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- W3092241409 abstract "We characterize the breadth, function and phenotype of innate and adaptive cellular responses in a prevention of Mycobacterium tuberculosis infection trial. Responses are measured by whole blood intracellular cytokine staining at baseline and 70 days after vaccination with H4:IC31 (subunit vaccine containing Ag85B and TB10.4), Bacille Calmette-Guerin (BCG, a live attenuated vaccine) or placebo (n = ~30 per group). H4:IC31 vaccination induces Ag85B and TB10.4-specific CD4 T cells, and an unexpected NKTlike subset, that expresses IFN-γ, TNF and/or IL-2. BCG revaccination increases frequencies of CD4 T cell subsets that either express Th1 cytokines or IL-22, and modestly increases IFNγ-producing NK cells. In vitro BCG re-stimulation also triggers responses by donor-unrestricted T cells, which may contribute to host responses against mycobacteria. BCG, which demonstrated efficacy against sustained Mycobacterium tuberculosis infection, modulates multiple immune cell subsets, in particular conventional Th1 and Th22 cells, which should be investigated in discovery studies of correlates of protection." @default.
- W3092241409 created "2020-10-15" @default.
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- W3092241409 date "2020-10-09" @default.
- W3092241409 modified "2023-10-10" @default.
- W3092241409 title "Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines" @default.
- W3092241409 cites W1607536760 @default.
- W3092241409 cites W1630221068 @default.
- W3092241409 cites W1646851899 @default.
- W3092241409 cites W1793351365 @default.
- W3092241409 cites W1965031244 @default.
- W3092241409 cites W1966790981 @default.
- W3092241409 cites W1969503044 @default.
- W3092241409 cites W1971947249 @default.
- W3092241409 cites W1981700081 @default.
- W3092241409 cites W2001743699 @default.
- W3092241409 cites W2009144064 @default.
- W3092241409 cites W2011770661 @default.
- W3092241409 cites W2014578268 @default.
- W3092241409 cites W2015194963 @default.
- W3092241409 cites W2024408211 @default.
- W3092241409 cites W2027160668 @default.
- W3092241409 cites W2035201477 @default.
- W3092241409 cites W2069556438 @default.
- W3092241409 cites W2081130564 @default.
- W3092241409 cites W2084409051 @default.
- W3092241409 cites W2089226849 @default.
- W3092241409 cites W2095664313 @default.
- W3092241409 cites W2107790295 @default.
- W3092241409 cites W2108911207 @default.
- W3092241409 cites W2110807603 @default.
- W3092241409 cites W2111494418 @default.
- W3092241409 cites W2116797415 @default.
- W3092241409 cites W2120799687 @default.
- W3092241409 cites W2132999784 @default.
- W3092241409 cites W2134468562 @default.
- W3092241409 cites W2135437388 @default.
- W3092241409 cites W2137633461 @default.
- W3092241409 cites W2137780892 @default.
- W3092241409 cites W2139710737 @default.
- W3092241409 cites W2143451223 @default.
- W3092241409 cites W2150645172 @default.
- W3092241409 cites W2150785943 @default.
- W3092241409 cites W2152927956 @default.
- W3092241409 cites W2156127164 @default.
- W3092241409 cites W2164309428 @default.
- W3092241409 cites W2166696946 @default.
- W3092241409 cites W2171156871 @default.
- W3092241409 cites W2187945036 @default.
- W3092241409 cites W2276899615 @default.
- W3092241409 cites W2412329023 @default.
- W3092241409 cites W2415369230 @default.
- W3092241409 cites W2497388702 @default.
- W3092241409 cites W2565410267 @default.
- W3092241409 cites W2587862424 @default.
- W3092241409 cites W2592694534 @default.
- W3092241409 cites W2734952601 @default.
- W3092241409 cites W2754288485 @default.
- W3092241409 cites W2792935975 @default.
- W3092241409 cites W2792968344 @default.
- W3092241409 cites W2872754763 @default.
- W3092241409 cites W2883981173 @default.
- W3092241409 cites W2888101674 @default.
- W3092241409 cites W2889537407 @default.
- W3092241409 cites W2893721464 @default.
- W3092241409 cites W2904701318 @default.
- W3092241409 cites W2910312028 @default.
- W3092241409 cites W2920395306 @default.
- W3092241409 cites W2945315710 @default.
- W3092241409 cites W2967169190 @default.
- W3092241409 cites W2967695460 @default.
- W3092241409 cites W2969291753 @default.
- W3092241409 cites W2972255989 @default.
- W3092241409 cites W2981027601 @default.
- W3092241409 cites W2982373118 @default.
- W3092241409 cites W2987234101 @default.
- W3092241409 cites W2989005130 @default.
- W3092241409 cites W2991110224 @default.
- W3092241409 cites W2991344341 @default.
- W3092241409 cites W2997968756 @default.