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- W3092282479 endingPage "100442" @default.
- W3092282479 startingPage "100442" @default.
- W3092282479 abstract "The global pandemic of SARS-CoV-2 has disrupted human social activities. In restarting economic activities, successive outbreaks by new variants are concerning. Here, we evaluated the applicability of public database annotations to estimate the virulence, transmission trends and origins of emerging SARS-CoV-2 variants. Among the detectable multiple mutations, we retraced the mutation in the spike protein. With the aid of the protein database, structural modelling yielded a testable scientific hypothesis on viral entry to host cells. Simultaneously, annotations for locations and collection dates suggested that the variant virus emerged somewhere in the world in approximately February 2020, entered the USA and propagated nationwide with periodic sampling fluctuation likely due to an approximately 5-day incubation delay. Thus, public database annotations are useful for automated elucidation of the early spreading patterns in relation to human behaviours, which should provide objective reference for local governments for social decision making to contain emerging substrains. We propose that additional annotations for past paths and symptoms of the patients should further assist in characterizing the exact virulence and origins of emerging pathogens." @default.
- W3092282479 created "2020-10-15" @default.
- W3092282479 creator A5029914605 @default.
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- W3092282479 creator A5056962155 @default.
- W3092282479 creator A5088306988 @default.
- W3092282479 date "2020-01-01" @default.
- W3092282479 modified "2023-09-27" @default.
- W3092282479 title "Virus database annotations assist in tracing information on patients infected with emerging pathogens" @default.
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- W3092282479 doi "https://doi.org/10.1016/j.imu.2020.100442" @default.
- W3092282479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7543791" @default.
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- W3092282479 hasPublicationYear "2020" @default.
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