FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092301564> ?p ?o ?g. }

• W3092301564 abstract "We measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2 in 343 North American patients infected with SARS-CoV-2 (of which 93% required hospitalization) up to 122 days after symptom onset and compared them to responses in 1548 individuals whose blood samples were obtained prior to the pandemic. After setting seropositivity thresholds for perfect specificity (100%), we estimated sensitivities of 95% for IgG, 90% for IgA, and 81% for IgM for detecting infected individuals between 15 and 28 days after symptom onset. While the median time to seroconversion was nearly 12 days across all three isotypes tested, IgA and IgM antibodies against RBD were short-lived with median times to seroreversion of 71 and 49 days after symptom onset. In contrast, anti-RBD IgG responses decayed slowly through 90 days with only 3 seropositive individuals seroreverting within this time period. IgG antibodies to SARS-CoV-2 RBD were strongly correlated with anti-S neutralizing antibody titers, which demonstrated little to no decrease over 75 days since symptom onset. We observed no cross-reactivity of the SARS-CoV-2 RBD-targeted antibodies with other widely circulating coronaviruses (HKU1, 229 E, OC43, NL63). These data suggest that RBD-targeted antibodies are excellent markers of previous and recent infection, that differential isotype measurements can help distinguish between recent and older infections, and that IgG responses persist over the first few months after infection and are highly correlated with neutralizing antibodies." @default.
• W3092301564 created "2020-10-15" @default.
• W3092301564 creator A5001374764 @default.
• W3092301564 creator A5006406866 @default.
• W3092301564 creator A5009269320 @default.
• W3092301564 creator A5012977198 @default.
• W3092301564 creator A5015246989 @default.
• W3092301564 creator A5016479802 @default.
• W3092301564 creator A5018576534 @default.
• W3092301564 creator A5023826858 @default.
• W3092301564 creator A5034632085 @default.
• W3092301564 creator A5040008768 @default.
• W3092301564 creator A5040112819 @default.
• W3092301564 creator A5041178880 @default.
• W3092301564 creator A5043394077 @default.
• W3092301564 creator A5043835740 @default.
• W3092301564 creator A5044457308 @default.
• W3092301564 creator A5044815567 @default.
• W3092301564 creator A5045788106 @default.
• W3092301564 creator A5046584692 @default.
• W3092301564 creator A5047645117 @default.
• W3092301564 creator A5047999668 @default.
• W3092301564 creator A5048166533 @default.
• W3092301564 creator A5050367455 @default.
• W3092301564 creator A5053002955 @default.
• W3092301564 creator A5054247332 @default.
• W3092301564 creator A5056275493 @default.
• W3092301564 creator A5058367141 @default.
• W3092301564 creator A5059371880 @default.
• W3092301564 creator A5060275984 @default.
• W3092301564 creator A5062681585 @default.
• W3092301564 creator A5069008693 @default.
• W3092301564 creator A5069193792 @default.
• W3092301564 creator A5081650390 @default.
• W3092301564 creator A5084859141 @default.
• W3092301564 creator A5085997642 @default.
• W3092301564 creator A5035250830 @default.
• W3092301564 date "2020-10-08" @default.
• W3092301564 modified "2023-10-14" @default.
• W3092301564 title "Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients" @default.
• W3092301564 cites W2735956566 @default.
• W3092301564 cites W2767648131 @default.
• W3092301564 cites W3007298159 @default.
• W3092301564 cites W3012846954 @default.
• W3092301564 cites W3016586571 @default.
• W3092301564 cites W3017106545 @default.
• W3092301564 cites W3023698680 @default.
• W3092301564 cites W3024178701 @default.
• W3092301564 cites W3024506939 @default.
• W3092301564 cites W3026558549 @default.
• W3092301564 cites W3027204812 @default.
• W3092301564 cites W3033192149 @default.
• W3092301564 cites W3034680516 @default.
• W3092301564 cites W3036931136 @default.
• W3092301564 cites W3041667833 @default.
• W3092301564 cites W3043482067 @default.
• W3092301564 cites W3049192460 @default.
• W3092301564 cites W3080834570 @default.
• W3092301564 cites W3082342835 @default.
• W3092301564 cites W3082768871 @default.
• W3092301564 cites W3087128437 @default.
• W3092301564 cites W4247389509 @default.
• W3092301564 doi "https://doi.org/10.1126/sciimmunol.abe0367" @default.
• W3092301564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7857394" @default.
• W3092301564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33033172" @default.
• W3092301564 hasPublicationYear "2020" @default.
• W3092301564 type Work @default.
• W3092301564 sameAs 3092301564 @default.
• W3092301564 citedByCount "515" @default.
• W3092301564 countsByYear W30923015642020 @default.
• W3092301564 countsByYear W30923015642021 @default.
• W3092301564 countsByYear W30923015642022 @default.
• W3092301564 countsByYear W30923015642023 @default.
• W3092301564 crossrefType "journal-article" @default.
• W3092301564 hasAuthorship W3092301564A5001374764 @default.
• W3092301564 hasAuthorship W3092301564A5006406866 @default.
• W3092301564 hasAuthorship W3092301564A5009269320 @default.
• W3092301564 hasAuthorship W3092301564A5012977198 @default.
• W3092301564 hasAuthorship W3092301564A5015246989 @default.
• W3092301564 hasAuthorship W3092301564A5016479802 @default.
• W3092301564 hasAuthorship W3092301564A5018576534 @default.
• W3092301564 hasAuthorship W3092301564A5023826858 @default.
• W3092301564 hasAuthorship W3092301564A5034632085 @default.
• W3092301564 hasAuthorship W3092301564A5035250830 @default.
• W3092301564 hasAuthorship W3092301564A5040008768 @default.
• W3092301564 hasAuthorship W3092301564A5040112819 @default.
• W3092301564 hasAuthorship W3092301564A5041178880 @default.
• W3092301564 hasAuthorship W3092301564A5043394077 @default.
• W3092301564 hasAuthorship W3092301564A5043835740 @default.
• W3092301564 hasAuthorship W3092301564A5044457308 @default.
• W3092301564 hasAuthorship W3092301564A5044815567 @default.
• W3092301564 hasAuthorship W3092301564A5045788106 @default.
• W3092301564 hasAuthorship W3092301564A5046584692 @default.
• W3092301564 hasAuthorship W3092301564A5047645117 @default.
• W3092301564 hasAuthorship W3092301564A5047999668 @default.
• W3092301564 hasAuthorship W3092301564A5048166533 @default.
• W3092301564 hasAuthorship W3092301564A5050367455 @default.
• W3092301564 hasAuthorship W3092301564A5053002955 @default.
• W3092301564 hasAuthorship W3092301564A5054247332 @default.
• W3092301564 hasAuthorship W3092301564A5056275493 @default.

• next