Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092291289> ?p ?o ?g. }
- W3092291289 abstract "To ensure their survival, pathogens have to adapt immediately to new environments in their hosts, for example, during the transition from the gut to the bloodstream. Here, we investigated the basis of this adaptation in a group of fungal species which are among the most common causes of hospital-acquired infections, the Candida species. On the basis of a human whole-blood infection model, we studied which genes and processes are active over the course of an infection in both the host and four different Candida pathogens. Remarkably, we found that, while the human host response during the early phase of infection is predominantly uniform, the pathogens pursue largely individual strategies and each one regulates genes involved in largely disparate processes in the blood. Our results reveal that C. albicans , C. glabrata , C. parapsilosis , and C. tropicalis all have developed individual strategies for survival in the host. This indicates that their pathogenicity in humans has evolved several times independently and that genes which are central for survival in the host for one species may be irrelevant in another." @default.
- W3092291289 created "2020-10-15" @default.
- W3092291289 creator A5000809255 @default.
- W3092291289 creator A5011368040 @default.
- W3092291289 creator A5019017859 @default.
- W3092291289 creator A5028255654 @default.
- W3092291289 creator A5044917199 @default.
- W3092291289 creator A5055402965 @default.
- W3092291289 creator A5060264967 @default.
- W3092291289 creator A5060877511 @default.
- W3092291289 creator A5062721343 @default.
- W3092291289 creator A5081266274 @default.
- W3092291289 creator A5087512061 @default.
- W3092291289 creator A5089395284 @default.
- W3092291289 date "2020-10-27" @default.
- W3092291289 modified "2023-09-29" @default.
- W3092291289 title "Survival Strategies of Pathogenic <i>Candida</i> Species in Human Blood Show Independent and Specific Adaptations" @default.
- W3092291289 cites W1502421007 @default.
- W3092291289 cites W1582560245 @default.
- W3092291289 cites W1594375336 @default.
- W3092291289 cites W1647692986 @default.
- W3092291289 cites W1752435689 @default.
- W3092291289 cites W1785625320 @default.
- W3092291289 cites W1817988031 @default.
- W3092291289 cites W1843525095 @default.
- W3092291289 cites W1884430856 @default.
- W3092291289 cites W1969353942 @default.
- W3092291289 cites W1980366975 @default.
- W3092291289 cites W1982281067 @default.
- W3092291289 cites W1986871998 @default.
- W3092291289 cites W1990172999 @default.
- W3092291289 cites W1992030675 @default.
- W3092291289 cites W1992994480 @default.
- W3092291289 cites W2000183570 @default.
- W3092291289 cites W2002221873 @default.
- W3092291289 cites W2002836781 @default.
- W3092291289 cites W2004104098 @default.
- W3092291289 cites W2004992298 @default.
- W3092291289 cites W2005249358 @default.
- W3092291289 cites W2009527638 @default.
- W3092291289 cites W2010270225 @default.
- W3092291289 cites W2012627423 @default.
- W3092291289 cites W2012731024 @default.
- W3092291289 cites W2015593638 @default.
- W3092291289 cites W2020541351 @default.
- W3092291289 cites W2020653359 @default.
- W3092291289 cites W2021442034 @default.
- W3092291289 cites W2023261567 @default.
- W3092291289 cites W2037007916 @default.
- W3092291289 cites W2042655557 @default.
- W3092291289 cites W2051586681 @default.
- W3092291289 cites W2053867514 @default.
- W3092291289 cites W2054164850 @default.
- W3092291289 cites W2057549505 @default.
- W3092291289 cites W2060721894 @default.
- W3092291289 cites W2068373367 @default.
- W3092291289 cites W2078384276 @default.
- W3092291289 cites W2081736048 @default.
- W3092291289 cites W2087971659 @default.
- W3092291289 cites W2088309256 @default.
- W3092291289 cites W2093914439 @default.
- W3092291289 cites W2096766502 @default.
- W3092291289 cites W2097653053 @default.
- W3092291289 cites W2099241550 @default.
- W3092291289 cites W2099881697 @default.
- W3092291289 cites W2100246797 @default.
- W3092291289 cites W2100478563 @default.
- W3092291289 cites W2102387530 @default.
- W3092291289 cites W2102496935 @default.
- W3092291289 cites W2105924489 @default.
- W3092291289 cites W2106248075 @default.
- W3092291289 cites W2106860332 @default.
- W3092291289 cites W2109963121 @default.
- W3092291289 cites W2110874942 @default.
- W3092291289 cites W2112344697 @default.
- W3092291289 cites W2113165438 @default.
- W3092291289 cites W2114950068 @default.
- W3092291289 cites W2117464846 @default.
- W3092291289 cites W2117494447 @default.
- W3092291289 cites W2123439193 @default.
- W3092291289 cites W2124863746 @default.
- W3092291289 cites W2125264518 @default.
- W3092291289 cites W2126848171 @default.
- W3092291289 cites W2127142654 @default.
- W3092291289 cites W2129725063 @default.
- W3092291289 cites W2131271579 @default.
- W3092291289 cites W2134909835 @default.
- W3092291289 cites W2135840745 @default.
- W3092291289 cites W2137959581 @default.
- W3092291289 cites W2138207763 @default.
- W3092291289 cites W2140153053 @default.
- W3092291289 cites W2140729960 @default.
- W3092291289 cites W2141294282 @default.
- W3092291289 cites W2141563676 @default.
- W3092291289 cites W2145564764 @default.
- W3092291289 cites W2148681378 @default.
- W3092291289 cites W2149946566 @default.
- W3092291289 cites W2151635271 @default.
- W3092291289 cites W2152663489 @default.
- W3092291289 cites W2153104382 @default.