FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092401693> ?p ?o ?g. }

• W3092401693 endingPage "102458" @default.
• W3092401693 startingPage "102458" @default.
• W3092401693 abstract "DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder, as compared with controls. Since MDD is highly correlated with anxiety, we hypothesized that symptoms of anxiety, as well as lower volume of grey matter (GM) in depression-related cortical regions, will be associated with faster epigenetic clock in a community-based sample of young adults. Participants included 88 young adults (53% men; 23–24 years of age) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) who participated in its neuroimaging follow-up and provided saliva samples for epigenetic analysis. Epigenetic age was calculated according to Horvath (Horvath, 2013). Women had slower epigenetic clock than men (Cohen’s d = 0.48). In women (but not men), slower epigenetic clock was associated with less symptoms of anxiety. In the brain, women (but not men) with slower epigenetic clock had greater GM volume in the cerebral cortex (brain size-corrected; R2 = 0.07). Lobe-specific analyses showed that in women (but not men), slower epigenetic clock was associated with greater GM volume in frontal lobe (R2 = 0.16), and that GM volume in frontal lobe mediated the relationship between the speed of epigenetic clock and anxiety trait (ab = 0.15, SE = 0.15, 95% CI [0.007; 0.369]). These findings were not replicated, however, in a community-based sample of adolescents (n = 129; 49% men; 12–19 years of age), possibly due to the different method of tissue collection (blood vs. saliva) or additional sources of variability in the cohort of adolescents (puberty stages, socioeconomic status, prenatal exposure to maternal smoking during pregnancy)." @default.
• W3092401693 created "2020-10-15" @default.
• W3092401693 creator A5008874281 @default.
• W3092401693 creator A5023243017 @default.
• W3092401693 creator A5027349128 @default.
• W3092401693 creator A5036364963 @default.
• W3092401693 creator A5041024457 @default.
• W3092401693 creator A5044391883 @default.
• W3092401693 creator A5059670464 @default.
• W3092401693 creator A5060054317 @default.
• W3092401693 creator A5090081842 @default.
• W3092401693 date "2020-01-01" @default.
• W3092401693 modified "2023-10-17" @default.
• W3092401693 title "Epigenetic clock as a correlate of anxiety" @default.
• W3092401693 cites W1527571618 @default.
• W3092401693 cites W1613418177 @default.
• W3092401693 cites W1755973449 @default.
• W3092401693 cites W1957468587 @default.
• W3092401693 cites W1963163807 @default.
• W3092401693 cites W1972219651 @default.
• W3092401693 cites W1974047233 @default.
• W3092401693 cites W1994823296 @default.
• W3092401693 cites W1996474046 @default.
• W3092401693 cites W2005468223 @default.
• W3092401693 cites W2015317023 @default.
• W3092401693 cites W2037689983 @default.
• W3092401693 cites W2044569637 @default.
• W3092401693 cites W2057428050 @default.
• W3092401693 cites W2079246150 @default.
• W3092401693 cites W2080098346 @default.
• W3092401693 cites W2092857010 @default.
• W3092401693 cites W2094643645 @default.
• W3092401693 cites W2097345383 @default.
• W3092401693 cites W2110004174 @default.
• W3092401693 cites W2118826874 @default.
• W3092401693 cites W2121091193 @default.
• W3092401693 cites W2126769529 @default.
• W3092401693 cites W2127431419 @default.
• W3092401693 cites W2138108661 @default.
• W3092401693 cites W2145151017 @default.
• W3092401693 cites W2152292563 @default.
• W3092401693 cites W2158554646 @default.
• W3092401693 cites W2162500823 @default.
• W3092401693 cites W2164797478 @default.
• W3092401693 cites W2166322905 @default.
• W3092401693 cites W2169556367 @default.
• W3092401693 cites W2188949284 @default.
• W3092401693 cites W2196351065 @default.
• W3092401693 cites W2346576232 @default.
• W3092401693 cites W2491158000 @default.
• W3092401693 cites W2505539351 @default.
• W3092401693 cites W2561168632 @default.
• W3092401693 cites W2612475180 @default.
• W3092401693 cites W2745417329 @default.
• W3092401693 cites W2747576011 @default.
• W3092401693 cites W2752781686 @default.
• W3092401693 cites W2774553566 @default.
• W3092401693 cites W2787791202 @default.
• W3092401693 cites W2794179132 @default.
• W3092401693 cites W2800301228 @default.
• W3092401693 cites W2883344038 @default.
• W3092401693 cites W2884961706 @default.
• W3092401693 cites W2890102264 @default.
• W3092401693 cites W3124097319 @default.
• W3092401693 cites W4297888942 @default.
• W3092401693 doi "https://doi.org/10.1016/j.nicl.2020.102458" @default.
• W3092401693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7585143" @default.
• W3092401693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33395955" @default.
• W3092401693 hasPublicationYear "2020" @default.
• W3092401693 type Work @default.
• W3092401693 sameAs 3092401693 @default.
• W3092401693 citedByCount "10" @default.
• W3092401693 countsByYear W30924016932021 @default.
• W3092401693 countsByYear W30924016932022 @default.
• W3092401693 countsByYear W30924016932023 @default.
• W3092401693 crossrefType "journal-article" @default.
• W3092401693 hasAuthorship W3092401693A5008874281 @default.
• W3092401693 hasAuthorship W3092401693A5023243017 @default.
• W3092401693 hasAuthorship W3092401693A5027349128 @default.
• W3092401693 hasAuthorship W3092401693A5036364963 @default.
• W3092401693 hasAuthorship W3092401693A5041024457 @default.
• W3092401693 hasAuthorship W3092401693A5044391883 @default.
• W3092401693 hasAuthorship W3092401693A5059670464 @default.
• W3092401693 hasAuthorship W3092401693A5060054317 @default.
• W3092401693 hasAuthorship W3092401693A5090081842 @default.
• W3092401693 hasBestOaLocation W30924016931 @default.
• W3092401693 hasConcept C104317684 @default.
• W3092401693 hasConcept C118552586 @default.
• W3092401693 hasConcept C150194340 @default.
• W3092401693 hasConcept C15744967 @default.
• W3092401693 hasConcept C190727270 @default.
• W3092401693 hasConcept C41091548 @default.
• W3092401693 hasConcept C54355233 @default.
• W3092401693 hasConcept C558461103 @default.
• W3092401693 hasConcept C58693492 @default.
• W3092401693 hasConcept C70410870 @default.
• W3092401693 hasConcept C71924100 @default.
• W3092401693 hasConcept C86803240 @default.

• next