FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092421016> ?p ?o ?g. }

• W3092421016 endingPage "5865" @default.
• W3092421016 startingPage "5844" @default.
• W3092421016 abstract "Immune-related genes play a significant role in predicting the overall survival and monitoring the status of the cancer immune microenvironment. The aim of this research study was to identify differentially expressed immune-related genes (DEIRGs) and establish a Cox prediction model for the evaluation of prognosis in patients with non-small cell lung cancer (NSCLC). Transcription expression data, immune gene data, and tumor transcription factor data from The Cancer Genome Atlas (TCGA), the Immunology Database and Analysis Portal, and the Cistrome Cancer database were analyzed to detect differentially expressed genes (DEGs), DEIRGs, and differentially expressed transcription factors (DETFs). Multivariate Cox regression analysis was used to obtain potential DEIRGs as independent prognostic factors. Oncomine, The Human Protein Atlas (HPA), TIMER databases were performed to validate the mRNA and protein expression level of DEIRGs. TIMER database was performed to explore the immunocytes infiltration of DEIRGs. In total, 7448 DEGs, 536 DEIRGs, 87 DETFs were identified from 1,037 NSCLC tissues and 108 normal tissues in TCGA database. Fifteen-DEIRG signatures (THBS1, S100P, S100A16, DLL4, CD70, DKK1, IL33, NRTN, PDGFB, STC2, VGF, GCGR, HTR3A, LGR4, SHC3) could be perceived as independent prognostic factors for predicting the overall survival of patients with NSCLC (P = 4.89e--09). Immune cell correlation analysis showed that neutrophils and b cells were positively and negatively correlated with the riskscore of the prediction model, respectively. Our study identified a Cox prediction model based on DEIRGs to predict the overall survival of patients with NSCLC. The immunocyte infiltration analysis provided a novel horizon for monitoring the status of the NSCLC immune microenvironment." @default.
• W3092421016 created "2020-10-15" @default.
• W3092421016 creator A5010702785 @default.
• W3092421016 creator A5011645302 @default.
• W3092421016 creator A5020251798 @default.
• W3092421016 creator A5032767831 @default.
• W3092421016 creator A5056310516 @default.
• W3092421016 creator A5075287925 @default.
• W3092421016 creator A5081675173 @default.
• W3092421016 date "2020-01-01" @default.
• W3092421016 modified "2023-09-23" @default.
• W3092421016 title "Identification and validation of the prognostic value of immune-related genes in non-small cell lung cancer." @default.
• W3092421016 cites W1977466146 @default.
• W3092421016 cites W2004913788 @default.
• W3092421016 cites W2025738474 @default.
• W3092421016 cites W2029852405 @default.
• W3092421016 cites W2035618305 @default.
• W3092421016 cites W2082668371 @default.
• W3092421016 cites W2088720324 @default.
• W3092421016 cites W2096086497 @default.
• W3092421016 cites W2122683221 @default.
• W3092421016 cites W2125508691 @default.
• W3092421016 cites W2130685100 @default.
• W3092421016 cites W2152429112 @default.
• W3092421016 cites W2272984102 @default.
• W3092421016 cites W2551911481 @default.
• W3092421016 cites W2599766640 @default.
• W3092421016 cites W2765224588 @default.
• W3092421016 cites W2765240211 @default.
• W3092421016 cites W2765480297 @default.
• W3092421016 cites W2772146395 @default.
• W3092421016 cites W2790227650 @default.
• W3092421016 cites W2800502807 @default.
• W3092421016 cites W2809431387 @default.
• W3092421016 cites W2889254874 @default.
• W3092421016 cites W2908785659 @default.
• W3092421016 cites W2909008483 @default.
• W3092421016 cites W2910111050 @default.
• W3092421016 cites W2911335821 @default.
• W3092421016 cites W2917837889 @default.
• W3092421016 cites W2920152277 @default.
• W3092421016 cites W2926636056 @default.
• W3092421016 cites W2930553605 @default.
• W3092421016 cites W2931790623 @default.
• W3092421016 cites W2944258161 @default.
• W3092421016 cites W2950603908 @default.
• W3092421016 cites W2970597159 @default.
• W3092421016 cites W2975213011 @default.
• W3092421016 cites W2976515477 @default.
• W3092421016 cites W2978614136 @default.
• W3092421016 cites W2981555900 @default.
• W3092421016 cites W2985798777 @default.
• W3092421016 cites W2992897657 @default.
• W3092421016 cites W2996012059 @default.
• W3092421016 cites W2998939694 @default.
• W3092421016 cites W3007551489 @default.
• W3092421016 cites W3014352410 @default.
• W3092421016 cites W991683603 @default.
• W3092421016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7540139" @default.
• W3092421016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33042464" @default.
• W3092421016 hasPublicationYear "2020" @default.
• W3092421016 type Work @default.
• W3092421016 sameAs 3092421016 @default.
• W3092421016 citedByCount "15" @default.
• W3092421016 countsByYear W30924210162021 @default.
• W3092421016 countsByYear W30924210162022 @default.
• W3092421016 countsByYear W30924210162023 @default.
• W3092421016 crossrefType "journal-article" @default.
• W3092421016 hasAuthorship W3092421016A5010702785 @default.
• W3092421016 hasAuthorship W3092421016A5011645302 @default.
• W3092421016 hasAuthorship W3092421016A5020251798 @default.
• W3092421016 hasAuthorship W3092421016A5032767831 @default.
• W3092421016 hasAuthorship W3092421016A5056310516 @default.
• W3092421016 hasAuthorship W3092421016A5075287925 @default.
• W3092421016 hasAuthorship W3092421016A5081675173 @default.
• W3092421016 hasConcept C104317684 @default.
• W3092421016 hasConcept C126322002 @default.
• W3092421016 hasConcept C143998085 @default.
• W3092421016 hasConcept C203014093 @default.
• W3092421016 hasConcept C2776256026 @default.
• W3092421016 hasConcept C502942594 @default.
• W3092421016 hasConcept C50382708 @default.
• W3092421016 hasConcept C54355233 @default.
• W3092421016 hasConcept C71924100 @default.
• W3092421016 hasConcept C86339819 @default.
• W3092421016 hasConcept C86803240 @default.
• W3092421016 hasConcept C8891405 @default.
• W3092421016 hasConceptScore W3092421016C104317684 @default.
• W3092421016 hasConceptScore W3092421016C126322002 @default.
• W3092421016 hasConceptScore W3092421016C143998085 @default.
• W3092421016 hasConceptScore W3092421016C203014093 @default.
• W3092421016 hasConceptScore W3092421016C2776256026 @default.
• W3092421016 hasConceptScore W3092421016C502942594 @default.
• W3092421016 hasConceptScore W3092421016C50382708 @default.
• W3092421016 hasConceptScore W3092421016C54355233 @default.
• W3092421016 hasConceptScore W3092421016C71924100 @default.
• W3092421016 hasConceptScore W3092421016C86339819 @default.
• W3092421016 hasConceptScore W3092421016C86803240 @default.

• next