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- W3092400814 abstract "Purpose In the present study, we investigated the potential of QSM to assess the physiological state of cortical tissue in the middle cerebral artery occlusion canine model of a cerebral ischemia. Methods Experiments were performed in 8 anesthetized canines. Gradient echo, perfusion, and DWI data of brains at normal and ischemic states were acquired. In the postprocessed susceptibility and quantitative cerebral blood flow maps, changes in values within the middle cerebral artery‐fed cortical territories were quantified both on the ischemic and normal contralateral hemisphere side. Results QSM values in critically ischemic tissue were significantly different from contralateral values—namely, susceptibility increase was observed in the cases in which cerebral perfusion was maintained above the threshold of neuronal death. Furthermore, the data indicates presence of a significant correlation between the changes in susceptibility values, cerebral perfusion, and the infarct volume and pial collateral scores. Additionally, our data suggests that difference in cortical susceptibility is prospectively indicative of the infarct growth rate. Conclusion In an experimental permanent middle cerebral artery occlusion model, QSM was shown to correlate with the functional parameters characterizing viability of ischemic tissue, thus warranting further research on its ability to provide complementary information during acute stroke MRI examinations in humans." @default.
- W3092400814 created "2020-10-15" @default.
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- W3092400814 date "2020-10-09" @default.
- W3092400814 modified "2023-09-26" @default.
- W3092400814 title "QSM in canine model of acute cerebral ischemia: A pilot study" @default.
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- W3092400814 doi "https://doi.org/10.1002/mrm.28498" @default.
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