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- W3092244098 endingPage "118885" @default.
- W3092244098 startingPage "118885" @default.
- W3092244098 abstract "To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization to ensure sufficient supply and to avoid toxic excess of this essential trace element. As pathogens usually encounter iron limitation in the host niche, this metal plays a particular role during virulence. Siderophores are iron-chelators synthesized by most, but not all fungal species to sequester iron extra- and intracellularly. In recent years, the facultative human pathogen Aspergillus fumigatus has become a model for fungal iron homeostasis of siderophore-producing fungal species. This article summarizes the knowledge on fungal iron homeostasis and its links to virulence with a focus on A. fumigatus. It covers mechanisms for iron acquisition, storage, and detoxification, as well as the modes of transcriptional iron regulation and iron sensing in A. fumigatus in comparison to other fungal species. Moreover, potential translational applications of the peculiarities of fungal iron metabolism for treatment and diagnosis of fungal infections is addressed." @default.
- W3092244098 created "2020-10-15" @default.
- W3092244098 creator A5002693297 @default.
- W3092244098 creator A5054532448 @default.
- W3092244098 creator A5060027924 @default.
- W3092244098 creator A5083124187 @default.
- W3092244098 date "2021-01-01" @default.
- W3092244098 modified "2023-10-14" @default.
- W3092244098 title "Fungal iron homeostasis with a focus on Aspergillus fumigatus" @default.
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