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- W3092399443 abstract "Achromobacter spp. are becoming increasingly associated with lung infections in patients suffering from cystic fibrosis (CF). A. marplatensis, which is closely related to A. xylosoxidans, has been isolated from the lungs of CF patients and other human infections. This article describes the isolation, morphology and characterization of two lytic bacteriophages specific for an A. marplatensis strain isolated from a pneumonia patient. This host strain was the causal agent of hospital acquired pneumonia–the first clinical report of such an occurrence. Full genome sequencing revealed bacteriophage genomes ranging in size from 45901 to 46,328 bp. Transmission electron microscopy revealed that the two bacteriophages AMA1 and AMA2 belonged to the Siphoviridae family. Host range analysis showed that their host range did not extend to A. xylosoxidans. The possibility exists for future testing of such bacteriophages in the control of Achromobacter infections such as those seen in CF and other infections of the lungs. The incidence of antibiotic resistance in this genus highlights the importance of seeking adjuncts and alternatives in CF and other lung infections." @default.
- W3092399443 created "2020-10-15" @default.
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- W3092399443 date "2020-10-08" @default.
- W3092399443 modified "2023-09-29" @default.
- W3092399443 title "Characterization of Novel Lytic Bacteriophages of Achromobacter marplantensis Isolated from a Pneumonia Patient" @default.
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- W3092399443 doi "https://doi.org/10.3390/v12101138" @default.
- W3092399443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7600146" @default.
- W3092399443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33049935" @default.
- W3092399443 hasPublicationYear "2020" @default.
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