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• W3092254857 endingPage "111618" @default.
• W3092254857 startingPage "111618" @default.
• W3092254857 abstract "Regarding side effects of commonly used chemotherapeutic drugs on normal tissues, researchers introduced smart delivery and on-demand release systems. Herein, we applied a bivalent aptamer composed of ATP and AS1411 aptamers for separate targeting and gating of mesoporous silica nanoparticles in a ladder like structure with one bifunctional molecule. First part of the apatmer, AS1411, direct the delivery system to the desired site while the second part, ATP aptamer, opens the pores and release the drug just after penetrance to the cytoplasm ensuring delivery of DOX into the tumor cells. This approach faced the previous challenge of coincident targeting and gating with one aptamer. Our results demonstrated that the proposed nano-system remarkably accumulated in cancer tissue and released the drug in a sustained pattern in cancer cells. It was notably effective for inducing apoptosis in cancer cells and tumor growth inhibition without any significant side effect on normal cells and organs. Moreover, Si-cs-DOX-AAapt improved the mice survival time compared with free doxorubicin and there was no significant change in weight of mice administered with the targeted formulation. This report may open new insight for providing smart delivery systems for successful cancer treatment by introducing separate gating and targeting property by a bivalent aptamer to increase the control over drug release. • We applied a bivalent ATP and AS1411 aptamers for targeting and gating of MSNs. • First part of the apatmer, AS1411, direct the delivery system to the desired site • ATP aptamer, opens the pores and release the DOX just after penetrance to the cytoplasm • The system was notably effective for tumor growth inhibition in vivo . • The proposed nano-system remarkably accumulated in tumor tissue" @default.
• W3092254857 created "2020-10-15" @default.
• W3092254857 creator A5015103898 @default.
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• W3092254857 date "2021-02-01" @default.
• W3092254857 modified "2023-09-24" @default.
• W3092254857 title "Ladder-like targeted and gated doxorubicin delivery using bivalent aptamer in vitro and in vivo" @default.
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• W3092254857 doi "https://doi.org/10.1016/j.msec.2020.111618" @default.
• W3092254857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33321660" @default.
• W3092254857 hasPublicationYear "2021" @default.
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