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- W3092446162 endingPage "2270" @default.
- W3092446162 startingPage "2270" @default.
- W3092446162 abstract "Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a transition from rather homogeneous epithelial-like pluripotent stem cell colonies into a three-dimensional organization of various cell types with multifaceted cell–cell interactions and lumen formation—a process associated with repetitive epithelial-mesenchymal transitions. In the last few years, culture methods have further evolved to better control EB size, growth, cellular composition, and organization—e.g., by the addition of morphogens or different extracellular matrix molecules. There is a growing perception that the mechanical properties, cell mechanics, and cell signaling during EB development are also influenced by physical cues to better guide lineage specification; substrate elasticity and topography are relevant, as well as shear stress and mechanical strain. Epithelial structures outside and inside EBs support the integrity of the cell aggregates and counteract mechanical stress. Furthermore, hydrogels can be used to better control the organization and lineage-specific differentiation of EBs. In this review, we summarize how EB formation is accompanied by a variety of biomechanical parameters that need to be considered for the directed and reproducible self-organization of early cell fate decisions." @default.
- W3092446162 created "2020-10-15" @default.
- W3092446162 creator A5026397452 @default.
- W3092446162 creator A5049119120 @default.
- W3092446162 creator A5064261992 @default.
- W3092446162 creator A5083253707 @default.
- W3092446162 date "2020-10-11" @default.
- W3092446162 modified "2023-10-16" @default.
- W3092446162 title "Cell Mechanics in Embryoid Bodies" @default.
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