FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092393670> ?p ?o ?g. }

• W3092393670 endingPage "110128" @default.
• W3092393670 startingPage "110128" @default.
• W3092393670 abstract "Cannabis is the illicit drug most widely used by pregnant women worldwide. Its growing acceptance and legalization have markedly increased the risks of child psychopathology, including psychotic-like experiences, which lowers the age of onset for a first psychotic episode. As the majority of patients with schizophrenia go through a premorbid condition long before this occurs, understanding neurobiological underpinnings of the prodromal stage of the disease is critical to improving illness trajectories and therapeutic outcomes. We have previously shown that male rat offspring prenatally exposed to Δ9-tetrahydrocannabinol (THC), a rat model of prenatal cannabinoid exposure (PCE), exhibit extensive molecular and synaptic changes in dopaminergic neurons of the ventral tegmental area (VTA), converging on a hyperdopaminergic state. This leads to a silent psychotic-like endophenotype that is unmasked by a single exposure to THC. Here, we further characterized the VTA dopamine neuron and sensorimotor gating functions of PCE rats exposed to acute stress or a challenge of the D2 receptor agonist apomorphine, by using in vivo single-unit extracellular recordings and Prepulse Inhibition (PPI) analyses. At pre-puberty, PCE male rat offspring display a reduced population activity of VTA dopamine neurons in vivo, the majority of which are tonically active. PCE male progeny also exhibit enhanced sensitivity to dopamine D2 (DAD2) receptor activation and a vulnerability to acute stress, which is associated with compromised sensorimotor gating functions. This data extends our knowledge of the multifaceted sequelae imposed by PCE in the mesolimbic dopamine system of male pre-adolescent rats, which renders a neural substrate highly susceptible to subsequent challenges that may trigger psychotic-like outcomes." @default.
• W3092393670 created "2020-10-15" @default.
• W3092393670 creator A5007511127 @default.
• W3092393670 creator A5031087600 @default.
• W3092393670 creator A5032465522 @default.
• W3092393670 creator A5045189209 @default.
• W3092393670 creator A5056130178 @default.
• W3092393670 creator A5065978965 @default.
• W3092393670 creator A5085620061 @default.
• W3092393670 date "2021-03-01" @default.
• W3092393670 modified "2023-10-10" @default.
• W3092393670 title "Mesolimbic dopamine dysregulation as a signature of information processing deficits imposed by prenatal THC exposure" @default.
• W3092393670 cites W1518761532 @default.
• W3092393670 cites W1633847368 @default.
• W3092393670 cites W1895741221 @default.
• W3092393670 cites W1934223132 @default.
• W3092393670 cites W1941293036 @default.
• W3092393670 cites W1949404224 @default.
• W3092393670 cites W1966052367 @default.
• W3092393670 cites W1966343623 @default.
• W3092393670 cites W1966715692 @default.
• W3092393670 cites W1967579836 @default.
• W3092393670 cites W1967675418 @default.
• W3092393670 cites W1980967004 @default.
• W3092393670 cites W1994978840 @default.
• W3092393670 cites W1994984635 @default.
• W3092393670 cites W1999328412 @default.
• W3092393670 cites W2001468486 @default.
• W3092393670 cites W2003584239 @default.
• W3092393670 cites W2004686541 @default.
• W3092393670 cites W2004927151 @default.
• W3092393670 cites W2006548599 @default.
• W3092393670 cites W2018436006 @default.
• W3092393670 cites W2023455876 @default.
• W3092393670 cites W2026617358 @default.
• W3092393670 cites W2030496268 @default.
• W3092393670 cites W2043354652 @default.
• W3092393670 cites W2047016005 @default.
• W3092393670 cites W2049244494 @default.
• W3092393670 cites W2061954127 @default.
• W3092393670 cites W2071227017 @default.
• W3092393670 cites W2071239491 @default.
• W3092393670 cites W2072175866 @default.
• W3092393670 cites W2073320418 @default.
• W3092393670 cites W2073929631 @default.
• W3092393670 cites W2074818354 @default.
• W3092393670 cites W2076457657 @default.
• W3092393670 cites W2079353098 @default.
• W3092393670 cites W2084283970 @default.
• W3092393670 cites W2086779090 @default.
• W3092393670 cites W2094247576 @default.
• W3092393670 cites W2095914266 @default.
• W3092393670 cites W2095937566 @default.
• W3092393670 cites W2098582456 @default.
• W3092393670 cites W2100040139 @default.
• W3092393670 cites W2113742168 @default.
• W3092393670 cites W2120310131 @default.
• W3092393670 cites W2140986639 @default.
• W3092393670 cites W2148655327 @default.
• W3092393670 cites W2152591277 @default.
• W3092393670 cites W2154145851 @default.
• W3092393670 cites W2155900685 @default.
• W3092393670 cites W2160695817 @default.
• W3092393670 cites W2167125619 @default.
• W3092393670 cites W2171592792 @default.
• W3092393670 cites W2174471971 @default.
• W3092393670 cites W2229859804 @default.
• W3092393670 cites W2314444949 @default.
• W3092393670 cites W2411013142 @default.
• W3092393670 cites W2486451269 @default.
• W3092393670 cites W2510367665 @default.
• W3092393670 cites W2519531315 @default.
• W3092393670 cites W2561063118 @default.
• W3092393670 cites W2562069737 @default.
• W3092393670 cites W2574957280 @default.
• W3092393670 cites W2596798372 @default.
• W3092393670 cites W2614025280 @default.
• W3092393670 cites W2750152983 @default.
• W3092393670 cites W2799776129 @default.
• W3092393670 cites W2822896643 @default.
• W3092393670 cites W2884388515 @default.
• W3092393670 cites W2890758070 @default.
• W3092393670 cites W2900025101 @default.
• W3092393670 cites W2949898193 @default.
• W3092393670 cites W2974190183 @default.
• W3092393670 cites W2977295290 @default.
• W3092393670 cites W2979667926 @default.
• W3092393670 cites W2979752717 @default.
• W3092393670 cites W2981190174 @default.
• W3092393670 cites W2981585873 @default.
• W3092393670 cites W3013568653 @default.
• W3092393670 cites W3020636843 @default.
• W3092393670 cites W4211025465 @default.
• W3092393670 cites W4211060198 @default.
• W3092393670 cites W4239716400 @default.
• W3092393670 cites W4296219707 @default.
• W3092393670 cites W4366658024 @default.
• W3092393670 cites W860960216 @default.

• next