Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092245763> ?p ?o ?g. }
- W3092245763 endingPage "105129" @default.
- W3092245763 startingPage "105129" @default.
- W3092245763 abstract "Alzheimer's disease (AD) disproportionately affects certain racial and ethnic subgroups, such as African American/Black and Hispanic adults. Genetic, comorbid, and socioeconomic risk factors contribute to this disparity; however, the molecular contributions have been largely unexplored. Herein, we conducted a pilot proteomics study of postmortem brains from African American/Black and non-Hispanic White adults neuropathologically diagnosed with AD compared to closely-matched cognitively normal individuals. Examination of hippocampus, inferior parietal lobule, and globus pallidus regions using quantitative proteomics resulted in 568 differentially-expressed proteins in AD. These proteins were consistent with the literature and included glial fibrillary acidic protein, peroxiredoxin-1, and annexin A5. In addition, 351 novel proteins in AD were identified, which could partially be due to cohort diversity. From linear regression analyses, we identified 185 proteins with significant race x diagnosis interactions across various brain regions. These differences generally were reflective of differential expression of proteins in AD that occurred in only a single racial/ethnic group. Overall, this pilot study suggests that disease understanding can be furthered by including diversity in racial/ethnic groups; however, this must be done on a larger scale." @default.
- W3092245763 created "2020-10-15" @default.
- W3092245763 creator A5000414426 @default.
- W3092245763 creator A5009545818 @default.
- W3092245763 creator A5009725612 @default.
- W3092245763 creator A5010114260 @default.
- W3092245763 creator A5015953736 @default.
- W3092245763 creator A5044341689 @default.
- W3092245763 date "2020-12-01" @default.
- W3092245763 modified "2023-10-01" @default.
- W3092245763 title "Inclusion of African American/Black adults in a pilot brain proteomics study of Alzheimer's disease" @default.
- W3092245763 cites W15770206 @default.
- W3092245763 cites W1617495083 @default.
- W3092245763 cites W1619053513 @default.
- W3092245763 cites W1687509216 @default.
- W3092245763 cites W1856753584 @default.
- W3092245763 cites W1902208672 @default.
- W3092245763 cites W1970749899 @default.
- W3092245763 cites W1973114730 @default.
- W3092245763 cites W1973725374 @default.
- W3092245763 cites W1986611113 @default.
- W3092245763 cites W1991623690 @default.
- W3092245763 cites W1992017446 @default.
- W3092245763 cites W1995859195 @default.
- W3092245763 cites W2000808937 @default.
- W3092245763 cites W2003958717 @default.
- W3092245763 cites W2012626734 @default.
- W3092245763 cites W2016358822 @default.
- W3092245763 cites W2018477409 @default.
- W3092245763 cites W2026318779 @default.
- W3092245763 cites W2029887257 @default.
- W3092245763 cites W2036394417 @default.
- W3092245763 cites W2039596660 @default.
- W3092245763 cites W2041399392 @default.
- W3092245763 cites W2049262684 @default.
- W3092245763 cites W2052209709 @default.
- W3092245763 cites W2052742260 @default.
- W3092245763 cites W2055467683 @default.
- W3092245763 cites W2056015216 @default.
- W3092245763 cites W2057757222 @default.
- W3092245763 cites W2058622897 @default.
- W3092245763 cites W2058880763 @default.
- W3092245763 cites W2064024026 @default.
- W3092245763 cites W2071817336 @default.
- W3092245763 cites W2072761036 @default.
- W3092245763 cites W2075495871 @default.
- W3092245763 cites W2077303669 @default.
- W3092245763 cites W2083625312 @default.
- W3092245763 cites W2083719092 @default.
- W3092245763 cites W2087305487 @default.
- W3092245763 cites W2087633823 @default.
- W3092245763 cites W2092902275 @default.
- W3092245763 cites W2093650784 @default.
- W3092245763 cites W2096240659 @default.
- W3092245763 cites W2103890427 @default.
- W3092245763 cites W2106814023 @default.
- W3092245763 cites W2114330749 @default.
- W3092245763 cites W2115821900 @default.
- W3092245763 cites W2119341498 @default.
- W3092245763 cites W2126677724 @default.
- W3092245763 cites W2128510822 @default.
- W3092245763 cites W2129357983 @default.
- W3092245763 cites W2132554074 @default.
- W3092245763 cites W2134547791 @default.
- W3092245763 cites W2134724878 @default.
- W3092245763 cites W2135581618 @default.
- W3092245763 cites W2142801465 @default.
- W3092245763 cites W2145796722 @default.
- W3092245763 cites W2149662513 @default.
- W3092245763 cites W2151119363 @default.
- W3092245763 cites W2151966408 @default.
- W3092245763 cites W2162770463 @default.
- W3092245763 cites W2162801491 @default.
- W3092245763 cites W2170819436 @default.
- W3092245763 cites W2194882682 @default.
- W3092245763 cites W2198664180 @default.
- W3092245763 cites W2223389754 @default.
- W3092245763 cites W2238733797 @default.
- W3092245763 cites W2266863819 @default.
- W3092245763 cites W2311668744 @default.
- W3092245763 cites W2339593696 @default.
- W3092245763 cites W2343549769 @default.
- W3092245763 cites W2510361771 @default.
- W3092245763 cites W2563754444 @default.
- W3092245763 cites W2598228247 @default.
- W3092245763 cites W2601488696 @default.
- W3092245763 cites W2605454964 @default.
- W3092245763 cites W2626410531 @default.
- W3092245763 cites W2738398314 @default.
- W3092245763 cites W2763354059 @default.
- W3092245763 cites W2765308988 @default.
- W3092245763 cites W2782564735 @default.
- W3092245763 cites W2791403874 @default.
- W3092245763 cites W2795057010 @default.
- W3092245763 cites W2798267333 @default.
- W3092245763 cites W2891635110 @default.
- W3092245763 cites W2895694428 @default.
- W3092245763 cites W2903592416 @default.