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- W3092248216 abstract "Type-1 lepra reaction commonly occurs in borderline leprosy as a result of cellular immune response to Mycobacterium leprae antigen, and it’s characterized as acute inflammation. Clinical manifestations of type-1 lepra reaction are leprosy lesions with or without ulceration, edema, neuritis, permanent nerve damage and disability. Interleukin-17 (IL-17) and interferon gamma (IFN-γ) tests in leprosy patients can help in anticipating type-1 lepra reaction that commonly causes disability. This case control study was carried out from March to July 2015 in 60 borderline leprosy patients with and without type-1 reaction at Skin and Venereal Unit of Dr. Soetomo Teaching Hospital, Surabaya, Indonesia. We used ELISAto measure IL-17 and IFN-γ levels. We found a significant IL-17 level difference between borderline leprosy patients with and without type-1 reaction (3.7 pg/mL vs. 3 pg/mL; p = 0.005). On the other hand, there was no significant IFN-γ difference between borderline leprosy patients with and without type-1 reaction (53.15 pg/mL vs. 44.15 pg/mL; p = 0.680). IL-17 had a more dominant role in type-1 lepra reaction. There was a significant IL-17 level difference between borderline leprosy patients with and without type-1 reaction." @default.
- W3092248216 created "2020-10-15" @default.
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- W3092248216 date "2020-07-01" @default.
- W3092248216 modified "2023-09-26" @default.
- W3092248216 title "Interleukin-17 and Interferon Gamma Serum Level Differences in Borderline Leprosy Patients" @default.
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- W3092248216 doi "https://doi.org/10.1166/jctn.2020.9143" @default.
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