years-oldNo fever or other COVID 19-related symptomsEnd-stage renal disease47Same days7 daysDiagnosis confirmed by serologyGranulocytes5 years-oldThe patient presented episodes of fever daily, even before the transfusion14 days after begginning of symptomsAcute lymphoblastic leukemiaNo fever or other COVID 19-related symptomsFournier syndrome and sepsis57Same days1 daysDiagnosis confirmed by serologyGranulocytes5 years-oldThe patient presented episodes of fever daily, even before the transfusion14 days after begginning of symptomsAcute lymphoblastic leukemiaNo fever or other COVID 19-related symptomsFournier syndrome and sepsis582 days8 daysDiagnosis confirmed by serologyPlatelets27 years-oldNo fever or other COVID 19-related symptoms14 days after begginning of symptomsBiphenotypic leukemiaImprovement of clinical symptomsInduction Chemotherapy Open table in a new tab In sum, we provide here further evidence that SARS-CoV-2 infection is not transfusion-transmitted. This is very important information for transfusion services, as sheds light to the fact that testing blood donors with immunoassays to detect anti-SARS-CoV-2 antibodies is not recommended unless the goal is to provide an epidemiological overview of the infection. No funding to declare." @default.
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• W3092229411 date "2021-02-01" @default.
• W3092229411 modified "2023-09-26" @default.
• W3092229411 title "COVID-19: Further evidence of no transfusion transmission" @default.
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• W3092229411 doi "https://doi.org/10.1016/j.transci.2020.102961" @default.
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