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• W3092236675 abstract "Abstract Mucosal‐associated invariant T (MAIT) cells are an abundant subset of innate‐like T lymphocytes. MAIT cells are activated by microbial riboflavin‐derived antigens, such as 5‐(2‐oxopropylideneamino)‐6‐ d ‐ribitylaminouracil (5‐OP‐RU), when presented by the major histocompatibility complex (MHC) class I‐related protein (MR1). We have synthesized all stereoisomers of 5‐OP‐RU to investigate the effects of its stereochemistry on the MR1‐dependent MAIT cell activation and MR1 upregulation. The analysis of MAIT cell activation by these 5‐OP‐RU isomers revealed that the stereocenters at the 2’‐ and 3’‐OH groups in the ribityl tail are crucial for the recognition of MAIT‐TCR, whereas that of 4’‐OH group does not significantly affect the regulation of MAIT cell activity. Furthermore, kinetic analysis of complex formation between the ligands and MR1 suggested that 5‐OP‐RU forms a covalent bond to MR1 in cells within 1 hour. These findings provide guidelines for designing ligands that regulate MAIT cell functions." @default.
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• W3092236675 date "2020-11-16" @default.
• W3092236675 modified "2023-10-13" @default.
• W3092236675 title "The effects of 5‐OP‐RU stereochemistry on its stability and MAIT‐MR1 axis" @default.
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• W3092236675 doi "https://doi.org/10.1002/cbic.202000466" @default.
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