FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092357235> ?p ?o ?g. }

• W3092357235 abstract "Abstract Colon adenocarcinoma (COAD) is the most common type of gastrointestinal cancer and is still the third leading cause of cancer-related mortality worldwide. Therefore, finding new and promising drugs to eradicate cancer may be a feasible method to treat COAD patients. Cys2-His2 zinc finger proteins (ZFPs) is one of the largest transcription factor family and many of them are highly involved in regulation of cell differentiation, proliferation, apoptosis, and neoplastic transformation. In this study, we identified a tumor-inhibiting factor, ZNF549, which expressed lowly in COAD tissues and COAD cell lines (HT29, HCT116, SW480, LoVo, and SW620). Overexpression of ZNF549 inhibit the ability of COAD cell proliferation and migration. On the contrary, decreasing the ZNF549 expression level promote the ability of COAD cell proliferation and migration. Through bioinformatics analysis, we found that ZNF549 was a potential target of hsa-miR-708-5p (miR-708-5p). Furthermore, we verified the possibility of miR-708-5p targeting the ZNF549 gene, and miR-708-5p inhibited the expression of ZNF549 by luciferase reporter assays, qRT-PCR and western blot assays. Moreover, the relationship between miR-708-5p and phosphatidylinositol 3-kinase/AKt (PI3K/AKt) signal pathway was elucidated. Overexpression and inhibition of miR-708-5p resulted in increased and decreased expression of p-AKt and p-PI3K in HCT116 cells, respectively. RT-qPCR and western blot assays results demonstrated that miR-708-5p regulated COAD cells development by promoting the process of Epithelial-mesenchymal transition (EMT) through PI3K/AKt signaling pathway. In summary, our findings demonstrated that ZNF549, the target gene of miR-708-5p, functions as a tumor suppressor to inhibit COAD cell lines proliferation and migration through regulate the PI3K/AKt signal pathway." @default.
• W3092357235 created "2020-10-15" @default.
• W3092357235 creator A5051689588 @default.
• W3092357235 creator A5081357594 @default.
• W3092357235 date "2020-10-07" @default.
• W3092357235 modified "2023-10-01" @default.
• W3092357235 title "MicroRNA-708 targeting ZNF549 regulates colon adenocarcinoma development through PI3K/AKt pathway" @default.
• W3092357235 cites W1209648782 @default.
• W3092357235 cites W128602447 @default.
• W3092357235 cites W1830858249 @default.
• W3092357235 cites W1844690031 @default.
• W3092357235 cites W1908973472 @default.
• W3092357235 cites W1972863280 @default.
• W3092357235 cites W1979076378 @default.
• W3092357235 cites W1985305471 @default.
• W3092357235 cites W2016360721 @default.
• W3092357235 cites W2027737980 @default.
• W3092357235 cites W2028512550 @default.
• W3092357235 cites W2029799334 @default.
• W3092357235 cites W2044215253 @default.
• W3092357235 cites W2055163056 @default.
• W3092357235 cites W2055435663 @default.
• W3092357235 cites W2082177123 @default.
• W3092357235 cites W2095232311 @default.
• W3092357235 cites W2102717011 @default.
• W3092357235 cites W2107277218 @default.
• W3092357235 cites W2112680319 @default.
• W3092357235 cites W2113266887 @default.
• W3092357235 cites W2130028615 @default.
• W3092357235 cites W2137456063 @default.
• W3092357235 cites W2138975873 @default.
• W3092357235 cites W2170685293 @default.
• W3092357235 cites W2215660606 @default.
• W3092357235 cites W2266517050 @default.
• W3092357235 cites W2315178103 @default.
• W3092357235 cites W2317582029 @default.
• W3092357235 cites W2498795244 @default.
• W3092357235 cites W2748837640 @default.
• W3092357235 cites W2755875138 @default.
• W3092357235 cites W2774316539 @default.
• W3092357235 cites W2774408146 @default.
• W3092357235 cites W2789942970 @default.
• W3092357235 cites W2906602472 @default.
• W3092357235 cites W2911188335 @default.
• W3092357235 cites W4235509360 @default.
• W3092357235 doi "https://doi.org/10.1038/s41598-020-73929-w" @default.
• W3092357235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7541523" @default.
• W3092357235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33028966" @default.
• W3092357235 hasPublicationYear "2020" @default.
• W3092357235 type Work @default.
• W3092357235 sameAs 3092357235 @default.
• W3092357235 citedByCount "13" @default.
• W3092357235 countsByYear W30923572352022 @default.
• W3092357235 countsByYear W30923572352023 @default.
• W3092357235 crossrefType "journal-article" @default.
• W3092357235 hasAuthorship W3092357235A5051689588 @default.
• W3092357235 hasAuthorship W3092357235A5081357594 @default.
• W3092357235 hasBestOaLocation W30923572351 @default.
• W3092357235 hasConcept C104317684 @default.
• W3092357235 hasConcept C145059251 @default.
• W3092357235 hasConcept C190283241 @default.
• W3092357235 hasConcept C2776415932 @default.
• W3092357235 hasConcept C502942594 @default.
• W3092357235 hasConcept C54355233 @default.
• W3092357235 hasConcept C62112901 @default.
• W3092357235 hasConcept C62478195 @default.
• W3092357235 hasConcept C75217442 @default.
• W3092357235 hasConcept C86554907 @default.
• W3092357235 hasConcept C86803240 @default.
• W3092357235 hasConcept C95444343 @default.
• W3092357235 hasConceptScore W3092357235C104317684 @default.
• W3092357235 hasConceptScore W3092357235C145059251 @default.
• W3092357235 hasConceptScore W3092357235C190283241 @default.
• W3092357235 hasConceptScore W3092357235C2776415932 @default.
• W3092357235 hasConceptScore W3092357235C502942594 @default.
• W3092357235 hasConceptScore W3092357235C54355233 @default.
• W3092357235 hasConceptScore W3092357235C62112901 @default.
• W3092357235 hasConceptScore W3092357235C62478195 @default.
• W3092357235 hasConceptScore W3092357235C75217442 @default.
• W3092357235 hasConceptScore W3092357235C86554907 @default.
• W3092357235 hasConceptScore W3092357235C86803240 @default.
• W3092357235 hasConceptScore W3092357235C95444343 @default.
• W3092357235 hasIssue "1" @default.
• W3092357235 hasLocation W30923572351 @default.
• W3092357235 hasLocation W30923572352 @default.
• W3092357235 hasOpenAccess W3092357235 @default.
• W3092357235 hasPrimaryLocation W30923572351 @default.
• W3092357235 hasRelatedWork W2362061149 @default.
• W3092357235 hasRelatedWork W2386182263 @default.
• W3092357235 hasRelatedWork W2438578109 @default.
• W3092357235 hasRelatedWork W2756666042 @default.
• W3092357235 hasRelatedWork W2801038214 @default.
• W3092357235 hasRelatedWork W2948341381 @default.
• W3092357235 hasRelatedWork W3003597902 @default.
• W3092357235 hasRelatedWork W3086670389 @default.
• W3092357235 hasRelatedWork W3139272788 @default.
• W3092357235 hasRelatedWork W4282559781 @default.
• W3092357235 hasVolume "10" @default.
• W3092357235 isParatext "false" @default.
• W3092357235 isRetracted "false" @default.

• next