FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092302893> ?p ?o ?g. }

• W3092302893 endingPage "127258" @default.
• W3092302893 startingPage "127258" @default.
• W3092302893 abstract "Nucleic acid, as a design medium, has become one of the most promising biopolymers to perform the dynamic functions, such as catalytic hybridization, target triggered self-assembly and DNA computing in the applications of biosensing, bioimaging and biomedicine. Herein, a DNA addition polymerization (DAP) reaction is proposed to guide the DNA self-assembly towards the construction of size-controlled DNA nanospheres (DNSs). Analogous to chemical step-growth addition polymerization, our proposed DAP reaction is carried out using DNA dimer and DNA hairpin as monomers, in which the initiator acts as both the stimulus and catalyst and N-arm DNA junctions as the structural units, resulting in the formation of three-dimensional DNSs without the generation of by-product. Notably, the designed DAP paradigm is consistent with the molecular logic operation consisted of cascaded AND gates with a feedback mechanism. Further, a versatile nano-drug delivery system is successfully constructed via functionalization the DNSs with chemo-drug (doxorubicin, Dox) and two different siRNAs (anaplastic lymphoma kinase-specific siRNA (ALK-siRNA) and survivin siRNA (Sur-siRNA)) simultaneously. The multifunctional DNSs with good stability and biocompatibility in vitro and in vivo demonstrate an excellent performance in gene-chemo combination therapy of anaplastic large cell lymphoma (ALCL). Overall, the DAP strategy provides a simple yet practical route to build multifunctional DNA nanomaterials, which sheds new light on the development of DNA nanotechnology and cancer therapy." @default.
• W3092302893 created "2020-10-15" @default.
• W3092302893 creator A5009327702 @default.
• W3092302893 creator A5017796397 @default.
• W3092302893 creator A5017943466 @default.
• W3092302893 creator A5038495107 @default.
• W3092302893 creator A5048932334 @default.
• W3092302893 creator A5062750065 @default.
• W3092302893 creator A5063719995 @default.
• W3092302893 creator A5071399285 @default.
• W3092302893 date "2021-03-01" @default.
• W3092302893 modified "2023-10-03" @default.
• W3092302893 title "DNA addition polymerization with logic operation for controllable self-assembly of three-dimensional nanovehicles and combinatorial cancer therapy" @default.
• W3092302893 cites W1849669601 @default.
• W3092302893 cites W1964449356 @default.
• W3092302893 cites W1965897682 @default.
• W3092302893 cites W1973528774 @default.
• W3092302893 cites W1979277560 @default.
• W3092302893 cites W2005615084 @default.
• W3092302893 cites W2042386826 @default.
• W3092302893 cites W2067437988 @default.
• W3092302893 cites W2092528383 @default.
• W3092302893 cites W2096096240 @default.
• W3092302893 cites W2102699655 @default.
• W3092302893 cites W2145303234 @default.
• W3092302893 cites W2145708480 @default.
• W3092302893 cites W2169120163 @default.
• W3092302893 cites W2169302611 @default.
• W3092302893 cites W2169834917 @default.
• W3092302893 cites W2337828948 @default.
• W3092302893 cites W2435664453 @default.
• W3092302893 cites W2528752965 @default.
• W3092302893 cites W2575767844 @default.
• W3092302893 cites W2621228038 @default.
• W3092302893 cites W2733296761 @default.
• W3092302893 cites W2745726206 @default.
• W3092302893 cites W2771784843 @default.
• W3092302893 cites W2774123716 @default.
• W3092302893 cites W2774257054 @default.
• W3092302893 cites W2788055013 @default.
• W3092302893 cites W2790708193 @default.
• W3092302893 cites W2794333370 @default.
• W3092302893 cites W2804598975 @default.
• W3092302893 cites W2884341682 @default.
• W3092302893 cites W2895057567 @default.
• W3092302893 cites W2902691768 @default.
• W3092302893 cites W2911711466 @default.
• W3092302893 cites W2915027573 @default.
• W3092302893 cites W2918782245 @default.
• W3092302893 cites W2928277794 @default.
• W3092302893 cites W2941291293 @default.
• W3092302893 cites W2952028091 @default.
• W3092302893 cites W2967956164 @default.
• W3092302893 cites W2972967487 @default.
• W3092302893 cites W2981379493 @default.
• W3092302893 cites W2990595786 @default.
• W3092302893 cites W2992598102 @default.
• W3092302893 cites W2997276809 @default.
• W3092302893 cites W3023288964 @default.
• W3092302893 doi "https://doi.org/10.1016/j.cej.2020.127258" @default.
• W3092302893 hasPublicationYear "2021" @default.
• W3092302893 type Work @default.
• W3092302893 sameAs 3092302893 @default.
• W3092302893 citedByCount "13" @default.
• W3092302893 countsByYear W30923028932021 @default.
• W3092302893 countsByYear W30923028932022 @default.
• W3092302893 countsByYear W30923028932023 @default.
• W3092302893 crossrefType "journal-article" @default.
• W3092302893 hasAuthorship W3092302893A5009327702 @default.
• W3092302893 hasAuthorship W3092302893A5017796397 @default.
• W3092302893 hasAuthorship W3092302893A5017943466 @default.
• W3092302893 hasAuthorship W3092302893A5038495107 @default.
• W3092302893 hasAuthorship W3092302893A5048932334 @default.
• W3092302893 hasAuthorship W3092302893A5062750065 @default.
• W3092302893 hasAuthorship W3092302893A5063719995 @default.
• W3092302893 hasAuthorship W3092302893A5071399285 @default.
• W3092302893 hasConcept C128972844 @default.
• W3092302893 hasConcept C129275984 @default.
• W3092302893 hasConcept C138631740 @default.
• W3092302893 hasConcept C153911025 @default.
• W3092302893 hasConcept C171250308 @default.
• W3092302893 hasConcept C178790620 @default.
• W3092302893 hasConcept C185592680 @default.
• W3092302893 hasConcept C192562407 @default.
• W3092302893 hasConcept C21951064 @default.
• W3092302893 hasConcept C44228677 @default.
• W3092302893 hasConcept C521977710 @default.
• W3092302893 hasConcept C552990157 @default.
• W3092302893 hasConcept C55493867 @default.
• W3092302893 hasConcept C86803240 @default.
• W3092302893 hasConceptScore W3092302893C128972844 @default.
• W3092302893 hasConceptScore W3092302893C129275984 @default.
• W3092302893 hasConceptScore W3092302893C138631740 @default.
• W3092302893 hasConceptScore W3092302893C153911025 @default.
• W3092302893 hasConceptScore W3092302893C171250308 @default.
• W3092302893 hasConceptScore W3092302893C178790620 @default.
• W3092302893 hasConceptScore W3092302893C185592680 @default.
• W3092302893 hasConceptScore W3092302893C192562407 @default.

• next