FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092372015> ?p ?o ?g. }

• W3092372015 endingPage "7666" @default.
• W3092372015 startingPage "7651" @default.
• W3092372015 abstract "Plants have always been a significant source of natural active components with biological properties. Celery seed oil (extracted from Apium graveolens) has several potential applications, but its therapeutic uses in the form of nanoemulsion formulation need to be investigated further in order to meet the demand in cancer treatment, and to alleviate the prevailing crisis arising from increased antimicrobial resistance.The therapeutic potential of celery seed oil was investigated through the formulation and testing of a nanoemulsion developed with Tween 80 (a non-ionic surfactant) and the utilization of an ultrasonication technique. Anticancer and apoptotic properties of the formulation were evaluated through MTT and Annexin V-FITC assays. The clonogenic assay aided in the identification of the antiproliferative properties of the formulation on oral squamous cell carcinoma. The antimicrobial study was supported by agar well diffusion assay, membrane integrity test and scanning electron microscopy.Experiments identified relevant parameters, including optimal surfactant concentration and emulsification time. GC-MS analysis identified various components in the celery oil, but not their biological activities. A sonication time of 20 min resulted in a droplet diameter of 23.4 ± 1.80 nm. The IC50 concentration of the optimal nanoemulsion formulation against SAS cells was 1.4 µL/mL. At this concentration, cell proliferation was significantly reduced through inhibition of the anchorage-independent cell growth by disrupting colony formation and inducing cell death (apoptosis) of cancer cells. The nanoemulsion was also treated with a microbial suspension of S. aureus, and displayed antibacterial properties through lipid membrane fusion, causing cytoplasmic leakage as verified through agar well diffusion and membrane permeability assays. Scanning electron microscopy revealed complete distortion of the bacterial pathogen.The results in this study present celery as a possible constituent for cancer therapeutics and as a candidate for aggressive, yet safe cancer treatment. The celery-based nanoemulsion has the potential to act as a key alternative to standard antibiotic therapy." @default.
• W3092372015 created "2020-10-15" @default.
• W3092372015 creator A5001351247 @default.
• W3092372015 creator A5028220923 @default.
• W3092372015 creator A5040352947 @default.
• W3092372015 creator A5088790066 @default.
• W3092372015 date "2020-10-01" @default.
• W3092372015 modified "2023-10-06" @default.
• W3092372015 title "<p>Preparation of Celery Essential Oil-Based Nanoemulsion by Ultrasonication and Evaluation of Its Potential Anticancer and Antibacterial Activity</p>" @default.
• W3092372015 cites W136104837 @default.
• W3092372015 cites W1498663909 @default.
• W3092372015 cites W1664502515 @default.
• W3092372015 cites W1867339397 @default.
• W3092372015 cites W1938411025 @default.
• W3092372015 cites W1960683232 @default.
• W3092372015 cites W1973847876 @default.
• W3092372015 cites W1993864351 @default.
• W3092372015 cites W2002853272 @default.
• W3092372015 cites W2007124962 @default.
• W3092372015 cites W2008757142 @default.
• W3092372015 cites W2012390919 @default.
• W3092372015 cites W2014011160 @default.
• W3092372015 cites W2017138846 @default.
• W3092372015 cites W2017352677 @default.
• W3092372015 cites W2018605297 @default.
• W3092372015 cites W2020087055 @default.
• W3092372015 cites W2023684070 @default.
• W3092372015 cites W2025357868 @default.
• W3092372015 cites W2027824285 @default.
• W3092372015 cites W2028422139 @default.
• W3092372015 cites W2030414984 @default.
• W3092372015 cites W2037689374 @default.
• W3092372015 cites W2041261502 @default.
• W3092372015 cites W2045373124 @default.
• W3092372015 cites W2048933340 @default.
• W3092372015 cites W2059738518 @default.
• W3092372015 cites W2071901400 @default.
• W3092372015 cites W2072372149 @default.
• W3092372015 cites W2079384315 @default.
• W3092372015 cites W2086976827 @default.
• W3092372015 cites W2097882907 @default.
• W3092372015 cites W2101807596 @default.
• W3092372015 cites W2103517584 @default.
• W3092372015 cites W2104882286 @default.
• W3092372015 cites W2112487247 @default.
• W3092372015 cites W2121628360 @default.
• W3092372015 cites W2121915037 @default.
• W3092372015 cites W2124483381 @default.
• W3092372015 cites W2126817169 @default.
• W3092372015 cites W2126964578 @default.
• W3092372015 cites W2131457953 @default.
• W3092372015 cites W2132834292 @default.
• W3092372015 cites W2133252611 @default.
• W3092372015 cites W2139690794 @default.
• W3092372015 cites W2142140480 @default.
• W3092372015 cites W2148264571 @default.
• W3092372015 cites W2148283430 @default.
• W3092372015 cites W2151080741 @default.
• W3092372015 cites W2153022134 @default.
• W3092372015 cites W2156581772 @default.
• W3092372015 cites W2163032004 @default.
• W3092372015 cites W2170123966 @default.
• W3092372015 cites W2180752973 @default.
• W3092372015 cites W2185564569 @default.
• W3092372015 cites W2341769195 @default.
• W3092372015 cites W2406546035 @default.
• W3092372015 cites W2560919346 @default.
• W3092372015 cites W2608179648 @default.
• W3092372015 cites W2615859300 @default.
• W3092372015 cites W2737466710 @default.
• W3092372015 cites W2771348893 @default.
• W3092372015 cites W2790112413 @default.
• W3092372015 cites W2791781902 @default.
• W3092372015 cites W2793619686 @default.
• W3092372015 cites W2879366474 @default.
• W3092372015 cites W2904437244 @default.
• W3092372015 cites W2911188335 @default.
• W3092372015 cites W2936203807 @default.
• W3092372015 cites W2945482009 @default.
• W3092372015 cites W2960561537 @default.
• W3092372015 cites W2984900914 @default.
• W3092372015 cites W3011381567 @default.
• W3092372015 cites W3018336393 @default.
• W3092372015 cites W4243514341 @default.
• W3092372015 cites W4252438186 @default.
• W3092372015 cites W4362228171 @default.
• W3092372015 cites W4376542800 @default.
• W3092372015 cites W2320550398 @default.
• W3092372015 doi "https://doi.org/10.2147/ijn.s252640" @default.
• W3092372015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7553139" @default.
• W3092372015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33116493" @default.
• W3092372015 hasPublicationYear "2020" @default.
• W3092372015 type Work @default.
• W3092372015 sameAs 3092372015 @default.
• W3092372015 citedByCount "31" @default.
• W3092372015 countsByYear W30923720152021 @default.
• W3092372015 countsByYear W30923720152022 @default.
• W3092372015 countsByYear W30923720152023 @default.

• next