FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092315619> ?p ?o ?g. }

• W3092315619 abstract "Natural selection acting on synonymous mutations in protein-coding genes influences genome composition and evolution. In viruses, introducing synonymous mutations in genes encoding structural proteins can drastically reduce viral growth, providing a means to generate potent, live-attenuated vaccine candidates. However, an improved understanding of what compositional features are under selection and how combinations of synonymous mutations affect viral growth is needed to predictably attenuate viruses and make them resistant to reversion. We systematically recoded all nonoverlapping genes of the bacteriophage ΦX174 with codons rarely used in its Escherichia coli host. The fitness of recombinant viruses decreases as additional deoptimizing mutations are made to the genome, although not always linearly, and not consistently across genes. Combining deoptimizing mutations may reduce viral fitness more or less than expected from the effect size of the constituent mutations and we point out difficulties in untangling correlated compositional features. We test our model by optimizing the same genes and find that the relationship between codon usage and fitness does not hold for optimization, suggesting that wild-type ΦX174 is at a fitness optimum. This work highlights the need to better understand how selection acts on patterns of synonymous codon usage across the genome and provides a convenient system to investigate the genetic determinants of virulence." @default.
• W3092315619 created "2020-10-15" @default.
• W3092315619 creator A5014658449 @default.
• W3092315619 creator A5015588274 @default.
• W3092315619 creator A5016737202 @default.
• W3092315619 creator A5022039008 @default.
• W3092315619 creator A5038531193 @default.
• W3092315619 creator A5054775452 @default.
• W3092315619 creator A5076550740 @default.
• W3092315619 creator A5080996898 @default.
• W3092315619 creator A5089627980 @default.
• W3092315619 date "2020-10-12" @default.
• W3092315619 modified "2023-10-03" @default.
• W3092315619 title "ΦX174 Attenuation by Whole-Genome Codon Deoptimization" @default.
• W3092315619 cites W1565578508 @default.
• W3092315619 cites W1777817130 @default.
• W3092315619 cites W1842051142 @default.
• W3092315619 cites W1956613997 @default.
• W3092315619 cites W1964529071 @default.
• W3092315619 cites W1969541700 @default.
• W3092315619 cites W1971529589 @default.
• W3092315619 cites W1971901785 @default.
• W3092315619 cites W1975782217 @default.
• W3092315619 cites W1982054904 @default.
• W3092315619 cites W1983438661 @default.
• W3092315619 cites W1983611592 @default.
• W3092315619 cites W1993358499 @default.
• W3092315619 cites W1993518869 @default.
• W3092315619 cites W1993985216 @default.
• W3092315619 cites W1996153210 @default.
• W3092315619 cites W2000920812 @default.
• W3092315619 cites W2001369581 @default.
• W3092315619 cites W2001674944 @default.
• W3092315619 cites W2004146038 @default.
• W3092315619 cites W2005112911 @default.
• W3092315619 cites W2009818318 @default.
• W3092315619 cites W2011245640 @default.
• W3092315619 cites W2013321787 @default.
• W3092315619 cites W2018097321 @default.
• W3092315619 cites W2018590530 @default.
• W3092315619 cites W2019196452 @default.
• W3092315619 cites W2020302409 @default.
• W3092315619 cites W2022853651 @default.
• W3092315619 cites W2024014229 @default.
• W3092315619 cites W2025569664 @default.
• W3092315619 cites W2027210355 @default.
• W3092315619 cites W2032360710 @default.
• W3092315619 cites W2035475950 @default.
• W3092315619 cites W2037878200 @default.
• W3092315619 cites W2039227019 @default.
• W3092315619 cites W2043170430 @default.
• W3092315619 cites W2046484293 @default.
• W3092315619 cites W2047762623 @default.
• W3092315619 cites W2049867592 @default.
• W3092315619 cites W2051156811 @default.
• W3092315619 cites W2051242197 @default.
• W3092315619 cites W2057088297 @default.
• W3092315619 cites W2059714916 @default.
• W3092315619 cites W2060418270 @default.
• W3092315619 cites W2063504601 @default.
• W3092315619 cites W2066829062 @default.
• W3092315619 cites W2068307739 @default.
• W3092315619 cites W2071667529 @default.
• W3092315619 cites W2071932815 @default.
• W3092315619 cites W2072284352 @default.
• W3092315619 cites W2073881372 @default.
• W3092315619 cites W2076219800 @default.
• W3092315619 cites W2079136072 @default.
• W3092315619 cites W2083842949 @default.
• W3092315619 cites W2085522899 @default.
• W3092315619 cites W2091678991 @default.
• W3092315619 cites W2092035637 @default.
• W3092315619 cites W2094186221 @default.
• W3092315619 cites W2094952096 @default.
• W3092315619 cites W2096406964 @default.
• W3092315619 cites W2099467100 @default.
• W3092315619 cites W2100364553 @default.
• W3092315619 cites W2106067581 @default.
• W3092315619 cites W2107226814 @default.
• W3092315619 cites W2107804881 @default.
• W3092315619 cites W2108670087 @default.
• W3092315619 cites W2120253101 @default.
• W3092315619 cites W2121646171 @default.
• W3092315619 cites W2122834872 @default.
• W3092315619 cites W2125076649 @default.
• W3092315619 cites W2127080018 @default.
• W3092315619 cites W2127338491 @default.
• W3092315619 cites W2140870757 @default.
• W3092315619 cites W2140928112 @default.
• W3092315619 cites W2142997034 @default.
• W3092315619 cites W2145843180 @default.
• W3092315619 cites W2146837785 @default.
• W3092315619 cites W2147839609 @default.
• W3092315619 cites W2148627082 @default.
• W3092315619 cites W2148734328 @default.
• W3092315619 cites W2149172763 @default.
• W3092315619 cites W2151373788 @default.
• W3092315619 cites W2152777703 @default.
• W3092315619 cites W2153120390 @default.
• W3092315619 cites W2155131453 @default.

• next