Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092260550> ?p ?o ?g. }
- W3092260550 abstract "Nearly all bacteria are encased in a peptidoglycan cell wall, an essential polysaccharide structure that protects the cell from osmotic rupture and reinforces cell shape. The integrity of this protective barrier must be maintained across the diversity of environmental conditions wherein bacteria replicate. However, at the cell surface, the cell wall and its synthesis machinery face unique challenges that threaten their integrity. Directly exposed to the extracellular environment, the peptidoglycan synthesis machinery encounters dynamic and extreme physicochemical conditions, which may impair enzymatic activity and critical protein-protein interactions. Biotic and abiotic stressors—including host defenses, cell wall active antibiotics, and predatory bacteria and phage—also jeopardize peptidoglycan integrity by introducing lesions, which must be rapidly repaired to prevent cell lysis. Here, we review recently discovered mechanisms that promote robust peptidoglycan synthesis during environmental and acute stress and highlight the opportunities and challenges for the development of cell wall active therapeutics." @default.
- W3092260550 created "2020-10-15" @default.
- W3092260550 creator A5030104916 @default.
- W3092260550 creator A5034275737 @default.
- W3092260550 date "2020-10-27" @default.
- W3092260550 modified "2023-10-16" @default.
- W3092260550 title "Bacterial Cell Wall Quality Control during Environmental Stress" @default.
- W3092260550 cites W1513966234 @default.
- W3092260550 cites W1576771905 @default.
- W3092260550 cites W1578073842 @default.
- W3092260550 cites W1654064765 @default.
- W3092260550 cites W1676178724 @default.
- W3092260550 cites W1877496624 @default.
- W3092260550 cites W1885768087 @default.
- W3092260550 cites W1897608858 @default.
- W3092260550 cites W1919928164 @default.
- W3092260550 cites W1972269365 @default.
- W3092260550 cites W1972624067 @default.
- W3092260550 cites W1975943954 @default.
- W3092260550 cites W1988294842 @default.
- W3092260550 cites W1989423690 @default.
- W3092260550 cites W2009114587 @default.
- W3092260550 cites W2009316827 @default.
- W3092260550 cites W2022725992 @default.
- W3092260550 cites W2023038885 @default.
- W3092260550 cites W2023683042 @default.
- W3092260550 cites W2025789697 @default.
- W3092260550 cites W2028224799 @default.
- W3092260550 cites W2028501115 @default.
- W3092260550 cites W2029207581 @default.
- W3092260550 cites W2034365378 @default.
- W3092260550 cites W2037347466 @default.
- W3092260550 cites W2037846585 @default.
- W3092260550 cites W2039328204 @default.
- W3092260550 cites W2044251513 @default.
- W3092260550 cites W2048593866 @default.
- W3092260550 cites W2053970377 @default.
- W3092260550 cites W2055100675 @default.
- W3092260550 cites W2059114757 @default.
- W3092260550 cites W2061772313 @default.
- W3092260550 cites W2063119446 @default.
- W3092260550 cites W2065689013 @default.
- W3092260550 cites W2069126433 @default.
- W3092260550 cites W2070173384 @default.
- W3092260550 cites W2070190311 @default.
- W3092260550 cites W2071051512 @default.
- W3092260550 cites W2075234068 @default.
- W3092260550 cites W2077096472 @default.
- W3092260550 cites W2085859115 @default.
- W3092260550 cites W2092704978 @default.
- W3092260550 cites W2095480650 @default.
- W3092260550 cites W2095658523 @default.
- W3092260550 cites W2097075466 @default.
- W3092260550 cites W2102911601 @default.
- W3092260550 cites W2104259937 @default.
- W3092260550 cites W2106884274 @default.
- W3092260550 cites W2107777445 @default.
- W3092260550 cites W2108073693 @default.
- W3092260550 cites W2118761676 @default.
- W3092260550 cites W2120662154 @default.
- W3092260550 cites W2121603008 @default.
- W3092260550 cites W2123641688 @default.
- W3092260550 cites W2130730370 @default.
- W3092260550 cites W2132620143 @default.
- W3092260550 cites W2133760875 @default.
- W3092260550 cites W2135102440 @default.
- W3092260550 cites W2135561070 @default.
- W3092260550 cites W2136485465 @default.
- W3092260550 cites W2140396902 @default.
- W3092260550 cites W2142684354 @default.
- W3092260550 cites W2143012569 @default.
- W3092260550 cites W2145490060 @default.
- W3092260550 cites W2147044107 @default.
- W3092260550 cites W2151328375 @default.
- W3092260550 cites W2151395519 @default.
- W3092260550 cites W2153572376 @default.
- W3092260550 cites W2157915163 @default.
- W3092260550 cites W2158336252 @default.
- W3092260550 cites W2158514767 @default.
- W3092260550 cites W2161871973 @default.
- W3092260550 cites W2163029786 @default.
- W3092260550 cites W2167208367 @default.
- W3092260550 cites W2288003344 @default.
- W3092260550 cites W2324515915 @default.
- W3092260550 cites W2335936816 @default.
- W3092260550 cites W2433340252 @default.
- W3092260550 cites W2465253836 @default.
- W3092260550 cites W2507914022 @default.
- W3092260550 cites W2517176893 @default.
- W3092260550 cites W2521365029 @default.
- W3092260550 cites W2539297274 @default.
- W3092260550 cites W2568090253 @default.
- W3092260550 cites W2574611111 @default.
- W3092260550 cites W2588204280 @default.
- W3092260550 cites W2588422564 @default.
- W3092260550 cites W2588858142 @default.
- W3092260550 cites W2606657672 @default.
- W3092260550 cites W2741492879 @default.
- W3092260550 cites W2744027325 @default.
- W3092260550 cites W2769504769 @default.