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- W3092302803 abstract "Previous high-throughput studies in Gram-negative bacteria identified a large number of 3'UTR fragments that potentially function as sRNAs. Here we extensively characterize the MalH sRNA. We show that MalH is a stable degradation intermediate derived from the 3' end of malG, which is part of the maltose uptake operon transcript malEFG. Unlike the majority of bacterial sRNAs, MalH is transiently expressed during the transition from the exponential to the stationary growth phase, suggesting that it contributes to adaptation to changes in nutrient availability. Over-expression of MalH reduces expression of general outer membrane porins and MicA, a repressor of the high-affinity maltose/maltodextrin transporter LamB. Disrupting MalH production and function significantly reduces lamB accumulation when maltose is the only available carbon source, presumably due to the accumulation of the MicA repressor. We propose that MalH is part of a regulatory network that, during the transition phase, directly or indirectly promotes accumulation of high-affinity maltose transporters in the outer membrane by dampening competing pathways." @default.
- W3092302803 created "2020-10-15" @default.
- W3092302803 creator A5002934973 @default.
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- W3092302803 date "2020-10-12" @default.
- W3092302803 modified "2023-10-12" @default.
- W3092302803 title "The mRNA derived MalH sRNA contributes to alternative carbon source utilization by tuning maltoporin expression in E. coli" @default.
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- W3092302803 doi "https://doi.org/10.1080/15476286.2020.1827784" @default.
- W3092302803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8081044" @default.
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